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Analysis of Salmonella enterica serotype-host specificity in calves: avirulence of S. enterica serotype gallinarum correlates with bacterial dissemination from mesenteric lymph nodes and persistence in vivo.
Infect Immun. 2002 Dec; 70(12):6788-97.II

Abstract

Host and bacterial factors that determine whether Salmonella serotypes remain restricted to the gastrointestinal tract or penetrate beyond the mucosa and cause systemic disease remain largely undefined. Here, factors influencing Salmonella host specificity in calves were assessed by characterizing the pathogenesis of different serotypes. Salmonella enterica serotype Dublin was highly virulent intravenously, whereas S. enterica serotype Choleraesuis was moderately virulent. Both serotypes were virulent in calves infected orally. In contrast, S. enterica serotypes Gallinarum and Abortusovis were avirulent by either route. Serotypes Dublin, Gallinarum, and Abortusovis colonized the intestinal tract 24 h after oral inoculation, yet only serotype Dublin was consistently recovered from systemic tissues. Serotypes Dublin and Gallinarum invaded bovine intestines in greater numbers and induced greater enteropathogenic responses than serotypes Choleraesuis and Abortusovis. However, only serotype Dublin was able to persist within the intestinal mucosa, and use of a novel cannulation model demonstrated that serotype Dublin was able to pass through the mesenteric lymph nodes in greater numbers than serotype Gallinarum. Together, these results suggest that initial interactions with the intestinal mucosa do not correlate with host specificity, although persistence within tissues and translocation via efferent lymphatics appear to be crucial for the induction of bovine salmonellosis.

Authors+Show Affiliations

Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12438354

Citation

Paulin, Susan M., et al. "Analysis of Salmonella Enterica Serotype-host Specificity in Calves: Avirulence of S. Enterica Serotype Gallinarum Correlates With Bacterial Dissemination From Mesenteric Lymph Nodes and Persistence in Vivo." Infection and Immunity, vol. 70, no. 12, 2002, pp. 6788-97.
Paulin SM, Watson PR, Benmore AR, et al. Analysis of Salmonella enterica serotype-host specificity in calves: avirulence of S. enterica serotype gallinarum correlates with bacterial dissemination from mesenteric lymph nodes and persistence in vivo. Infect Immun. 2002;70(12):6788-97.
Paulin, S. M., Watson, P. R., Benmore, A. R., Stevens, M. P., Jones, P. W., Villarreal-Ramos, B., & Wallis, T. S. (2002). Analysis of Salmonella enterica serotype-host specificity in calves: avirulence of S. enterica serotype gallinarum correlates with bacterial dissemination from mesenteric lymph nodes and persistence in vivo. Infection and Immunity, 70(12), 6788-97.
Paulin SM, et al. Analysis of Salmonella Enterica Serotype-host Specificity in Calves: Avirulence of S. Enterica Serotype Gallinarum Correlates With Bacterial Dissemination From Mesenteric Lymph Nodes and Persistence in Vivo. Infect Immun. 2002;70(12):6788-97. PubMed PMID: 12438354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of Salmonella enterica serotype-host specificity in calves: avirulence of S. enterica serotype gallinarum correlates with bacterial dissemination from mesenteric lymph nodes and persistence in vivo. AU - Paulin,Susan M, AU - Watson,Patricia R, AU - Benmore,Annette R, AU - Stevens,Mark P, AU - Jones,Philip W, AU - Villarreal-Ramos,Bernardo, AU - Wallis,Timothy S, PY - 2002/11/20/pubmed PY - 2003/1/8/medline PY - 2002/11/20/entrez SP - 6788 EP - 97 JF - Infection and immunity JO - Infect Immun VL - 70 IS - 12 N2 - Host and bacterial factors that determine whether Salmonella serotypes remain restricted to the gastrointestinal tract or penetrate beyond the mucosa and cause systemic disease remain largely undefined. Here, factors influencing Salmonella host specificity in calves were assessed by characterizing the pathogenesis of different serotypes. Salmonella enterica serotype Dublin was highly virulent intravenously, whereas S. enterica serotype Choleraesuis was moderately virulent. Both serotypes were virulent in calves infected orally. In contrast, S. enterica serotypes Gallinarum and Abortusovis were avirulent by either route. Serotypes Dublin, Gallinarum, and Abortusovis colonized the intestinal tract 24 h after oral inoculation, yet only serotype Dublin was consistently recovered from systemic tissues. Serotypes Dublin and Gallinarum invaded bovine intestines in greater numbers and induced greater enteropathogenic responses than serotypes Choleraesuis and Abortusovis. However, only serotype Dublin was able to persist within the intestinal mucosa, and use of a novel cannulation model demonstrated that serotype Dublin was able to pass through the mesenteric lymph nodes in greater numbers than serotype Gallinarum. Together, these results suggest that initial interactions with the intestinal mucosa do not correlate with host specificity, although persistence within tissues and translocation via efferent lymphatics appear to be crucial for the induction of bovine salmonellosis. SN - 0019-9567 UR - https://www.unboundmedicine.com/medline/citation/12438354/Analysis_of_Salmonella_enterica_serotype_host_specificity_in_calves:_avirulence_of_S__enterica_serotype_gallinarum_correlates_with_bacterial_dissemination_from_mesenteric_lymph_nodes_and_persistence_in_vivo_ L2 - https://journals.asm.org/doi/10.1128/IAI.70.12.6788-6797.2002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -