Tags

Type your tag names separated by a space and hit enter

Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease.

Abstract

Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58,515 women with invasive breast cancer and 95,067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19-1.45, P<0.00001) for an intake of 35-44 g per day alcohol, and 1.46 (1.33-1.61, P<0.00001) for >/=45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P<0.00001) for each additional 10 g per day intake of alcohol, i.e. for each extra unit or drink of alcohol consumed on a daily basis. This increase was the same in ever-smokers and never-smokers (7.1% per 10 g per day, P<0.00001, in each group). By contrast, the relationship between smoking and breast cancer was substantially confounded by the effect of alcohol. When analyses were restricted to 22 255 women with breast cancer and 40 832 controls who reported drinking no alcohol, smoking was not associated with breast cancer (compared to never-smokers, relative risk for ever-smokers=1.03, 95% CI 0.98-1.07, and for current smokers=0.99, 0.92-1.05). The results for alcohol and for tobacco did not vary substantially across studies, study designs, or according to 15 personal characteristics of the women; nor were the findings materially confounded by any of these factors. If the observed relationship for alcohol is causal, these results suggest that about 4% of the breast cancers in developed countries are attributable to alcohol. In developing countries, where alcohol consumption among controls averaged only 0.4 g per day, alcohol would have a negligible effect on the incidence of breast cancer. In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis and cancers of the mouth, larynx, oesophagus and liver.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Cancer Research UK Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK.

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    British journal of cancer 87:11 2002 Nov 18 pg 1234-45

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Breast Neoplasms
    Cardiovascular Diseases
    Developing Countries
    Epidemiologic Studies
    Female
    Humans
    Incidence
    Middle Aged
    Risk Assessment
    Smoking

    Pub Type(s)

    Comment
    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12439712

    Citation

    Hamajima, N, et al. "Alcohol, Tobacco and Breast Cancer--collaborative Reanalysis of Individual Data From 53 Epidemiological Studies, Including 58,515 Women With Breast Cancer and 95,067 Women Without the Disease." British Journal of Cancer, vol. 87, no. 11, 2002, pp. 1234-45.
    Hamajima N, Hirose K, Tajima K, et al. Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer. 2002;87(11):1234-45.
    Hamajima, N., Hirose, K., Tajima, K., Rohan, T., Calle, E. E., Heath, C. W., ... Meirik, O. (2002). Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. British Journal of Cancer, 87(11), pp. 1234-45.
    Hamajima N, et al. Alcohol, Tobacco and Breast Cancer--collaborative Reanalysis of Individual Data From 53 Epidemiological Studies, Including 58,515 Women With Breast Cancer and 95,067 Women Without the Disease. Br J Cancer. 2002 Nov 18;87(11):1234-45. PubMed PMID: 12439712.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. AU - Hamajima,N, AU - Hirose,K, AU - Tajima,K, AU - Rohan,T, AU - Calle,E E, AU - Heath,C W,Jr AU - Coates,R J, AU - Liff,J M, AU - Talamini,R, AU - Chantarakul,N, AU - Koetsawang,S, AU - Rachawat,D, AU - Morabia,A, AU - Schuman,L, AU - Stewart,W, AU - Szklo,M, AU - Bain,C, AU - Schofield,F, AU - Siskind,V, AU - Band,P, AU - Coldman,A J, AU - Gallagher,R P, AU - Hislop,T G, AU - Yang,P, AU - Kolonel,L M, AU - Nomura,A M Y, AU - Hu,J, AU - Johnson,K C, AU - Mao,Y, AU - De Sanjosé,S, AU - Lee,N, AU - Marchbanks,P, AU - Ory,H W, AU - Peterson,H B, AU - Wilson,H G, AU - Wingo,P A, AU - Ebeling,K, AU - Kunde,D, AU - Nishan,P, AU - Hopper,J L, AU - Colditz,G, AU - Gajalanski,V, AU - Martin,N, AU - Pardthaisong,T, AU - Silpisornkosol,S, AU - Theetranont,C, AU - Boosiri,B, AU - Chutivongse,S, AU - Jimakorn,P, AU - Virutamasen,P, AU - Wongsrichanalai,C, AU - Ewertz,M, AU - Adami,H O, AU - Bergkvist,L, AU - Magnusson,C, AU - Persson,I, AU - Chang-Claude,J, AU - Paul,C, AU - Skegg,D C G, AU - Spears,G F S, AU - Boyle,P, AU - Evstifeeva,T, AU - Daling,J R, AU - Hutchinson,W B, AU - Malone,K, AU - Noonan,E A, AU - Stanford,J L, AU - Thomas,D B, AU - Weiss,N S, AU - White,E, AU - Andrieu,N, AU - Brêmond,A, AU - Clavel,F, AU - Gairard,B, AU - Lansac,J, AU - Piana,L, AU - Renaud,R, AU - Izquierdo,A, AU - Viladiu,P, AU - Cuevas,H R, AU - Ontiveros,P, AU - Palet,A, AU - Salazar,S B, AU - Aristizabel,N, AU - Cuadros,A, AU - Tryggvadottir,L, AU - Tulinius,H, AU - Bachelot,A, AU - Lê,M G, AU - Peto,J, AU - Franceschi,S, AU - Lubin,F, AU - Modan,B, AU - Ron,E, AU - Wax,Y, AU - Friedman,G D, AU - Hiatt,R A, AU - Levi,F, AU - Bishop,T, AU - Kosmelj,K, AU - Primic-Zakelj,M, AU - Ravnihar,B, AU - Stare,J, AU - Beeson,W L, AU - Fraser,G, AU - Bullbrook,R D, AU - Cuzick,J, AU - Duffy,S W, AU - Fentiman,I S, AU - Hayward,J L, AU - Wang,D Y, AU - McMichael,A J, AU - McPherson,K, AU - Hanson,R L, AU - Leske,M C, AU - Mahoney,M C, AU - Nasca,P C, AU - Varma,A O, AU - Weinstein,A L, AU - Moller,T R, AU - Olsson,H, AU - Ranstam,J, AU - Goldbohm,R A, AU - van den Brandt,P A, AU - Apelo,R A, AU - Baens,J, AU - de la Cruz,J R, AU - Javier,B, AU - Lacaya,L B, AU - Ngelangel,C A, AU - La Vecchia,C, AU - Negri,E, AU - Marubini,E, AU - Ferraroni,M, AU - Gerber,M, AU - Richardson,S, AU - Segala,C, AU - Gatei,D, AU - Kenya,P, AU - Kungu,A, AU - Mati,J G, AU - Brinton,L A, AU - Hoover,R, AU - Schairer,C, AU - Spirtas,R, AU - Lee,H P, AU - Rookus,M A, AU - van Leeuwen,F E, AU - Schoenberg,J A, AU - McCredie,M, AU - Gammon,M D, AU - Clarke,E A, AU - Jones,L, AU - Neil,A, AU - Vessey,M, AU - Yeates,D, AU - Appleby,P, AU - Banks,E, AU - Beral,V, AU - Bull,D, AU - Crossley,B, AU - Goodill,A, AU - Green,J, AU - Hermon,C, AU - Key,T, AU - Langston,N, AU - Lewis,C, AU - Reeves,G, AU - Collins,R, AU - Doll,R, AU - Peto,R, AU - Mabuchi,K, AU - Preston,D, AU - Hannaford,P, AU - Kay,C, AU - Rosero-Bixby,L, AU - Gao,Y T, AU - Jin,F, AU - Yuan,J-M, AU - Wei,H Y, AU - Yun,T, AU - Zhiheng,C, AU - Berry,G, AU - Cooper Booth,J, AU - Jelihovsky,T, AU - MacLennan,R, AU - Shearman,R, AU - Wang,Q-S, AU - Baines,C-J, AU - Miller,A B, AU - Wall,C, AU - Lund,E, AU - Stalsberg,H, AU - Shu,X O, AU - Zheng,W, AU - Katsouyanni,K, AU - Trichopoulou,A, AU - Trichopoulos,D, AU - Dabancens,A, AU - Martinez,L, AU - Molina,R, AU - Salas,O, AU - Alexander,F E, AU - Anderson,K, AU - Folsom,A R, AU - Hulka,B S, AU - Bernstein,L, AU - Enger,S, AU - Haile,R W, AU - Paganini-Hill,A, AU - Pike,M C, AU - Ross,R K, AU - Ursin,G, AU - Yu,M C, AU - Longnecker,M P, AU - Newcomb,P, AU - Bergkvist,L, AU - Kalache,A, AU - Farley,T M M, AU - Holck,S, AU - Meirik,O, AU - ,, PY - 2002/06/12/received PY - 2002/08/08/revised PY - 2002/08/23/accepted PY - 2002/11/20/pubmed PY - 2003/1/9/medline PY - 2002/11/20/entrez SP - 1234 EP - 45 JF - British journal of cancer JO - Br. J. Cancer VL - 87 IS - 11 N2 - Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58,515 women with invasive breast cancer and 95,067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19-1.45, P<0.00001) for an intake of 35-44 g per day alcohol, and 1.46 (1.33-1.61, P<0.00001) for >/=45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P<0.00001) for each additional 10 g per day intake of alcohol, i.e. for each extra unit or drink of alcohol consumed on a daily basis. This increase was the same in ever-smokers and never-smokers (7.1% per 10 g per day, P<0.00001, in each group). By contrast, the relationship between smoking and breast cancer was substantially confounded by the effect of alcohol. When analyses were restricted to 22 255 women with breast cancer and 40 832 controls who reported drinking no alcohol, smoking was not associated with breast cancer (compared to never-smokers, relative risk for ever-smokers=1.03, 95% CI 0.98-1.07, and for current smokers=0.99, 0.92-1.05). The results for alcohol and for tobacco did not vary substantially across studies, study designs, or according to 15 personal characteristics of the women; nor were the findings materially confounded by any of these factors. If the observed relationship for alcohol is causal, these results suggest that about 4% of the breast cancers in developed countries are attributable to alcohol. In developing countries, where alcohol consumption among controls averaged only 0.4 g per day, alcohol would have a negligible effect on the incidence of breast cancer. In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis and cancers of the mouth, larynx, oesophagus and liver. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/12439712/Alcohol_tobacco_and_breast_cancer__collaborative_reanalysis_of_individual_data_from_53_epidemiological_studies_including_58515_women_with_breast_cancer_and_95067_women_without_the_disease_ L2 - http://dx.doi.org/10.1038/sj.bjc.6600596 DB - PRIME DP - Unbound Medicine ER -