Tags

Type your tag names separated by a space and hit enter

Crotalidae polyvalent immune Fab (ovine) antivenom is efficacious for envenomations by Southern Pacific rattlesnakes (Crotalus helleri).
Ann Emerg Med. 2002 Dec; 40(6):619-24.AE

Abstract

STUDY OBJECTIVE

Southern Pacific rattlesnake (Crotalus helleri) venom is not 1 of the 4 venoms used to produce Crotalidae polyvalent immune Fab (ovine) (CroFab; FabAV). There is currently no published clinical experience regarding the efficacy of this new antivenom for confirmed C helleri envenomation, and animal data suggest greatly diminished efficacy. We assessed the efficacy of FabAV for patients with confirmed C helleri envenomation.

METHODS

We conducted a prospective observational study of 23 consecutive rattlesnake envenomations that were treated with FabAV at our center. Patients were excluded if the species of snake could not be confirmed, if FabAV antivenom was not given, or if Antivenin (Crotalidae) polyvalent (equine) was given. We collected serial physical examination and laboratory data over a 24-hour period to serially evaluate the severity score and performed follow-up to evaluate delayed reactions.

RESULTS

There were 15 patients who received FabAV and had the species of rattlesnake confirmed (9 C helleri, 4 C scutulatus scutulatus, 1 C mitchellii pyrrhus, 1 C ruber ruber). C helleri envenomations demonstrated similar improvement in serial snakebite severity scores to those of other species. Three patients treated with scheduled dosing had recurrence of progressive swelling (2 C helleri and 1 C mitchellii pyrrhus) during the 24-hour study period.

CONCLUSION

We observed similar improvement in FabAV-treated patients with C helleri envenomation compared with those of other species and conclude that this treatment in standard doses appears efficacious for bites by this species. Progressive swelling may recur despite scheduled dosing.

Authors+Show Affiliations

Department of Emergency Medicine, Loma Linda University School of Medicine, Medical Center and Children's Hospital, Loma Linda, CA, USA. famensean@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12447339

Citation

Bush, Sean P., et al. "Crotalidae Polyvalent Immune Fab (ovine) Antivenom Is Efficacious for Envenomations By Southern Pacific Rattlesnakes (Crotalus Helleri)." Annals of Emergency Medicine, vol. 40, no. 6, 2002, pp. 619-24.
Bush SP, Green SM, Moynihan JA, et al. Crotalidae polyvalent immune Fab (ovine) antivenom is efficacious for envenomations by Southern Pacific rattlesnakes (Crotalus helleri). Ann Emerg Med. 2002;40(6):619-24.
Bush, S. P., Green, S. M., Moynihan, J. A., Hayes, W. K., & Cardwell, M. D. (2002). Crotalidae polyvalent immune Fab (ovine) antivenom is efficacious for envenomations by Southern Pacific rattlesnakes (Crotalus helleri). Annals of Emergency Medicine, 40(6), 619-24.
Bush SP, et al. Crotalidae Polyvalent Immune Fab (ovine) Antivenom Is Efficacious for Envenomations By Southern Pacific Rattlesnakes (Crotalus Helleri). Ann Emerg Med. 2002;40(6):619-24. PubMed PMID: 12447339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crotalidae polyvalent immune Fab (ovine) antivenom is efficacious for envenomations by Southern Pacific rattlesnakes (Crotalus helleri). AU - Bush,Sean P, AU - Green,Steven M, AU - Moynihan,James A, AU - Hayes,William K, AU - Cardwell,Michael D, PY - 2002/11/26/pubmed PY - 2002/12/27/medline PY - 2002/11/26/entrez SP - 619 EP - 24 JF - Annals of emergency medicine JO - Ann Emerg Med VL - 40 IS - 6 N2 - STUDY OBJECTIVE: Southern Pacific rattlesnake (Crotalus helleri) venom is not 1 of the 4 venoms used to produce Crotalidae polyvalent immune Fab (ovine) (CroFab; FabAV). There is currently no published clinical experience regarding the efficacy of this new antivenom for confirmed C helleri envenomation, and animal data suggest greatly diminished efficacy. We assessed the efficacy of FabAV for patients with confirmed C helleri envenomation. METHODS: We conducted a prospective observational study of 23 consecutive rattlesnake envenomations that were treated with FabAV at our center. Patients were excluded if the species of snake could not be confirmed, if FabAV antivenom was not given, or if Antivenin (Crotalidae) polyvalent (equine) was given. We collected serial physical examination and laboratory data over a 24-hour period to serially evaluate the severity score and performed follow-up to evaluate delayed reactions. RESULTS: There were 15 patients who received FabAV and had the species of rattlesnake confirmed (9 C helleri, 4 C scutulatus scutulatus, 1 C mitchellii pyrrhus, 1 C ruber ruber). C helleri envenomations demonstrated similar improvement in serial snakebite severity scores to those of other species. Three patients treated with scheduled dosing had recurrence of progressive swelling (2 C helleri and 1 C mitchellii pyrrhus) during the 24-hour study period. CONCLUSION: We observed similar improvement in FabAV-treated patients with C helleri envenomation compared with those of other species and conclude that this treatment in standard doses appears efficacious for bites by this species. Progressive swelling may recur despite scheduled dosing. SN - 0196-0644 UR - https://www.unboundmedicine.com/medline/citation/12447339/Crotalidae_polyvalent_immune_Fab__ovine__antivenom_is_efficacious_for_envenomations_by_Southern_Pacific_rattlesnakes__Crotalus_helleri__ DB - PRIME DP - Unbound Medicine ER -