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Diet and Parkinson's disease: a potential role of dairy products in men.
Ann Neurol 2002; 52(6):793-801AN

Abstract

Diet may play a causative role in Parkinson's disease (PD), but potential associations between diet and PD risk rarely have been assessed in prospective studies. We investigated associations between food intakes and PD risk in two large prospective cohorts in which 210 incident PD cases in men and 184 in women were documented. A positive association was found between dairy intake and PD risk in men (relative risk [RR] comparing extreme categories, 1.8; p trend = 0.004), but not in women (RR, 1.1; p trend = 0.9). No other food groups were associated with PD risk in either men or women. Further analyses among men showed significant positive associations with PD risk for intakes of several dairy foods as well as dairy calcium (RR, 1.5; p trend = 0.02), dairy vitamin D (RR, 1.6; p trend = 0.004), dairy protein (RR, 1.6; p trend = 0.01), and lactose (RR, 1.8; p trend = 0.002), but not dairy fat (RR, 1.1; p trend = 0.4). Intakes of calcium, vitamin D, and protein from other dietary or supplemental sources were not related to PD risk in men. Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. hchen@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12447934

Citation

Chen, Honglei, et al. "Diet and Parkinson's Disease: a Potential Role of Dairy Products in Men." Annals of Neurology, vol. 52, no. 6, 2002, pp. 793-801.
Chen H, Zhang SM, Hernán MA, et al. Diet and Parkinson's disease: a potential role of dairy products in men. Ann Neurol. 2002;52(6):793-801.
Chen, H., Zhang, S. M., Hernán, M. A., Willett, W. C., & Ascherio, A. (2002). Diet and Parkinson's disease: a potential role of dairy products in men. Annals of Neurology, 52(6), pp. 793-801.
Chen H, et al. Diet and Parkinson's Disease: a Potential Role of Dairy Products in Men. Ann Neurol. 2002;52(6):793-801. PubMed PMID: 12447934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and Parkinson's disease: a potential role of dairy products in men. AU - Chen,Honglei, AU - Zhang,Shumin M, AU - Hernán,Miguel A, AU - Willett,Walter C, AU - Ascherio,Alberto, PY - 2002/11/26/pubmed PY - 2002/12/31/medline PY - 2002/11/26/entrez SP - 793 EP - 801 JF - Annals of neurology JO - Ann. Neurol. VL - 52 IS - 6 N2 - Diet may play a causative role in Parkinson's disease (PD), but potential associations between diet and PD risk rarely have been assessed in prospective studies. We investigated associations between food intakes and PD risk in two large prospective cohorts in which 210 incident PD cases in men and 184 in women were documented. A positive association was found between dairy intake and PD risk in men (relative risk [RR] comparing extreme categories, 1.8; p trend = 0.004), but not in women (RR, 1.1; p trend = 0.9). No other food groups were associated with PD risk in either men or women. Further analyses among men showed significant positive associations with PD risk for intakes of several dairy foods as well as dairy calcium (RR, 1.5; p trend = 0.02), dairy vitamin D (RR, 1.6; p trend = 0.004), dairy protein (RR, 1.6; p trend = 0.01), and lactose (RR, 1.8; p trend = 0.002), but not dairy fat (RR, 1.1; p trend = 0.4). Intakes of calcium, vitamin D, and protein from other dietary or supplemental sources were not related to PD risk in men. Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/12447934/Diet_and_Parkinson's_disease:_a_potential_role_of_dairy_products_in_men_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2002&volume=52&issue=6&spage=793 DB - PRIME DP - Unbound Medicine ER -