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Effects of prune consumption on the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone.

Abstract

BACKGROUND

A higher urinary ratio of the biologically inactive estrogen metabolite, 2-hydroxyestrone (2OHE1), to the biologically active metabolite, 16alpha-hydroxyestrone (16alphaOHE1), may be associated with a lower risk of breast cancer. High fiber intake is also associated with decreased breast cancer risk.

OBJECTIVE

We investigated the effects of prunes, which are naturally rich in both soluble and insoluble fiber, on the concentrations of 2OHE1 and 16alphaOHE1 and on the ratio of 2OHE1 to 16alphaOHE1.

DESIGN

Nineteen healthy premenopausal women consumed their habitual diets for 3 menstrual cycles and then consumed 100 g prunes/d for the next 3 cycles. Concentrations of urinary 2OHE1 and 16alphaOHE1 were determined during the follicular and luteal phases.

RESULTS

Prune supplementation increased total and soluble fiber intakes by 4 and 2 g/d, respectively (P < 0.001). Mean (+/- SEM) luteal 2OHE1 excretion decreased from 3.92 +/- 0.79 to 2.20 +/- 0.40 nmol/mmol creatinine during the third cycle (P = 0.017). Luteal 16alphaOHE1 excretion decreased from 1.38 +/- 0.24 to 0.87 +/- 0.10 and 0.87 +/- 0.15 nmol/mmol creatinine during the first and third cycles, respectively (P = 0.018 for both values). Follicular 16alphaOHE1 excretion decreased significantly only during the first cycle (from 0.82 +/- 0.12 to 0.45 +/- 0.09 nmol/mmol creatinine; P = 0.005). The 2OHE1-16alphaOHE1 ratio did not change significantly after prune supplementation.

CONCLUSIONS

Prune supplementation significantly decreased the excretion of 16alphaOHE1 during the follicular phase of the first menstrual cycle and during the luteal phases of both the first and third menstrual cycles. The 2OHE1-16alphaOHE1 ratio did not change significantly. The potential significance of the decrease in 16alphaOHE1 excretion, without a change in the 2OHE1-16alphaOHE1 ratio, on the prevention of estrogen-dependent cancers remains to be determined.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California, Davis, CA 95817, USA. sekarakas@ucdavis.edu

    , , , ,

    Source

    MeSH

    Body Composition
    Body Constitution
    Body Mass Index
    Body Weight
    Diet
    Dietary Carbohydrates
    Dietary Fats
    Dietary Fiber
    Dietary Proteins
    Energy Intake
    Follicular Phase
    Fruit
    Hydroxyestrones
    Luteal Phase
    Premenopause
    Prunus

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12450912

    Citation

    Kasim-Karakas, Sidika E., et al. "Effects of Prune Consumption On the Ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone." The American Journal of Clinical Nutrition, vol. 76, no. 6, 2002, pp. 1422-7.
    Kasim-Karakas SE, Almario RU, Gregory L, et al. Effects of prune consumption on the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone. Am J Clin Nutr. 2002;76(6):1422-7.
    Kasim-Karakas, S. E., Almario, R. U., Gregory, L., Todd, H., Wong, R., & Lasley, B. L. (2002). Effects of prune consumption on the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone. The American Journal of Clinical Nutrition, 76(6), pp. 1422-7.
    Kasim-Karakas SE, et al. Effects of Prune Consumption On the Ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone. Am J Clin Nutr. 2002;76(6):1422-7. PubMed PMID: 12450912.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of prune consumption on the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone. AU - Kasim-Karakas,Sidika E, AU - Almario,Rogelio U, AU - Gregory,Laura, AU - Todd,Heather, AU - Wong,Rodney, AU - Lasley,Bill L, PY - 2002/11/27/pubmed PY - 2002/12/21/medline PY - 2002/11/27/entrez SP - 1422 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 76 IS - 6 N2 - BACKGROUND: A higher urinary ratio of the biologically inactive estrogen metabolite, 2-hydroxyestrone (2OHE1), to the biologically active metabolite, 16alpha-hydroxyestrone (16alphaOHE1), may be associated with a lower risk of breast cancer. High fiber intake is also associated with decreased breast cancer risk. OBJECTIVE: We investigated the effects of prunes, which are naturally rich in both soluble and insoluble fiber, on the concentrations of 2OHE1 and 16alphaOHE1 and on the ratio of 2OHE1 to 16alphaOHE1. DESIGN: Nineteen healthy premenopausal women consumed their habitual diets for 3 menstrual cycles and then consumed 100 g prunes/d for the next 3 cycles. Concentrations of urinary 2OHE1 and 16alphaOHE1 were determined during the follicular and luteal phases. RESULTS: Prune supplementation increased total and soluble fiber intakes by 4 and 2 g/d, respectively (P < 0.001). Mean (+/- SEM) luteal 2OHE1 excretion decreased from 3.92 +/- 0.79 to 2.20 +/- 0.40 nmol/mmol creatinine during the third cycle (P = 0.017). Luteal 16alphaOHE1 excretion decreased from 1.38 +/- 0.24 to 0.87 +/- 0.10 and 0.87 +/- 0.15 nmol/mmol creatinine during the first and third cycles, respectively (P = 0.018 for both values). Follicular 16alphaOHE1 excretion decreased significantly only during the first cycle (from 0.82 +/- 0.12 to 0.45 +/- 0.09 nmol/mmol creatinine; P = 0.005). The 2OHE1-16alphaOHE1 ratio did not change significantly after prune supplementation. CONCLUSIONS: Prune supplementation significantly decreased the excretion of 16alphaOHE1 during the follicular phase of the first menstrual cycle and during the luteal phases of both the first and third menstrual cycles. The 2OHE1-16alphaOHE1 ratio did not change significantly. The potential significance of the decrease in 16alphaOHE1 excretion, without a change in the 2OHE1-16alphaOHE1 ratio, on the prevention of estrogen-dependent cancers remains to be determined. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12450912/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/76.6.1422 DB - PRIME DP - Unbound Medicine ER -