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The natural history and clinical characteristics of aspirin-exacerbated respiratory disease.
Ann Allergy Asthma Immunol. 2002 Nov; 89(5):474-8.AA

Abstract

BACKGROUND

Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinitis, nasal polyps, asthma, and precipitation of asthma and rhinitis attacks after ingestion of aspirin (ASA) and most nonsteroidal anti-inflammatory drugs (NSAIDs). Most information about the disease in the United States has come from small samples of patients.

OBJECTIVE

The purpose of this study was to examine the natural history and clinical characteristics of 300 AERD patients, referred to our institution for aspirin desensitization.

METHODS

All potential AERD patients were evaluated using a standard questionnaire that included information about clinical characteristics and natural progression of their disease, previous history of reactions to ASA and other NSAIDs, current use of medications, and ethnic backgrounds. All patients underwent oral ASA challenges to prove they had AERD.

RESULTS

From patients' history we found that the average age at onset of AERD was 34 years, and that 57% were female. Counting ASA as an NSAID, 33% had previously reacted on two occasions to NSAIDs and 36% on more than three occasions to NSAIDs, whereas only 27% had reacted to one NSAID before they came to us for evaluation. Our patients had averaged 5.5 episodes of sinusitis per year. There were no significant differences in the clinical characteristics or use of medications between genders. Ethnicity was heterogeneous in most participants.

CONCLUSIONS

AERD begins in the third decade of life and in both sexes. The disease progressed over the 13 years between historical onset and current evaluation, with more sinusitis and need for controller medications over time. There was no ethnic or familial distribution of AERD.

Authors+Show Affiliations

Scripps Clinic, La Jolla, California 92037, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12452205

Citation

Berges-Gimeno, M Pilar, et al. "The Natural History and Clinical Characteristics of Aspirin-exacerbated Respiratory Disease." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 89, no. 5, 2002, pp. 474-8.
Berges-Gimeno MP, Simon RA, Stevenson DD. The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2002;89(5):474-8.
Berges-Gimeno, M. P., Simon, R. A., & Stevenson, D. D. (2002). The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 89(5), 474-8.
Berges-Gimeno MP, Simon RA, Stevenson DD. The Natural History and Clinical Characteristics of Aspirin-exacerbated Respiratory Disease. Ann Allergy Asthma Immunol. 2002;89(5):474-8. PubMed PMID: 12452205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. AU - Berges-Gimeno,M Pilar, AU - Simon,Ronald A, AU - Stevenson,Donald D, PY - 2002/11/28/pubmed PY - 2002/12/5/medline PY - 2002/11/28/entrez SP - 474 EP - 8 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 89 IS - 5 N2 - BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinitis, nasal polyps, asthma, and precipitation of asthma and rhinitis attacks after ingestion of aspirin (ASA) and most nonsteroidal anti-inflammatory drugs (NSAIDs). Most information about the disease in the United States has come from small samples of patients. OBJECTIVE: The purpose of this study was to examine the natural history and clinical characteristics of 300 AERD patients, referred to our institution for aspirin desensitization. METHODS: All potential AERD patients were evaluated using a standard questionnaire that included information about clinical characteristics and natural progression of their disease, previous history of reactions to ASA and other NSAIDs, current use of medications, and ethnic backgrounds. All patients underwent oral ASA challenges to prove they had AERD. RESULTS: From patients' history we found that the average age at onset of AERD was 34 years, and that 57% were female. Counting ASA as an NSAID, 33% had previously reacted on two occasions to NSAIDs and 36% on more than three occasions to NSAIDs, whereas only 27% had reacted to one NSAID before they came to us for evaluation. Our patients had averaged 5.5 episodes of sinusitis per year. There were no significant differences in the clinical characteristics or use of medications between genders. Ethnicity was heterogeneous in most participants. CONCLUSIONS: AERD begins in the third decade of life and in both sexes. The disease progressed over the 13 years between historical onset and current evaluation, with more sinusitis and need for controller medications over time. There was no ethnic or familial distribution of AERD. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/12452205/The_natural_history_and_clinical_characteristics_of_aspirin_exacerbated_respiratory_disease_ DB - PRIME DP - Unbound Medicine ER -