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Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects.
Dig Dis Sci. 2002 Nov; 47(11):2531-7.DD

Abstract

To reduce weight, some morbidly obese patients are treated with an intragastric balloon, often resulting in increased reflux symptoms. As transient lower esophageal sphincter relaxations (TLESRs) are the major mechanism underlying reflux and can be reduced by cholecystokinin-A (CCK(A)) blockade, we hypothesized that the CCK(A)-receptor antagonist loxiglumide could reduce gastroesophageal reflux in these subjects. Postprandial manometric studies were performed in 12 obese subjects during infusion of placebo or loxiglumide. Before balloon placement, loxiglumide did not significantly reduce the rate of TLESRs but attenuated the postprandial decrease in LES pressure. After 10 weeks of balloon treatment, loxiglumide significantly reduced the rate of TLESRs. Postprandial LES pressure was significantly increased, whereas the meal-induced decrease in LES pressure was absent. Neither loxiglumide nor balloon placement affected gastroesophageal reflux. In conclusion, CCK(A) receptors play an important role in post-prandial LES pressure decrease and are involved in the reflex pathway underlying the triggering of TLESRs, at least after balloon placement.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12452391

Citation

Hirsch, D P., et al. "Role of CCK(A) Receptors in Postprandial Lower Esophageal Sphincter Function in Morbidly Obese Subjects." Digestive Diseases and Sciences, vol. 47, no. 11, 2002, pp. 2531-7.
Hirsch DP, Mathus-Vliegen EM, Holloway RH, et al. Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects. Dig Dis Sci. 2002;47(11):2531-7.
Hirsch, D. P., Mathus-Vliegen, E. M., Holloway, R. H., Fakhry, N., D'Amato, M., & Boeckxstaens, G. E. (2002). Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects. Digestive Diseases and Sciences, 47(11), 2531-7.
Hirsch DP, et al. Role of CCK(A) Receptors in Postprandial Lower Esophageal Sphincter Function in Morbidly Obese Subjects. Dig Dis Sci. 2002;47(11):2531-7. PubMed PMID: 12452391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects. AU - Hirsch,D P, AU - Mathus-Vliegen,E M H, AU - Holloway,R H, AU - Fakhry,N, AU - D'Amato,M, AU - Boeckxstaens,G E E, PY - 2002/11/28/pubmed PY - 2002/12/17/medline PY - 2002/11/28/entrez SP - 2531 EP - 7 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 47 IS - 11 N2 - To reduce weight, some morbidly obese patients are treated with an intragastric balloon, often resulting in increased reflux symptoms. As transient lower esophageal sphincter relaxations (TLESRs) are the major mechanism underlying reflux and can be reduced by cholecystokinin-A (CCK(A)) blockade, we hypothesized that the CCK(A)-receptor antagonist loxiglumide could reduce gastroesophageal reflux in these subjects. Postprandial manometric studies were performed in 12 obese subjects during infusion of placebo or loxiglumide. Before balloon placement, loxiglumide did not significantly reduce the rate of TLESRs but attenuated the postprandial decrease in LES pressure. After 10 weeks of balloon treatment, loxiglumide significantly reduced the rate of TLESRs. Postprandial LES pressure was significantly increased, whereas the meal-induced decrease in LES pressure was absent. Neither loxiglumide nor balloon placement affected gastroesophageal reflux. In conclusion, CCK(A) receptors play an important role in post-prandial LES pressure decrease and are involved in the reflex pathway underlying the triggering of TLESRs, at least after balloon placement. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/12452391/Role_of_CCK_A__receptors_in_postprandial_lower_esophageal_sphincter_function_in_morbidly_obese_subjects_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12452391.ui DB - PRIME DP - Unbound Medicine ER -