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Cytophilic activity in experimental immunologic orchitis in guinea pigs.
Fertil Steril. 1976 Jan; 27(1):21-7.FS

Abstract

Classic experimental immunologic orchitis was induced in guinea pigs by injection of homologous testis homogenate in complete Freund's adjuvant. Blood samples were obtained periodically for 45 days and the animals were hemicastrated on the 8th day after sensitization. By the 8th day, cytophilic activity was found in the serum simultaneously with several foci or orchitis. Significant levels of this activity were found until day 29, but it was absent in animals sensitized with an unrelated antigen or with complete adjuvant alone. Low and transitory levels were detected in some guinea pigs when antigen was administered with incomplete Freund's adjuvant. It is concluded that cytophilic activity is organ-specific and requires complete Freund's adjuvant. Possible implications in experimental immunologic orchitis are discussed.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

1245241

Citation

Barrera, C N., et al. "Cytophilic Activity in Experimental Immunologic Orchitis in Guinea Pigs." Fertility and Sterility, vol. 27, no. 1, 1976, pp. 21-7.
Barrera CN, Mazzolli AB, Mancini RE. Cytophilic activity in experimental immunologic orchitis in guinea pigs. Fertil Steril. 1976;27(1):21-7.
Barrera, C. N., Mazzolli, A. B., & Mancini, R. E. (1976). Cytophilic activity in experimental immunologic orchitis in guinea pigs. Fertility and Sterility, 27(1), 21-7.
Barrera CN, Mazzolli AB, Mancini RE. Cytophilic Activity in Experimental Immunologic Orchitis in Guinea Pigs. Fertil Steril. 1976;27(1):21-7. PubMed PMID: 1245241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytophilic activity in experimental immunologic orchitis in guinea pigs. AU - Barrera,C N, AU - Mazzolli,A B, AU - Mancini,R E, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 21 EP - 7 JF - Fertility and sterility JO - Fertil Steril VL - 27 IS - 1 N2 - Classic experimental immunologic orchitis was induced in guinea pigs by injection of homologous testis homogenate in complete Freund's adjuvant. Blood samples were obtained periodically for 45 days and the animals were hemicastrated on the 8th day after sensitization. By the 8th day, cytophilic activity was found in the serum simultaneously with several foci or orchitis. Significant levels of this activity were found until day 29, but it was absent in animals sensitized with an unrelated antigen or with complete adjuvant alone. Low and transitory levels were detected in some guinea pigs when antigen was administered with incomplete Freund's adjuvant. It is concluded that cytophilic activity is organ-specific and requires complete Freund's adjuvant. Possible implications in experimental immunologic orchitis are discussed. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/1245241/Cytophilic_activity_in_experimental_immunologic_orchitis_in_guinea_pigs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)41591-8 DB - PRIME DP - Unbound Medicine ER -