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Antioxidant and antiproliferative activities of common fruits.
J Agric Food Chem. 2002 Dec 04; 50(25):7449-54.JA

Abstract

Consumption of fruits and vegetables has been associated with reduced risk of chronic diseases such as cardiovascular disease and cancer. Phytochemicals, especially phenolics, in fruits and vegetables are suggested to be the major bioactive compounds for the health benefits. However, the phenolic contents and their antioxidant activities in fruits and vegetables were underestimated in the literature, because bound phenolics were not included. This study was designed to investigate the profiles of total phenolics, including both soluble free and bound forms in common fruits, by applying solvent extraction, base digestion, and solid-phase extraction methods. Cranberry had the highest total phenolic content, followed by apple, red grape, strawberry, pineapple, banana, peach, lemon, orange, pear, and grapefruit. Total antioxidant activity was measured using the TOSC assay. Cranberry had the highest total antioxidant activity (177.0 +/- 4.3 micromol of vitamin C equiv/g of fruit), followed by apple, red grape, strawberry, peach, lemon, pear, banana, orange, grapefruit, and pineapple. Antiproliferation activities were also studied in vitro using HepG(2) human liver-cancer cells, and cranberry showed the highest inhibitory effect with an EC(50) of 14.5 +/- 0.5 mg/mL, followed by lemon, apple, strawberry, red grape, banana, grapefruit, and peach. A bioactivity index (BI) for dietary cancer prevention is proposed to provide a new alternative biomarker for future epidemiological studies in dietary cancer prevention and health promotion.

Authors+Show Affiliations

Sun J
Department of Food Science, Cornell University, Ithaca, New York 14853-7201, USA.
Chu YF
No affiliation info available
Wu X
No affiliation info available
Liu RH
No affiliation info available

MeSH

AnanasAntioxidantsCell DivisionCitrusFragariaFruitGallic AcidMalusMusaPhenolsPlant ExtractsPrunusPyrusVaccinium macrocarponVegetablesVitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12452674

Citation

Sun, Jie, et al. "Antioxidant and Antiproliferative Activities of Common Fruits." Journal of Agricultural and Food Chemistry, vol. 50, no. 25, 2002, pp. 7449-54.
Sun J, Chu YF, Wu X, et al. Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem. 2002;50(25):7449-54.
Sun, J., Chu, Y. F., Wu, X., & Liu, R. H. (2002). Antioxidant and antiproliferative activities of common fruits. Journal of Agricultural and Food Chemistry, 50(25), 7449-54.
Sun J, et al. Antioxidant and Antiproliferative Activities of Common Fruits. J Agric Food Chem. 2002 Dec 4;50(25):7449-54. PubMed PMID: 12452674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and antiproliferative activities of common fruits. AU - Sun,Jie, AU - Chu,Yi-Fang, AU - Wu,Xianzhong, AU - Liu,Rui Hai, PY - 2002/11/28/pubmed PY - 2003/1/15/medline PY - 2002/11/28/entrez SP - 7449 EP - 54 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 50 IS - 25 N2 - Consumption of fruits and vegetables has been associated with reduced risk of chronic diseases such as cardiovascular disease and cancer. Phytochemicals, especially phenolics, in fruits and vegetables are suggested to be the major bioactive compounds for the health benefits. However, the phenolic contents and their antioxidant activities in fruits and vegetables were underestimated in the literature, because bound phenolics were not included. This study was designed to investigate the profiles of total phenolics, including both soluble free and bound forms in common fruits, by applying solvent extraction, base digestion, and solid-phase extraction methods. Cranberry had the highest total phenolic content, followed by apple, red grape, strawberry, pineapple, banana, peach, lemon, orange, pear, and grapefruit. Total antioxidant activity was measured using the TOSC assay. Cranberry had the highest total antioxidant activity (177.0 +/- 4.3 micromol of vitamin C equiv/g of fruit), followed by apple, red grape, strawberry, peach, lemon, pear, banana, orange, grapefruit, and pineapple. Antiproliferation activities were also studied in vitro using HepG(2) human liver-cancer cells, and cranberry showed the highest inhibitory effect with an EC(50) of 14.5 +/- 0.5 mg/mL, followed by lemon, apple, strawberry, red grape, banana, grapefruit, and peach. A bioactivity index (BI) for dietary cancer prevention is proposed to provide a new alternative biomarker for future epidemiological studies in dietary cancer prevention and health promotion. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/12452674/Antioxidant_and_antiproliferative_activities_of_common_fruits_ DB - PRIME DP - Unbound Medicine ER -