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Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases.
Br J Dermatol. 2002 Dec; 147(6):1159-65.BJ

Abstract

BACKGROUND

Penile intraepithelial neoplasia (PIN) is the term used to describe erythroplasia of Queyrat (EQ), Bowen's disease (BD) and bowenoid papulosis (BP). These conditions are distinct clinical entities and have different epidemiological and aetiological associations and prognostic implications.

OBJECTIVES

To describe the presentation and treatment of patients with PIN.

METHODS

Thirty-five patients presenting with PIN over a 7-year period are described.

RESULTS

Our observations include: (i) patients with BP are younger than those with EQ or BD and sometimes have a history of immunosuppression; (ii) patients with BP usually have a history or clinical evidence of previous genital human papillomavirus infection; (iii) patients with EQ often have a concurrent penile dermatosis (lichen sclerosus or lichen planus); (iv) patients with PIN are usually uncircumcised; and (v) response to treatment of BP depends on the integrity of the immune system.

CONCLUSIONS

We recommend vigorous treatment of all patients with PIN, including circumcision. Smoking should be actively discouraged. Patients should have life-long follow-up and partners of patients with BP should be screened for other forms of intraepithelial neoplasia (cervical and anal).

Authors+Show Affiliations

Department of Dermatology, Chelsea and Westminster Hospital, Imperial College School of Medicine, London SW10 9NH, UK. William.Porter@gloucr-tr.swest.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12452865

Citation

Porter, W M., et al. "Penile Intraepithelial Neoplasia: Clinical Spectrum and Treatment of 35 Cases." The British Journal of Dermatology, vol. 147, no. 6, 2002, pp. 1159-65.
Porter WM, Francis N, Hawkins D, et al. Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. Br J Dermatol. 2002;147(6):1159-65.
Porter, W. M., Francis, N., Hawkins, D., Dinneen, M., & Bunker, C. B. (2002). Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. The British Journal of Dermatology, 147(6), 1159-65.
Porter WM, et al. Penile Intraepithelial Neoplasia: Clinical Spectrum and Treatment of 35 Cases. Br J Dermatol. 2002;147(6):1159-65. PubMed PMID: 12452865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. AU - Porter,W M, AU - Francis,N, AU - Hawkins,D, AU - Dinneen,M, AU - Bunker,C B, PY - 2002/11/28/pubmed PY - 2003/2/14/medline PY - 2002/11/28/entrez SP - 1159 EP - 65 JF - The British journal of dermatology JO - Br J Dermatol VL - 147 IS - 6 N2 - BACKGROUND: Penile intraepithelial neoplasia (PIN) is the term used to describe erythroplasia of Queyrat (EQ), Bowen's disease (BD) and bowenoid papulosis (BP). These conditions are distinct clinical entities and have different epidemiological and aetiological associations and prognostic implications. OBJECTIVES: To describe the presentation and treatment of patients with PIN. METHODS: Thirty-five patients presenting with PIN over a 7-year period are described. RESULTS: Our observations include: (i) patients with BP are younger than those with EQ or BD and sometimes have a history of immunosuppression; (ii) patients with BP usually have a history or clinical evidence of previous genital human papillomavirus infection; (iii) patients with EQ often have a concurrent penile dermatosis (lichen sclerosus or lichen planus); (iv) patients with PIN are usually uncircumcised; and (v) response to treatment of BP depends on the integrity of the immune system. CONCLUSIONS: We recommend vigorous treatment of all patients with PIN, including circumcision. Smoking should be actively discouraged. Patients should have life-long follow-up and partners of patients with BP should be screened for other forms of intraepithelial neoplasia (cervical and anal). SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/12452865/Penile_intraepithelial_neoplasia:_clinical_spectrum_and_treatment_of_35_cases_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=2002&volume=147&issue=6&spage=1159 DB - PRIME DP - Unbound Medicine ER -