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Clinical effectiveness of a new antacid chewing gum on heartburn and oesophageal pH control.
Aliment Pharmacol Ther. 2002 Dec; 16(12):2029-35.AP

Abstract

BACKGROUND

Oesophageal acid neutralization with antacids depends on the duration of oesophageal antacid exposure and acid neutralizing capacity. A gum that releases antacid as it is chewed could take advantage of both mechanisms to enhance heartburn relief.

METHODS

Twenty-four subjects were crossed over to four regimens: placebo, chewable antacid tablets (1000 mg CaCO3), lower dose gum (600 mg CaCO3) and higher dose gum (900 mg CaCO3). A dual pH probe was placed, subjects ate a standardized provocative meal and self-dosed once as needed. Symptoms were recorded every 15 min using visual analogue and Likert scales.

SYMPTOMS

Both gums decreased heartburn compared to placebo for 120 min. Higher dose gum decreased heartburn more than chewable antacids up to 120 min post-dose. pH: Active chewable antacid and gums immediately increased oesophageal pH, with significant improvement 15-30 min post-dose.

SUMMARY

(i) both gums promptly decreased heartburn and elevated oesophageal pH; (ii) both gums provided sustained relief for 120 min; (iii) antacid gums provided faster and more prolonged symptom relief and pH control than chewable antacids.

CONCLUSIONS

Calcium carbonate gum effectively neutralizes oesophageal acidity and relieves symptoms following a meal, and is superior to chewable antacids in terms of the duration of heartburn relief.

Authors+Show Affiliations

Oklahoma Foundation for Digestive Research, Oklahoma City 73104, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12452946

Citation

Collings, K L., et al. "Clinical Effectiveness of a New Antacid Chewing Gum On Heartburn and Oesophageal pH Control." Alimentary Pharmacology & Therapeutics, vol. 16, no. 12, 2002, pp. 2029-35.
Collings KL, Rodriguez-Stanley S, Proskin HM, et al. Clinical effectiveness of a new antacid chewing gum on heartburn and oesophageal pH control. Aliment Pharmacol Ther. 2002;16(12):2029-35.
Collings, K. L., Rodriguez-Stanley, S., Proskin, H. M., Robinson, M., & Miner, P. B. (2002). Clinical effectiveness of a new antacid chewing gum on heartburn and oesophageal pH control. Alimentary Pharmacology & Therapeutics, 16(12), 2029-35.
Collings KL, et al. Clinical Effectiveness of a New Antacid Chewing Gum On Heartburn and Oesophageal pH Control. Aliment Pharmacol Ther. 2002;16(12):2029-35. PubMed PMID: 12452946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical effectiveness of a new antacid chewing gum on heartburn and oesophageal pH control. AU - Collings,K L, AU - Rodriguez-Stanley,S, AU - Proskin,H M, AU - Robinson,M, AU - Miner,P B,Jr PY - 2002/11/28/pubmed PY - 2003/3/26/medline PY - 2002/11/28/entrez SP - 2029 EP - 35 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 16 IS - 12 N2 - BACKGROUND: Oesophageal acid neutralization with antacids depends on the duration of oesophageal antacid exposure and acid neutralizing capacity. A gum that releases antacid as it is chewed could take advantage of both mechanisms to enhance heartburn relief. METHODS: Twenty-four subjects were crossed over to four regimens: placebo, chewable antacid tablets (1000 mg CaCO3), lower dose gum (600 mg CaCO3) and higher dose gum (900 mg CaCO3). A dual pH probe was placed, subjects ate a standardized provocative meal and self-dosed once as needed. Symptoms were recorded every 15 min using visual analogue and Likert scales. SYMPTOMS: Both gums decreased heartburn compared to placebo for 120 min. Higher dose gum decreased heartburn more than chewable antacids up to 120 min post-dose. pH: Active chewable antacid and gums immediately increased oesophageal pH, with significant improvement 15-30 min post-dose. SUMMARY: (i) both gums promptly decreased heartburn and elevated oesophageal pH; (ii) both gums provided sustained relief for 120 min; (iii) antacid gums provided faster and more prolonged symptom relief and pH control than chewable antacids. CONCLUSIONS: Calcium carbonate gum effectively neutralizes oesophageal acidity and relieves symptoms following a meal, and is superior to chewable antacids in terms of the duration of heartburn relief. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/12452946/Clinical_effectiveness_of_a_new_antacid_chewing_gum_on_heartburn_and_oesophageal_pH_control_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2002&volume=16&issue=12&spage=2029 DB - PRIME DP - Unbound Medicine ER -