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The role of structural genes in the pathogenesis of osteoarthritic disorders.
Arthritis Res. 2002; 4(6):337-45.AR

Abstract

Osteoarthritis (OA), one of the most common age-related chronic disorders of articular cartilage, joints, and bone tissue, represents a major public health problem. Genetic studies have identified multiple gene variations associated with an increased risk of OA. These findings suggest that there is a large genetic component to OA and that the disorder belongs in the multigenetic, multifactorial class of genetic diseases. Studies of chondrodysplasias and associated hereditary OA have provided a better understanding of the role of structural genes in the maintenance and repair of articular cartilage, in the regulation of chondrocyte proliferation and gene expression, and in the pathogenesis of OA.

Links

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Authors+Show Affiliations

Reginato AM
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Olsen BR
No affiliation info available

MeSH

Cartilage, ArticularGenesGenetic LinkageGenetic Predisposition to DiseaseMultigene FamilyMutationOsteoarthritis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12453309

Citation

Reginato, Anthony M., and Bjorn R. Olsen. "The Role of Structural Genes in the Pathogenesis of Osteoarthritic Disorders." Arthritis Research, vol. 4, no. 6, 2002, pp. 337-45.
Reginato AM, Olsen BR. The role of structural genes in the pathogenesis of osteoarthritic disorders. Arthritis Res. 2002;4(6):337-45.
Reginato, A. M., & Olsen, B. R. (2002). The role of structural genes in the pathogenesis of osteoarthritic disorders. Arthritis Research, 4(6), 337-45.
Reginato AM, Olsen BR. The Role of Structural Genes in the Pathogenesis of Osteoarthritic Disorders. Arthritis Res. 2002;4(6):337-45. PubMed PMID: 12453309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of structural genes in the pathogenesis of osteoarthritic disorders. AU - Reginato,Anthony M, AU - Olsen,Bjorn R, Y1 - 2002/08/30/ PY - 2002/05/22/received PY - 2002/07/22/revised PY - 2002/07/26/accepted PY - 2002/11/28/pubmed PY - 2003/4/16/medline PY - 2002/11/28/entrez SP - 337 EP - 45 JF - Arthritis research JO - Arthritis Res VL - 4 IS - 6 N2 - Osteoarthritis (OA), one of the most common age-related chronic disorders of articular cartilage, joints, and bone tissue, represents a major public health problem. Genetic studies have identified multiple gene variations associated with an increased risk of OA. These findings suggest that there is a large genetic component to OA and that the disorder belongs in the multigenetic, multifactorial class of genetic diseases. Studies of chondrodysplasias and associated hereditary OA have provided a better understanding of the role of structural genes in the maintenance and repair of articular cartilage, in the regulation of chondrocyte proliferation and gene expression, and in the pathogenesis of OA. SN - 1465-9905 UR - https://www.unboundmedicine.com/medline/citation/12453309/The_role_of_structural_genes_in_the_pathogenesis_of_osteoarthritic_disorders_ DB - PRIME DP - Unbound Medicine ER -