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A prospective study of adiposity and postmenopausal breast cancer risk: the Malmö Diet and Cancer Study.
Int J Cancer 2003; 103(2):246-52IJ

Abstract

High BMI is a well-known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness per se. Using data from the Malmö Diet and Cancer Study, a prospective cohort study, 12,159 postmenopausal women (59.9 +/- 7.7 years) were categorized by quintiles of baseline anthropometric and impedance measures and reported weight change since age 20. RRs from multivariate Cox regression models were calculated. All analyses were adjusted for age, height, smoking, alcohol consumption, occupation, marital status, parity, age at first pregnancy, age at menarche and current hormone use. During the 5.7 years of follow-up, there were 246 incident breast cancer cases. Weight, height, BMI and %BF were positively associated with risk of breast cancer (p(trend) <or= 0.02). %BF showed the strongest association, with an RR of 2.01 (95% CI 1.26-3.21) in the highest vs. lowest quintile. There was significant modification of this association by hormone use, suggesting a greater impact of body fatness among nonusers. Fat distribution was not independently associated with breast cancer risk. Women with weight gain >21 kg (top quintile) had an RR of 1.75 (95% CI 1.11-2.77) compared to women with low weight gain. Breast cancer risk in postmenopausal women is predicted by increased body fat and weight gain. %BF is a more discriminating risk factor for breast cancer incidence than the commonly used BMI.

Authors+Show Affiliations

Department of Medicine, Lund University, Malmö University Hospital, Malmö, Sweden. lahmann@mail.dife.de

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12455040

Citation

Lahmann, Petra H., et al. "A Prospective Study of Adiposity and Postmenopausal Breast Cancer Risk: the Malmö Diet and Cancer Study." International Journal of Cancer, vol. 103, no. 2, 2003, pp. 246-52.
Lahmann PH, Lissner L, Gullberg B, et al. A prospective study of adiposity and postmenopausal breast cancer risk: the Malmö Diet and Cancer Study. Int J Cancer. 2003;103(2):246-52.
Lahmann, P. H., Lissner, L., Gullberg, B., Olsson, H., & Berglund, G. (2003). A prospective study of adiposity and postmenopausal breast cancer risk: the Malmö Diet and Cancer Study. International Journal of Cancer, 103(2), pp. 246-52.
Lahmann PH, et al. A Prospective Study of Adiposity and Postmenopausal Breast Cancer Risk: the Malmö Diet and Cancer Study. Int J Cancer. 2003 Jan 10;103(2):246-52. PubMed PMID: 12455040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of adiposity and postmenopausal breast cancer risk: the Malmö Diet and Cancer Study. AU - Lahmann,Petra H, AU - Lissner,Lauren, AU - Gullberg,Bo, AU - Olsson,Håkan, AU - Berglund,Göran, PY - 2002/11/28/pubmed PY - 2003/1/8/medline PY - 2002/11/28/entrez SP - 246 EP - 52 JF - International journal of cancer JO - Int. J. Cancer VL - 103 IS - 2 N2 - High BMI is a well-known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness per se. Using data from the Malmö Diet and Cancer Study, a prospective cohort study, 12,159 postmenopausal women (59.9 +/- 7.7 years) were categorized by quintiles of baseline anthropometric and impedance measures and reported weight change since age 20. RRs from multivariate Cox regression models were calculated. All analyses were adjusted for age, height, smoking, alcohol consumption, occupation, marital status, parity, age at first pregnancy, age at menarche and current hormone use. During the 5.7 years of follow-up, there were 246 incident breast cancer cases. Weight, height, BMI and %BF were positively associated with risk of breast cancer (p(trend) <or= 0.02). %BF showed the strongest association, with an RR of 2.01 (95% CI 1.26-3.21) in the highest vs. lowest quintile. There was significant modification of this association by hormone use, suggesting a greater impact of body fatness among nonusers. Fat distribution was not independently associated with breast cancer risk. Women with weight gain >21 kg (top quintile) had an RR of 1.75 (95% CI 1.11-2.77) compared to women with low weight gain. Breast cancer risk in postmenopausal women is predicted by increased body fat and weight gain. %BF is a more discriminating risk factor for breast cancer incidence than the commonly used BMI. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/12455040/A_prospective_study_of_adiposity_and_postmenopausal_breast_cancer_risk:_the_Malmö_Diet_and_Cancer_Study_ L2 - https://doi.org/10.1002/ijc.10799 DB - PRIME DP - Unbound Medicine ER -