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Effects of ethanol on an acetaldehyde drug discrimination with a conditioned taste aversion procedure.
Alcohol. 2002 Oct; 28(2):103-9.A

Abstract

The current study was designed to investigate whether ethanol shares stimulus properties with acetaldehyde with the use of a discriminative taste aversion procedure. Animals were trained to discriminate a dose of acetaldehyde (0.2 or 0.3 g/kg, i.p.) from saline in eight consecutive cycles consisting of a pairing day (PD) and three nonpairing days (NPDs). On PDs, all animals were injected with a particular dose of acetaldehyde 30 min before a 20-min limited access to a saccharin solution [0.1% (wt./vol.)] and then injected immediately with either LiCl (0.15 M, 1.8 mEq) or saline. On the three following NPDs, animals were injected with saline and 30 min later were presented with the same saccharin solution for 20 min. All animals in each acetaldehyde training dose group acquired discriminative stimulus control before generalization tests were conducted. Results of generalization tests (ethanol doses of 0.8, 1.2, 1.6, and 2.0 g/kg) revealed that ethanol substituted for acetaldehyde at doses of 1.2 and 1.6 g/kg for both training doses of acetaldehyde. The findings for this study indicate that acetaldehyde and ethanol may share some stimulus properties.

Authors+Show Affiliations

Center for Studies in Behavioral Neurobiology, Concordia University, 1455 de Maisonneuve Blvd, W, H-1013, Quebec, H3G 1M8, Montreal, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12457941

Citation

Van A Redila, , et al. "Effects of Ethanol On an Acetaldehyde Drug Discrimination With a Conditioned Taste Aversion Procedure." Alcohol (Fayetteville, N.Y.), vol. 28, no. 2, 2002, pp. 103-9.
Van A Redila , Aliatas E, Smith BR, et al. Effects of ethanol on an acetaldehyde drug discrimination with a conditioned taste aversion procedure. Alcohol. 2002;28(2):103-9.
Van A Redila, ., Aliatas, E., Smith, B. R., & Amit, Z. (2002). Effects of ethanol on an acetaldehyde drug discrimination with a conditioned taste aversion procedure. Alcohol (Fayetteville, N.Y.), 28(2), 103-9.
Van A Redila , et al. Effects of Ethanol On an Acetaldehyde Drug Discrimination With a Conditioned Taste Aversion Procedure. Alcohol. 2002;28(2):103-9. PubMed PMID: 12457941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ethanol on an acetaldehyde drug discrimination with a conditioned taste aversion procedure. AU - Van A Redila,, AU - Aliatas,Emmanuel, AU - Smith,Brian R, AU - Amit,Zalman, PY - 2002/11/30/pubmed PY - 2003/4/9/medline PY - 2002/11/30/entrez SP - 103 EP - 9 JF - Alcohol (Fayetteville, N.Y.) JO - Alcohol VL - 28 IS - 2 N2 - The current study was designed to investigate whether ethanol shares stimulus properties with acetaldehyde with the use of a discriminative taste aversion procedure. Animals were trained to discriminate a dose of acetaldehyde (0.2 or 0.3 g/kg, i.p.) from saline in eight consecutive cycles consisting of a pairing day (PD) and three nonpairing days (NPDs). On PDs, all animals were injected with a particular dose of acetaldehyde 30 min before a 20-min limited access to a saccharin solution [0.1% (wt./vol.)] and then injected immediately with either LiCl (0.15 M, 1.8 mEq) or saline. On the three following NPDs, animals were injected with saline and 30 min later were presented with the same saccharin solution for 20 min. All animals in each acetaldehyde training dose group acquired discriminative stimulus control before generalization tests were conducted. Results of generalization tests (ethanol doses of 0.8, 1.2, 1.6, and 2.0 g/kg) revealed that ethanol substituted for acetaldehyde at doses of 1.2 and 1.6 g/kg for both training doses of acetaldehyde. The findings for this study indicate that acetaldehyde and ethanol may share some stimulus properties. SN - 0741-8329 UR - https://www.unboundmedicine.com/medline/citation/12457941/Effects_of_ethanol_on_an_acetaldehyde_drug_discrimination_with_a_conditioned_taste_aversion_procedure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741832902002707 DB - PRIME DP - Unbound Medicine ER -