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Visceral leishmaniasis and Coombs' positive hemolytic anemia: a rare association in an infant treated with liposomal amphotericin B.
Turk J Pediatr. 2002 Oct-Dec; 44(4):354-6.TJ

Abstract

Visceral leishmaniasis is a worldwide, disseminated intracellular protozoal infection that usually manifests by fever, hepatosplenomegaly, anemia, thrombocytopenia, leukopenia and hypergammaglobulinemia. Although anemia is a usual finding, Coombs' positive hemolytic anemia has rarely been reported in association with this disease. Pentavalent antimonials have been the preferred treatment for this disease for decades, but increasing numbers of treatment failure with antimony are being reported. Liposomal amphotericin B is a new drug which is highly efficacious in the treatment of visceral leishmaniasis and produces minimal toxicity. Here we report an infant with visceral leishmaniasis associated with Coombs' positive hemolytic anemia who was successfully treated with liposomal amphotericin B.

Authors+Show Affiliations

Dilber E
Department of Pediatrics, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
Erduran E
No affiliation info available
Işik Y
No affiliation info available

MeSH

Amphotericin BAnemia, HemolyticAntiprotozoal AgentsCoombs TestFemaleHumansInfantLeishmaniasis, VisceralLiposomesTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12458816

Citation

Dilber, Embiya, et al. "Visceral Leishmaniasis and Coombs' Positive Hemolytic Anemia: a Rare Association in an Infant Treated With Liposomal Amphotericin B." The Turkish Journal of Pediatrics, vol. 44, no. 4, 2002, pp. 354-6.
Dilber E, Erduran E, Işik Y. Visceral leishmaniasis and Coombs' positive hemolytic anemia: a rare association in an infant treated with liposomal amphotericin B. Turk J Pediatr. 2002;44(4):354-6.
Dilber, E., Erduran, E., & Işik, Y. (2002). Visceral leishmaniasis and Coombs' positive hemolytic anemia: a rare association in an infant treated with liposomal amphotericin B. The Turkish Journal of Pediatrics, 44(4), 354-6.
Dilber E, Erduran E, Işik Y. Visceral Leishmaniasis and Coombs' Positive Hemolytic Anemia: a Rare Association in an Infant Treated With Liposomal Amphotericin B. Turk J Pediatr. 2002 Oct-Dec;44(4):354-6. PubMed PMID: 12458816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visceral leishmaniasis and Coombs' positive hemolytic anemia: a rare association in an infant treated with liposomal amphotericin B. AU - Dilber,Embiya, AU - Erduran,Erol, AU - Işik,Yasemin, PY - 2002/12/3/pubmed PY - 2003/2/5/medline PY - 2002/12/3/entrez SP - 354 EP - 6 JF - The Turkish journal of pediatrics JO - Turk J Pediatr VL - 44 IS - 4 N2 - Visceral leishmaniasis is a worldwide, disseminated intracellular protozoal infection that usually manifests by fever, hepatosplenomegaly, anemia, thrombocytopenia, leukopenia and hypergammaglobulinemia. Although anemia is a usual finding, Coombs' positive hemolytic anemia has rarely been reported in association with this disease. Pentavalent antimonials have been the preferred treatment for this disease for decades, but increasing numbers of treatment failure with antimony are being reported. Liposomal amphotericin B is a new drug which is highly efficacious in the treatment of visceral leishmaniasis and produces minimal toxicity. Here we report an infant with visceral leishmaniasis associated with Coombs' positive hemolytic anemia who was successfully treated with liposomal amphotericin B. SN - 0041-4301 UR - https://www.unboundmedicine.com/medline/citation/12458816/Visceral_leishmaniasis_and_Coombs'_positive_hemolytic_anemia:_a_rare_association_in_an_infant_treated_with_liposomal_amphotericin_B_ DB - PRIME DP - Unbound Medicine ER -