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Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer's disease.

Abstract

Epidemiological and pathogenetic evidences suggest a strong association between vascular risk factors and sporadic Alzheimer's disease (sAD). In agreement with the vascular hypothesis of AD, the role of various candidate genes for atherosclerosis has been investigated, leading to conflicting results. In order to clarify the significance of angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism in a group of patients with sAD, we conducted a case-control study including 149 cases and 149 age and sex matched controls. All subjects were genotyped for ACE and Apolipoprotein E (APOE). There were no significant differences in ACE genotype or allele frequencies between cases and controls, even after stratification for APOE4 carrier status. Our data suggest that the ACE I/D polymorphism is not associated to genetic susceptibility in sAD patients.

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  • Authors+Show Affiliations

    ,

    Department of Neurology and Rehabilitation, Centre for Aging Brain and Dementia, University of Palermo, Palermo, Italy.

    , , , , , , , , ,

    Source

    Neuroscience letters 335:2 2002 Dec 25 pg 147-9

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Apolipoproteins E
    Case-Control Studies
    Female
    Gene Frequency
    Genotype
    Humans
    Male
    Middle Aged
    Peptidyl-Dipeptidase A
    Polymorphism, Genetic
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12459519

    Citation

    Monastero, Roberto, et al. "Lack of Association Between Angiotensin Converting Enzyme Polymorphism and Sporadic Alzheimer's Disease." Neuroscience Letters, vol. 335, no. 2, 2002, pp. 147-9.
    Monastero R, Caldarella R, Mannino M, et al. Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer's disease. Neurosci Lett. 2002;335(2):147-9.
    Monastero, R., Caldarella, R., Mannino, M., Cefalù, A. B., Lopez, G., Noto, D., ... Camarda, R. (2002). Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer's disease. Neuroscience Letters, 335(2), pp. 147-9.
    Monastero R, et al. Lack of Association Between Angiotensin Converting Enzyme Polymorphism and Sporadic Alzheimer's Disease. Neurosci Lett. 2002 Dec 25;335(2):147-9. PubMed PMID: 12459519.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer's disease. AU - Monastero,Roberto, AU - Caldarella,Rosalia, AU - Mannino,Marina, AU - Cefalù,Angelo B, AU - Lopez,Gianluca, AU - Noto,Davide, AU - Camarda,Cecilia, AU - Camarda,Lawrence K C, AU - Notarbartolo,Alberto, AU - Averna,Maurizio R, AU - Camarda,Rosolino, PY - 2002/12/3/pubmed PY - 2003/3/21/medline PY - 2002/12/3/entrez SP - 147 EP - 9 JF - Neuroscience letters JO - Neurosci. Lett. VL - 335 IS - 2 N2 - Epidemiological and pathogenetic evidences suggest a strong association between vascular risk factors and sporadic Alzheimer's disease (sAD). In agreement with the vascular hypothesis of AD, the role of various candidate genes for atherosclerosis has been investigated, leading to conflicting results. In order to clarify the significance of angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism in a group of patients with sAD, we conducted a case-control study including 149 cases and 149 age and sex matched controls. All subjects were genotyped for ACE and Apolipoprotein E (APOE). There were no significant differences in ACE genotype or allele frequencies between cases and controls, even after stratification for APOE4 carrier status. Our data suggest that the ACE I/D polymorphism is not associated to genetic susceptibility in sAD patients. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/12459519/Lack_of_association_between_angiotensin_converting_enzyme_polymorphism_and_sporadic_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394002011825 DB - PRIME DP - Unbound Medicine ER -