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The effectiveness of aerobic and muscle strength training in patients receiving hemodialysis and EPO: a randomized controlled trial.
Am J Kidney Dis. 2002 Dec; 40(6):1219-29.AJ

Abstract

BACKGROUND

Individuals with end-stage renal disease on hemodialysis therapy have reduced aerobic exercise capacity and reduced muscle strength.

METHODS

This was a single-blind, randomized, placebo-controlled trial of an exercise intervention in hemodialysis patients administered erythropoietin. The intervention consisted of progressive resisted isotonic quadriceps and hamstrings exercise and training on a cycle ergometer three times weekly for 12 weeks. Individuals in the control group underwent a nonprogressive program of range-of-motion exercises. Both groups were observed for an additional 5 months without intervention. Outcomes were assessed without knowledge of treatment assignment at baseline, 12 weeks, and 5 months. A healthy age- and sex-matched sample provided comparative data.

RESULTS

Our sample was relatively high functioning, with a mean score on the Physical Function subscale of the Short Form 36 (SF-36) of 76 of 100. At 12 weeks, there were large and statistically significant differences in favor of the experimental group on the submaximal exercise test (14 W; 95% confidence interval, 2 to 26) and muscle strength (45 lb; 95% confidence interval, 9 to 81), but not in the 6-minute walk, symptoms questionnaire, or SF-36. Differences between the intervention and control groups at 12 weeks were not evident on retesting 5 months after the end of the intervention. Compared with the healthy sample, patients were significantly lower functioning on the submaximal exercise test, muscle strength, and 6-minute walk test at baseline.

CONCLUSION

In this high-functioning sample, the exercise program improved physical impairment measures, but had no effect on symptoms or health-related quality of life. The impact on patients with a greater degree of physical dysfunction needs to be rigorously studied.

Authors+Show Affiliations

Physiotherapy Department, St Joseph's Healthcare and McMaster University, Hamilton, Ontario, Canada. depaulv@mcmaster.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12460041

Citation

DePaul, Vince, et al. "The Effectiveness of Aerobic and Muscle Strength Training in Patients Receiving Hemodialysis and EPO: a Randomized Controlled Trial." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 40, no. 6, 2002, pp. 1219-29.
DePaul V, Moreland J, Eager T, et al. The effectiveness of aerobic and muscle strength training in patients receiving hemodialysis and EPO: a randomized controlled trial. Am J Kidney Dis. 2002;40(6):1219-29.
DePaul, V., Moreland, J., Eager, T., & Clase, C. M. (2002). The effectiveness of aerobic and muscle strength training in patients receiving hemodialysis and EPO: a randomized controlled trial. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 40(6), 1219-29.
DePaul V, et al. The Effectiveness of Aerobic and Muscle Strength Training in Patients Receiving Hemodialysis and EPO: a Randomized Controlled Trial. Am J Kidney Dis. 2002;40(6):1219-29. PubMed PMID: 12460041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effectiveness of aerobic and muscle strength training in patients receiving hemodialysis and EPO: a randomized controlled trial. AU - DePaul,Vince, AU - Moreland,Julie, AU - Eager,Tom, AU - Clase,Catherine M, PY - 2002/12/3/pubmed PY - 2002/12/21/medline PY - 2002/12/3/entrez SP - 1219 EP - 29 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 40 IS - 6 N2 - BACKGROUND: Individuals with end-stage renal disease on hemodialysis therapy have reduced aerobic exercise capacity and reduced muscle strength. METHODS: This was a single-blind, randomized, placebo-controlled trial of an exercise intervention in hemodialysis patients administered erythropoietin. The intervention consisted of progressive resisted isotonic quadriceps and hamstrings exercise and training on a cycle ergometer three times weekly for 12 weeks. Individuals in the control group underwent a nonprogressive program of range-of-motion exercises. Both groups were observed for an additional 5 months without intervention. Outcomes were assessed without knowledge of treatment assignment at baseline, 12 weeks, and 5 months. A healthy age- and sex-matched sample provided comparative data. RESULTS: Our sample was relatively high functioning, with a mean score on the Physical Function subscale of the Short Form 36 (SF-36) of 76 of 100. At 12 weeks, there were large and statistically significant differences in favor of the experimental group on the submaximal exercise test (14 W; 95% confidence interval, 2 to 26) and muscle strength (45 lb; 95% confidence interval, 9 to 81), but not in the 6-minute walk, symptoms questionnaire, or SF-36. Differences between the intervention and control groups at 12 weeks were not evident on retesting 5 months after the end of the intervention. Compared with the healthy sample, patients were significantly lower functioning on the submaximal exercise test, muscle strength, and 6-minute walk test at baseline. CONCLUSION: In this high-functioning sample, the exercise program improved physical impairment measures, but had no effect on symptoms or health-related quality of life. The impact on patients with a greater degree of physical dysfunction needs to be rigorously studied. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/12460041/The_effectiveness_of_aerobic_and_muscle_strength_training_in_patients_receiving_hemodialysis_and_EPO:_a_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -