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Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors.
Clin Endocrinol (Oxf) 2002; 57(6):751-9CE

Abstract

OBJECTIVE

Increased cardiovascular mortality and carotid atherosclerosis have been observed in hypopituitary patients with untreated GH deficiency (GHD), but results are contradictory and relations to cardiovascular risk factors are not clear. The aim of this study was to investigate intima-media thickness (IMT) in relation to cardiovascular risk factors in adults with GHD.

DESIGN

Cross-sectional observational study of 21 men and 13 women with GHD, but without cardiovascular disease, compared to two healthy control groups matched for age, sex and smoking habits. One control group was matched for body mass index (BMI) and the other group was nonobese.

MEASUREMENTS

IMT of the carotid and femoral arteries, blood pressure, blood samples and anthropometric data.

RESULTS

Patients had 12% thicker composite carotid IMT [(IMT of common carotid artery + IMT of bulb)/2] compared to nonobese controls (P = 0.022), but IMT was not different compared to BMI-matched controls. Femoral IMT did not differ between patients and controls. Patients had higher waist : hip ratio (WHR), heart rate, serum triglycerides and fasting insulin concentrations in combination with lower high-density lipoprotein (HDL) cholesterol and smaller low-density lipoprotein (LDL) peak particle size compared to both nonobese and to BMI-matched controls. This cardiovascular risk pattern was more pronounced in female patients than in male patients compared to their gender controls. Carotid IMT was related to age, serum cholesterol, LDL cholesterol and smoking in the patient group. Only age was independently related to carotid IMT in multivariate analysis.

CONCLUSIONS

These results indicate that high BMI in GH-deficient patients contribute to their increased intima-media thickness. However, several cardiovascular risk factors are present in this patient group independent of their increased BMI, especially in women.

Authors+Show Affiliations

Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12460325

Citation

Leonsson, Maria, et al. "Intima-media Thickness in Cardiovascularly Asymptomatic Hypopituitary Adults With Growth Hormone Deficiency: Relation to Body Mass Index, Gender, and Other Cardiovascular Risk Factors." Clinical Endocrinology, vol. 57, no. 6, 2002, pp. 751-9.
Leonsson M, Hulthe J, Oscarsson J, et al. Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors. Clin Endocrinol (Oxf). 2002;57(6):751-9.
Leonsson, M., Hulthe, J., Oscarsson, J., Johannsson, G., Wendelhag, I., Wikstrand, J., & Bengtsson, B. A. (2002). Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors. Clinical Endocrinology, 57(6), pp. 751-9.
Leonsson M, et al. Intima-media Thickness in Cardiovascularly Asymptomatic Hypopituitary Adults With Growth Hormone Deficiency: Relation to Body Mass Index, Gender, and Other Cardiovascular Risk Factors. Clin Endocrinol (Oxf). 2002;57(6):751-9. PubMed PMID: 12460325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors. AU - Leonsson,Maria, AU - Hulthe,Johannes, AU - Oscarsson,Jan, AU - Johannsson,Gudmundur, AU - Wendelhag,Inger, AU - Wikstrand,John, AU - Bengtsson,Bengt-Ake, PY - 2002/12/4/pubmed PY - 2003/1/31/medline PY - 2002/12/4/entrez SP - 751 EP - 9 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 57 IS - 6 N2 - OBJECTIVE: Increased cardiovascular mortality and carotid atherosclerosis have been observed in hypopituitary patients with untreated GH deficiency (GHD), but results are contradictory and relations to cardiovascular risk factors are not clear. The aim of this study was to investigate intima-media thickness (IMT) in relation to cardiovascular risk factors in adults with GHD. DESIGN: Cross-sectional observational study of 21 men and 13 women with GHD, but without cardiovascular disease, compared to two healthy control groups matched for age, sex and smoking habits. One control group was matched for body mass index (BMI) and the other group was nonobese. MEASUREMENTS: IMT of the carotid and femoral arteries, blood pressure, blood samples and anthropometric data. RESULTS: Patients had 12% thicker composite carotid IMT [(IMT of common carotid artery + IMT of bulb)/2] compared to nonobese controls (P = 0.022), but IMT was not different compared to BMI-matched controls. Femoral IMT did not differ between patients and controls. Patients had higher waist : hip ratio (WHR), heart rate, serum triglycerides and fasting insulin concentrations in combination with lower high-density lipoprotein (HDL) cholesterol and smaller low-density lipoprotein (LDL) peak particle size compared to both nonobese and to BMI-matched controls. This cardiovascular risk pattern was more pronounced in female patients than in male patients compared to their gender controls. Carotid IMT was related to age, serum cholesterol, LDL cholesterol and smoking in the patient group. Only age was independently related to carotid IMT in multivariate analysis. CONCLUSIONS: These results indicate that high BMI in GH-deficient patients contribute to their increased intima-media thickness. However, several cardiovascular risk factors are present in this patient group independent of their increased BMI, especially in women. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/12460325/Intima_media_thickness_in_cardiovascularly_asymptomatic_hypopituitary_adults_with_growth_hormone_deficiency:_relation_to_body_mass_index_gender_and_other_cardiovascular_risk_factors_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=2002&volume=57&issue=6&spage=751 DB - PRIME DP - Unbound Medicine ER -