Tags

Type your tag names separated by a space and hit enter

[Chemosensitivity of Plasmodium falciparum in Sainte Marie island, east coast of Madagascar: in vivo and in vitro studies].
Arch Inst Pasteur Madagascar. 2000; 66(1-2):26-31.AI

Abstract

In order to document the evolution of the chemoresistance of Plasmodium falciparum to chloroquine in Madagascar, a study was carried out in Sainte-Marie island located at 6 km on the eastern border of the country. Symptomatic malaria patients who satisfied criteria for resistance testing, were recruited by a process of passive case detection at two clinics. These patients were enrolled in a sensitivity 14-day in vivo test for uncomplicated P. falciparum malaria attacks. All subjects received a supervised therapeutic regimen of chloroquine (25 mg base/kg over 3 days). Parasitemia and symptoms were monitored for 14 days. 62 (93.9%) out of the 66 enrolled patients completed the 14-day follow-up. A total of 50 of 62 patients (80.6%) presented an adequate clinical response. Early and late treatment failures were observed in 3 (4.8%) and 9 (14.5%) patients respectively. Failure therapeutic treatments treated with sulfadoxine-pyrimethamine were successful. Chloroquine remains effective in the treatment of malaria due to P. falciparum and therefore its choice as a first line drug remains justified. Likewise, guidelines for the use of sulfadoxine-pyrimethamine as second line drug are adequate. In vitro, 4 resistances out of 27 successful tests to chloroquine (14.8%) and 1 resistance out of 25 successful tests to mefloquine (4%) were recorded. No resistance to quinine nor to amodiaquine were noticed. Alternative antimalarial drugs such as quinine, amodiaquine or mefloquine can be used in patients for whom the treatment with chloroquine is not possible. Nevertheless, the level of therapeutic failures to chloroquine detected in this study highlights the need and importance of drug sensitivity test for the development of a rational national antimalarial drug policy.

Authors+Show Affiliations

Institut Pasteur de Madagascar, BP 1274, 101 Antananarivo-Madagascar.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

fre

PubMed ID

12463030

Citation

Raharimalala, A L., et al. "[Chemosensitivity of Plasmodium Falciparum in Sainte Marie Island, East Coast of Madagascar: in Vivo and in Vitro Studies]." Archives De l'Institut Pasteur De Madagascar, vol. 66, no. 1-2, 2000, pp. 26-31.
Raharimalala AL, Randrianarivelojosia M, Randriamanantena A, et al. [Chemosensitivity of Plasmodium falciparum in Sainte Marie island, east coast of Madagascar: in vivo and in vitro studies]. Arch Inst Pasteur Madagascar. 2000;66(1-2):26-31.
Raharimalala, A. L., Randrianarivelojosia, M., Randriamanantena, A., Ranarivelo, L. A., Jaureguiberry, S., Rason, M. A., Rakotomalala, E., & Ariey, F. (2000). [Chemosensitivity of Plasmodium falciparum in Sainte Marie island, east coast of Madagascar: in vivo and in vitro studies]. Archives De l'Institut Pasteur De Madagascar, 66(1-2), 26-31.
Raharimalala AL, et al. [Chemosensitivity of Plasmodium Falciparum in Sainte Marie Island, East Coast of Madagascar: in Vivo and in Vitro Studies]. Arch Inst Pasteur Madagascar. 2000;66(1-2):26-31. PubMed PMID: 12463030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chemosensitivity of Plasmodium falciparum in Sainte Marie island, east coast of Madagascar: in vivo and in vitro studies]. AU - Raharimalala,A L, AU - Randrianarivelojosia,M, AU - Randriamanantena,A, AU - Ranarivelo,L A, AU - Jaureguiberry,S, AU - Rason,M A, AU - Rakotomalala,E, AU - Ariey,F, PY - 2002/12/5/pubmed PY - 2002/12/28/medline PY - 2002/12/5/entrez SP - 26 EP - 31 JF - Archives de l'Institut Pasteur de Madagascar JO - Arch Inst Pasteur Madagascar VL - 66 IS - 1-2 N2 - In order to document the evolution of the chemoresistance of Plasmodium falciparum to chloroquine in Madagascar, a study was carried out in Sainte-Marie island located at 6 km on the eastern border of the country. Symptomatic malaria patients who satisfied criteria for resistance testing, were recruited by a process of passive case detection at two clinics. These patients were enrolled in a sensitivity 14-day in vivo test for uncomplicated P. falciparum malaria attacks. All subjects received a supervised therapeutic regimen of chloroquine (25 mg base/kg over 3 days). Parasitemia and symptoms were monitored for 14 days. 62 (93.9%) out of the 66 enrolled patients completed the 14-day follow-up. A total of 50 of 62 patients (80.6%) presented an adequate clinical response. Early and late treatment failures were observed in 3 (4.8%) and 9 (14.5%) patients respectively. Failure therapeutic treatments treated with sulfadoxine-pyrimethamine were successful. Chloroquine remains effective in the treatment of malaria due to P. falciparum and therefore its choice as a first line drug remains justified. Likewise, guidelines for the use of sulfadoxine-pyrimethamine as second line drug are adequate. In vitro, 4 resistances out of 27 successful tests to chloroquine (14.8%) and 1 resistance out of 25 successful tests to mefloquine (4%) were recorded. No resistance to quinine nor to amodiaquine were noticed. Alternative antimalarial drugs such as quinine, amodiaquine or mefloquine can be used in patients for whom the treatment with chloroquine is not possible. Nevertheless, the level of therapeutic failures to chloroquine detected in this study highlights the need and importance of drug sensitivity test for the development of a rational national antimalarial drug policy. SN - 0020-2495 UR - https://www.unboundmedicine.com/medline/citation/12463030/[Chemosensitivity_of_Plasmodium_falciparum_in_Sainte_Marie_island_east_coast_of_Madagascar:_in_vivo_and_in_vitro_studies]_ DB - PRIME DP - Unbound Medicine ER -