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Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects.
N Engl J Med. 1976 Feb 26; 294(9):455-61.NEJM

Abstract

Glucagon was infused to maintain plasma concentrations three to six times the basal level (300 to 600 pg per milliliter) into 16 normal and seven non-diabetic obese subjects. Hyperglucagonemia caused only a transient rise of 5 to 10 mg per 100 ml in basal glucose levels and had no effect on oral glucose tolerance or plasma insulin. In three patients with adult and two with juvenile-onset diabetes on maintenance insulin, hyperglucagonemia maintained for two to four days caused no change in plasma glucose of ketone concentration. In contrast, in nine insulin-withdrawn patients the glycemic response to hyperglucagonemia was five to 15 times greater (P less then 0.05) than in normal controls. Hyperglucagonemia does not cause glucose intolerance in normal subjects or bring about deterioration of diabetic control when insulin is available. Glucagon in the insulin-deprived patient can worsen the diabetic state. These findings suggest the primary role of insulin deficiency in the diabetogenic action of glucagon.

Authors

Sherwin RS
No affiliation info available
Fisher M
No affiliation info available
Hendler R
No affiliation info available
Felig P
No affiliation info available

MeSH

AdultBlood GlucoseDiabetes MellitusDiabetes Mellitus, Type 1FemaleGlucagonHomeostasisHumansInfusions, ParenteralInsulinMaleMiddle AgedObesity

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1246330

Citation

Sherwin, R S., et al. "Hyperglucagonemia and Blood Glucose Regulation in Normal, Obese and Diabetic Subjects." The New England Journal of Medicine, vol. 294, no. 9, 1976, pp. 455-61.
Sherwin RS, Fisher M, Hendler R, et al. Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects. N Engl J Med. 1976;294(9):455-61.
Sherwin, R. S., Fisher, M., Hendler, R., & Felig, P. (1976). Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects. The New England Journal of Medicine, 294(9), 455-61.
Sherwin RS, et al. Hyperglucagonemia and Blood Glucose Regulation in Normal, Obese and Diabetic Subjects. N Engl J Med. 1976 Feb 26;294(9):455-61. PubMed PMID: 1246330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects. AU - Sherwin,R S, AU - Fisher,M, AU - Hendler,R, AU - Felig,P, PY - 1976/2/26/pubmed PY - 1976/2/26/medline PY - 1976/2/26/entrez SP - 455 EP - 61 JF - The New England journal of medicine JO - N Engl J Med VL - 294 IS - 9 N2 - Glucagon was infused to maintain plasma concentrations three to six times the basal level (300 to 600 pg per milliliter) into 16 normal and seven non-diabetic obese subjects. Hyperglucagonemia caused only a transient rise of 5 to 10 mg per 100 ml in basal glucose levels and had no effect on oral glucose tolerance or plasma insulin. In three patients with adult and two with juvenile-onset diabetes on maintenance insulin, hyperglucagonemia maintained for two to four days caused no change in plasma glucose of ketone concentration. In contrast, in nine insulin-withdrawn patients the glycemic response to hyperglucagonemia was five to 15 times greater (P less then 0.05) than in normal controls. Hyperglucagonemia does not cause glucose intolerance in normal subjects or bring about deterioration of diabetic control when insulin is available. Glucagon in the insulin-deprived patient can worsen the diabetic state. These findings suggest the primary role of insulin deficiency in the diabetogenic action of glucagon. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/1246330/Hyperglucagonemia_and_blood_glucose_regulation_in_normal_obese_and_diabetic_subjects_ DB - PRIME DP - Unbound Medicine ER -