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Rapid diagnosis of iron deficiency by measurement of free erythrocyte porphyrins and hemoglobin: the FEP/hemoglobin ratio.
Pediatrics. 1976 Jan; 57(1):136-41.Ped

Abstract

The concentration of free erythrocyte prophyrins (FEP) and of hemoglobin can be measured on blood samples spotted on filter paper. The FEP/hemoglobin ratio in iron deficiency increases exponentially with a decrease of both transferrin saturation and hemoglobin level. The FEP/hemoglobin is an indicator of imparied heme synthesis. In small children an elevation of the FEP/hemoglobin ratio is a better indicator of iron-deficiency anemia than low transferrin saturation. The FEP/hemoglobin ratio is normal in thalassemia trait and renal anemia but it may be elevated in sickle-cell anemia. Measurement of FEP and hemoglobin on filter paper provides a useful diagnostic tool for the diagnosis of iron deficiency, of anemia, and (in populations at risk) of leas intoxication.

Authors

Piomelli S
No affiliation info available
Brickman A
No affiliation info available
Carlos E
No affiliation info available

MeSH

AdolescentAnemiaAnemia, HypochromicAnemia, Sickle CellChildChild, PreschoolErythrocytesHemoglobinsHumansInfantPorphyrinsThalassemiaTransferrin

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1246489

Citation

Piomelli, S, et al. "Rapid Diagnosis of Iron Deficiency By Measurement of Free Erythrocyte Porphyrins and Hemoglobin: the FEP/hemoglobin Ratio." Pediatrics, vol. 57, no. 1, 1976, pp. 136-41.
Piomelli S, Brickman A, Carlos E. Rapid diagnosis of iron deficiency by measurement of free erythrocyte porphyrins and hemoglobin: the FEP/hemoglobin ratio. Pediatrics. 1976;57(1):136-41.
Piomelli, S., Brickman, A., & Carlos, E. (1976). Rapid diagnosis of iron deficiency by measurement of free erythrocyte porphyrins and hemoglobin: the FEP/hemoglobin ratio. Pediatrics, 57(1), 136-41.
Piomelli S, Brickman A, Carlos E. Rapid Diagnosis of Iron Deficiency By Measurement of Free Erythrocyte Porphyrins and Hemoglobin: the FEP/hemoglobin Ratio. Pediatrics. 1976;57(1):136-41. PubMed PMID: 1246489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid diagnosis of iron deficiency by measurement of free erythrocyte porphyrins and hemoglobin: the FEP/hemoglobin ratio. AU - Piomelli,S, AU - Brickman,A, AU - Carlos,E, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 136 EP - 41 JF - Pediatrics JO - Pediatrics VL - 57 IS - 1 N2 - The concentration of free erythrocyte prophyrins (FEP) and of hemoglobin can be measured on blood samples spotted on filter paper. The FEP/hemoglobin ratio in iron deficiency increases exponentially with a decrease of both transferrin saturation and hemoglobin level. The FEP/hemoglobin is an indicator of imparied heme synthesis. In small children an elevation of the FEP/hemoglobin ratio is a better indicator of iron-deficiency anemia than low transferrin saturation. The FEP/hemoglobin ratio is normal in thalassemia trait and renal anemia but it may be elevated in sickle-cell anemia. Measurement of FEP and hemoglobin on filter paper provides a useful diagnostic tool for the diagnosis of iron deficiency, of anemia, and (in populations at risk) of leas intoxication. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/1246489/Rapid_diagnosis_of_iron_deficiency_by_measurement_of_free_erythrocyte_porphyrins_and_hemoglobin:_the_FEP/hemoglobin_ratio_ DB - PRIME DP - Unbound Medicine ER -