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High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome.
J Clin Endocrinol Metab. 2002 Dec; 87(12):5461-4.JC

Abstract

Prader-Willi syndrome (PWS) is a genetic disorder occurring in 1 of 10,000-16,000 live births and is characterized by excessive appetite with progressive massive obesity as well as short stature and mental retardation. Most patients have GH deficiency and hypogonadotropic hypogonadism. The causes of the hyperphagia and abnormal GH secretion are unknown. To determine whether ghrelin, a novel GH secretagogue with orexigenic properties, is elevated in PWS, we measured fasting plasma ghrelin concentration; body composition (dual-energy x-ray absorptiometry); and subjective ratings of hunger (visual analog scale) in seven subjects (6 males and 1 female; age, 26 +/- 7 yr; body fat, 39 +/- 11%, mean +/- SD) with PWS (diagnosis confirmed by genetic test) and 30 healthy subjects (reference population, 15 males and 15 females; age, 32 +/- 7 yr; body fat, 36 +/- 11%) fasted overnight. All subjects were weight stable for at least 6 months before admission to the study. The mean plasma ghrelin concentration was higher in PWS than in the reference population (307 +/- 164 vs. 109 +/- 24 fmol/ml; P < 0.001), and this difference remained significant after adjustment for percentage body fat (P < 0.001). Plasma ghrelin was also higher (P = 0.0004) in PWS than in five healthy subjects fasted for 36 h. A positive correlation was found between plasma ghrelin and subjective ratings of hunger (r = 0.71; P = 0.008). Furthermore, in subjects with PWS, the concentration of the hormone was not different before and after ingestion of 2 ml and a satiating amount of the same liquid meal (ghrelin concentrations: 307 +/- 164 vs. 306 +/- 205 vs. 260 +/- 134 fmol/ml, respectively; ANOVA for repeated measures, P = 0.56). This is the first evidence that ghrelin, a novel orexigenic hormone, is elevated in subjects with PWS. Our finding suggests that ghrelin may be responsible, at least in part, for the hyperphagia observed in PWS.

Authors+Show Affiliations

Clinical Diabetes and Nutrition Section, National Institutes of Health-National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016, USA. adelpari@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12466337

Citation

DelParigi, Angelo, et al. "High Circulating Ghrelin: a Potential Cause for Hyperphagia and Obesity in Prader-willi Syndrome." The Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 12, 2002, pp. 5461-4.
DelParigi A, Tschöp M, Heiman ML, et al. High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. J Clin Endocrinol Metab. 2002;87(12):5461-4.
DelParigi, A., Tschöp, M., Heiman, M. L., Salbe, A. D., Vozarova, B., Sell, S. M., Bunt, J. C., & Tataranni, P. A. (2002). High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. The Journal of Clinical Endocrinology and Metabolism, 87(12), 5461-4.
DelParigi A, et al. High Circulating Ghrelin: a Potential Cause for Hyperphagia and Obesity in Prader-willi Syndrome. J Clin Endocrinol Metab. 2002;87(12):5461-4. PubMed PMID: 12466337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. AU - DelParigi,Angelo, AU - Tschöp,Matthias, AU - Heiman,Mark L, AU - Salbe,Arline D, AU - Vozarova,Barbora, AU - Sell,Susan M, AU - Bunt,Joy C, AU - Tataranni,P Antonio, PY - 2002/12/6/pubmed PY - 2003/1/18/medline PY - 2002/12/6/entrez SP - 5461 EP - 4 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 87 IS - 12 N2 - Prader-Willi syndrome (PWS) is a genetic disorder occurring in 1 of 10,000-16,000 live births and is characterized by excessive appetite with progressive massive obesity as well as short stature and mental retardation. Most patients have GH deficiency and hypogonadotropic hypogonadism. The causes of the hyperphagia and abnormal GH secretion are unknown. To determine whether ghrelin, a novel GH secretagogue with orexigenic properties, is elevated in PWS, we measured fasting plasma ghrelin concentration; body composition (dual-energy x-ray absorptiometry); and subjective ratings of hunger (visual analog scale) in seven subjects (6 males and 1 female; age, 26 +/- 7 yr; body fat, 39 +/- 11%, mean +/- SD) with PWS (diagnosis confirmed by genetic test) and 30 healthy subjects (reference population, 15 males and 15 females; age, 32 +/- 7 yr; body fat, 36 +/- 11%) fasted overnight. All subjects were weight stable for at least 6 months before admission to the study. The mean plasma ghrelin concentration was higher in PWS than in the reference population (307 +/- 164 vs. 109 +/- 24 fmol/ml; P < 0.001), and this difference remained significant after adjustment for percentage body fat (P < 0.001). Plasma ghrelin was also higher (P = 0.0004) in PWS than in five healthy subjects fasted for 36 h. A positive correlation was found between plasma ghrelin and subjective ratings of hunger (r = 0.71; P = 0.008). Furthermore, in subjects with PWS, the concentration of the hormone was not different before and after ingestion of 2 ml and a satiating amount of the same liquid meal (ghrelin concentrations: 307 +/- 164 vs. 306 +/- 205 vs. 260 +/- 134 fmol/ml, respectively; ANOVA for repeated measures, P = 0.56). This is the first evidence that ghrelin, a novel orexigenic hormone, is elevated in subjects with PWS. Our finding suggests that ghrelin may be responsible, at least in part, for the hyperphagia observed in PWS. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/12466337/High_circulating_ghrelin:_a_potential_cause_for_hyperphagia_and_obesity_in_prader_willi_syndrome_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2002-020871 DB - PRIME DP - Unbound Medicine ER -