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The relationship of reticular basement membrane thickness to airway wall remodeling in asthma.
Am J Respir Crit Care Med. 2002 Dec 15; 166(12 Pt 1):1590-5.AJ

Abstract

Assessment of airway wall remodeling in asthma is difficult in vivo. The thickness of deposited extracellular matrix proteins below the epithelium, the reticular basement membrane, can be assessed by bronchial biopsy of proximal airways. The aim of this study was to determine the relationship between the thickness of the reticular basement membrane in a sample equivalent to a central airway biopsy and the dimensions of the airway wall measured on transverse sections of both central and peripheral airways. Large and small cartilaginous and membranous airways from persons who had died from asthma (fatal asthma, n = 5) or from nonrespiratory causes with asthma (nonfatal asthma, n = 5) or without asthma (control subjects, n = 5) were studied. Reticular basement membrane thickness correlated with the percentage of smooth muscle, submucosal mucous gland, and inner wall area (p < 0.05) in large cartilaginous airways, and with inner wall area and area of smooth muscle (p < 0.01) in small cartilaginous airways, but was not related to airway wall dimensions in membranous airways. These findings show that reticular basement membrane thickness of central airways, which may be assessed by endobronchial biopsy, is correlated with airway remodeling in cartilaginous airways but not with airway wall dimensions of membranous airways.

Authors+Show Affiliations

James AL
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia. ajames@cygnus.uwa.edu.au
Maxwell PS
No affiliation info available
Pearce-Pinto G
No affiliation info available
Elliot JG
No affiliation info available
Carroll NG
No affiliation info available

MeSH

AdultAsthmaBasement MembraneBronchiCase-Control StudiesFemaleHumansMaleMiddle Aged

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12471074

Citation

James, Alan L., et al. "The Relationship of Reticular Basement Membrane Thickness to Airway Wall Remodeling in Asthma." American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 12 Pt 1, 2002, pp. 1590-5.
James AL, Maxwell PS, Pearce-Pinto G, et al. The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. Am J Respir Crit Care Med. 2002;166(12 Pt 1):1590-5.
James, A. L., Maxwell, P. S., Pearce-Pinto, G., Elliot, J. G., & Carroll, N. G. (2002). The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. American Journal of Respiratory and Critical Care Medicine, 166(12 Pt 1), 1590-5.
James AL, et al. The Relationship of Reticular Basement Membrane Thickness to Airway Wall Remodeling in Asthma. Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 1):1590-5. PubMed PMID: 12471074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. AU - James,Alan L, AU - Maxwell,Peta S, AU - Pearce-Pinto,Gladys, AU - Elliot,John G, AU - Carroll,Neil G, PY - 2002/12/10/pubmed PY - 2003/1/8/medline PY - 2002/12/10/entrez SP - 1590 EP - 5 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 166 IS - 12 Pt 1 N2 - Assessment of airway wall remodeling in asthma is difficult in vivo. The thickness of deposited extracellular matrix proteins below the epithelium, the reticular basement membrane, can be assessed by bronchial biopsy of proximal airways. The aim of this study was to determine the relationship between the thickness of the reticular basement membrane in a sample equivalent to a central airway biopsy and the dimensions of the airway wall measured on transverse sections of both central and peripheral airways. Large and small cartilaginous and membranous airways from persons who had died from asthma (fatal asthma, n = 5) or from nonrespiratory causes with asthma (nonfatal asthma, n = 5) or without asthma (control subjects, n = 5) were studied. Reticular basement membrane thickness correlated with the percentage of smooth muscle, submucosal mucous gland, and inner wall area (p < 0.05) in large cartilaginous airways, and with inner wall area and area of smooth muscle (p < 0.01) in small cartilaginous airways, but was not related to airway wall dimensions in membranous airways. These findings show that reticular basement membrane thickness of central airways, which may be assessed by endobronchial biopsy, is correlated with airway remodeling in cartilaginous airways but not with airway wall dimensions of membranous airways. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/12471074/The_relationship_of_reticular_basement_membrane_thickness_to_airway_wall_remodeling_in_asthma_ DB - PRIME DP - Unbound Medicine ER -