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Donovanosis.
Sex Transm Infect. 2002 Dec; 78(6):452-7.ST

Abstract

Donovanosis, a chronic cause of genital ulceration, has recently been the subject of renewed interest after a long period of relative obscurity. The causative organism, Calymmatobacterium granulomatis, has been cultured for the first time in many years and a polymerase chain reaction diagnostic using a colorimetric detection system has been developed. Phylogenetic analysis confirms close similarities with the genus Klebsiella and a proposal made that C granulomatis be reclassified as Klebsiella granulomatis comb nov. Azithromycin has emerged as the drug of choice and should be used if the diagnosis is confirmed or suspected. In donovanosis endemic areas, syndromic management protocols for genital ulceration may need to be adapted locally. A significant donovanosis epidemic was reported in Durban from 1988-97 but the current status of this epidemic is unclear. The donovanosis elimination programme among Aboriginals in Australia appears successful and is a model that could be adopted in other donovanosis endemic areas. Overall, the incidence of donovanosis seems to be decreasing. Increased attention would undoubtedly be paid to donovanosis if policy makers recognised more readily the importance of genital ulcers in fuelling the HIV epidemic.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12473810

Citation

O'Farrell, N. "Donovanosis." Sexually Transmitted Infections, vol. 78, no. 6, 2002, pp. 452-7.
O'Farrell N. Donovanosis. Sex Transm Infect. 2002;78(6):452-7.
O'Farrell, N. (2002). Donovanosis. Sexually Transmitted Infections, 78(6), 452-7.
O'Farrell N. Donovanosis. Sex Transm Infect. 2002;78(6):452-7. PubMed PMID: 12473810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Donovanosis. A1 - O'Farrell,N, PY - 2002/12/11/pubmed PY - 2003/2/21/medline PY - 2002/12/11/entrez SP - 452 EP - 7 JF - Sexually transmitted infections JO - Sex Transm Infect VL - 78 IS - 6 N2 - Donovanosis, a chronic cause of genital ulceration, has recently been the subject of renewed interest after a long period of relative obscurity. The causative organism, Calymmatobacterium granulomatis, has been cultured for the first time in many years and a polymerase chain reaction diagnostic using a colorimetric detection system has been developed. Phylogenetic analysis confirms close similarities with the genus Klebsiella and a proposal made that C granulomatis be reclassified as Klebsiella granulomatis comb nov. Azithromycin has emerged as the drug of choice and should be used if the diagnosis is confirmed or suspected. In donovanosis endemic areas, syndromic management protocols for genital ulceration may need to be adapted locally. A significant donovanosis epidemic was reported in Durban from 1988-97 but the current status of this epidemic is unclear. The donovanosis elimination programme among Aboriginals in Australia appears successful and is a model that could be adopted in other donovanosis endemic areas. Overall, the incidence of donovanosis seems to be decreasing. Increased attention would undoubtedly be paid to donovanosis if policy makers recognised more readily the importance of genital ulcers in fuelling the HIV epidemic. SN - 1368-4973 UR - https://www.unboundmedicine.com/medline/citation/12473810/Donovanosis. L2 - https://sti.bmj.com/lookup/pmidlookup?view=long&pmid=12473810 DB - PRIME DP - Unbound Medicine ER -