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Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution.
J Acquir Immune Defic Syndr 2002; 31(5):514-20JA

Abstract

In this study, we sought to determine the relationship between serum levels of leptin and adiponectin (Acrp30) in patients with HIV-associated lipodystrophy (HIV-LD). Three groups of subjects were studied; HIV-positive subjects with lipodystrophy (HIV-LD; n = 22), HIV-positive subjects without lipodystrophy (HIV; n = 17), and ethnicity- and body mass index-matched healthy control subjects (n = 20). Although total body fat from dual energy x-ray absorptiometry was similar in all three groups, the HIV-LD group had a significantly lower mean proportion of body fat in the limbs +/- SEM (37.2% +/- 2.2%) than either controls (49.8% +/- 1.5%) or HIV subjects (45.7% +/- 2.0%). The HIV-LD group also had the lowest mean insulin sensitivity +/- SEM (5.11 +/- 0.59 mg of glucose/[kg of lean body mass. min] vs. 10.2 +/- 0.72 mg of glucose/[kg of lean body mass. min] in controls and 8.64 +/- 0.69 mg of glucose/[kg of lean body mass. min] in the HIV group). Leptin levels were similar in all three groups and were significantly correlated to total body fat (r = 0.86; p <.001), but these levels did not correlate with either insulin sensitivity or limb fat. Mean Acrp30 levels +/- SEM were lowest in the HIV-LD group (5.43 +/- 0.44 microg/mL vs. 11.2 +/- 1.4 microg/mL in the HIV group and 14.9 +/- 1.8 microg/mL in control subjects). Further, Acrp30 levels were positively correlated with insulin sensitivity (r = 0.610; p <.001) and limb fat (r = 0.483; p <.001). However, the correlation between limb fat and insulin sensitivity disappeared when Acrp30 level and other potential mediators were removed from the association, suggesting that a deficiency in Acrp30 in subjects with HIV-LD may be part of the mechanism for the reduced insulin sensitivity.

Authors+Show Affiliations

Department of Medicine, HSC T15, SUNY at Stony Brook, Stony Brook, NY 11794-8154, USA. dmynarcik@notes.cc.sunysb.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12473840

Citation

Mynarcik, Dennis C., et al. "Adiponectin and Leptin Levels in HIV-infected Subjects With Insulin Resistance and Body Fat Redistribution." Journal of Acquired Immune Deficiency Syndromes (1999), vol. 31, no. 5, 2002, pp. 514-20.
Mynarcik DC, Combs T, McNurlan MA, et al. Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. J Acquir Immune Defic Syndr. 2002;31(5):514-20.
Mynarcik, D. C., Combs, T., McNurlan, M. A., Scherer, P. E., Komaroff, E., & Gelato, M. C. (2002). Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. Journal of Acquired Immune Deficiency Syndromes (1999), 31(5), pp. 514-20.
Mynarcik DC, et al. Adiponectin and Leptin Levels in HIV-infected Subjects With Insulin Resistance and Body Fat Redistribution. J Acquir Immune Defic Syndr. 2002 Dec 15;31(5):514-20. PubMed PMID: 12473840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. AU - Mynarcik,Dennis C, AU - Combs,Terry, AU - McNurlan,Margaret A, AU - Scherer,Philipp E, AU - Komaroff,Eugene, AU - Gelato,Marie C, PY - 2002/12/11/pubmed PY - 2003/1/8/medline PY - 2002/12/11/entrez SP - 514 EP - 20 JF - Journal of acquired immune deficiency syndromes (1999) JO - J. Acquir. Immune Defic. Syndr. VL - 31 IS - 5 N2 - In this study, we sought to determine the relationship between serum levels of leptin and adiponectin (Acrp30) in patients with HIV-associated lipodystrophy (HIV-LD). Three groups of subjects were studied; HIV-positive subjects with lipodystrophy (HIV-LD; n = 22), HIV-positive subjects without lipodystrophy (HIV; n = 17), and ethnicity- and body mass index-matched healthy control subjects (n = 20). Although total body fat from dual energy x-ray absorptiometry was similar in all three groups, the HIV-LD group had a significantly lower mean proportion of body fat in the limbs +/- SEM (37.2% +/- 2.2%) than either controls (49.8% +/- 1.5%) or HIV subjects (45.7% +/- 2.0%). The HIV-LD group also had the lowest mean insulin sensitivity +/- SEM (5.11 +/- 0.59 mg of glucose/[kg of lean body mass. min] vs. 10.2 +/- 0.72 mg of glucose/[kg of lean body mass. min] in controls and 8.64 +/- 0.69 mg of glucose/[kg of lean body mass. min] in the HIV group). Leptin levels were similar in all three groups and were significantly correlated to total body fat (r = 0.86; p <.001), but these levels did not correlate with either insulin sensitivity or limb fat. Mean Acrp30 levels +/- SEM were lowest in the HIV-LD group (5.43 +/- 0.44 microg/mL vs. 11.2 +/- 1.4 microg/mL in the HIV group and 14.9 +/- 1.8 microg/mL in control subjects). Further, Acrp30 levels were positively correlated with insulin sensitivity (r = 0.610; p <.001) and limb fat (r = 0.483; p <.001). However, the correlation between limb fat and insulin sensitivity disappeared when Acrp30 level and other potential mediators were removed from the association, suggesting that a deficiency in Acrp30 in subjects with HIV-LD may be part of the mechanism for the reduced insulin sensitivity. SN - 1525-4135 UR - https://www.unboundmedicine.com/medline/citation/12473840/Adiponectin_and_leptin_levels_in_HIV_infected_subjects_with_insulin_resistance_and_body_fat_redistribution_ L2 - http://Insights.ovid.com/pubmed?pmid=12473840 DB - PRIME DP - Unbound Medicine ER -