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Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors.
Psychopharmacology (Berl). 2002 Dec; 165(1):60-6.P

Abstract

RATIONALE

Indorenate has been proposed to possess antihypertensive, anorectic, stimulus control and anxiolytic-like actions. This compound has affinity mainly for the serotonergic(1A/1B) receptors, hence it could possess antidepressant-like activity.

OBJECTIVES

The general purpose of this study was to explore the possible antidepressant-like effects of the serotonergic compound indorenate in the forced swimming test (FST).

METHODS

In a first approach, a comparison of the actions of several doses of indorenate (2.5, 5.0, 10 mg/kg) with those of other 5-HT(1A) agonists, buspirone (5.0, 10.0 mg/kg) and 8-OH-DPAT (0.25, 0.50, 1.0 mg/kg), was performed in the FST. Secondly, in order to determine the serotonergic receptors that are participating in indorenate's action, different doses of serotonergic antagonists were administered. The compounds used were the 5-HT(1A/1B) and beta-adrenergic antagonist pindolol (2.5, 5.0 mg/kg), the 5-HT(1B)receptor antagonist GR 55562 (0.75, 1.5, 3.0 mg/kg), the 5-HT(1A) antagonist WAY 100635 (0.25, 0.5, 1.0 mg/kg) and the 5-HT(2) antagonist ketanserin (1.0, 2.0, 4.0 mg/kg).

RESULTS

Indorenate (10 mg/kg), 8-OH-DPAT (1.0 mg/kg) and buspirone (5.0 and 10.0 mg/kg) reduced immobility behaviour in the FST, considered as an antidepressant-like effect. Both doses of pindolol (2.5 and 5.0 mg/kg) and WAY 100635 (0.5 and 1.0 mg/kg) antagonised the antidepressant-like effect of indorenate. Neither 5-HT(1B) (GR55562) nor 5-HT(2)(ketanserin) antagonists produced changes in the effect of indorenate in the FST.

CONCLUSIONS

Indorenate produces antidepressant-like actions in the FST that are mediated by the stimulation of 5-HT(1A) receptors.

Authors+Show Affiliations

Subdirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, México 14370, D.F. lucia@imp.edu.mxNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12474119

Citation

Martínez-Mota, Lucía, et al. "Indorenate Produces Antidepressant-like Actions in the Rat Forced Swimming Test Via 5-HT1A Receptors." Psychopharmacology, vol. 165, no. 1, 2002, pp. 60-6.
Martínez-Mota L, Estrada-Camarena E, López-Rubalcava C. Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors. Psychopharmacology (Berl). 2002;165(1):60-6.
Martínez-Mota, L., Estrada-Camarena, E., & López-Rubalcava, C. (2002). Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors. Psychopharmacology, 165(1), 60-6.
Martínez-Mota L, Estrada-Camarena E, López-Rubalcava C. Indorenate Produces Antidepressant-like Actions in the Rat Forced Swimming Test Via 5-HT1A Receptors. Psychopharmacology (Berl). 2002;165(1):60-6. PubMed PMID: 12474119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors. AU - Martínez-Mota,Lucía, AU - Estrada-Camarena,Erika, AU - López-Rubalcava,Carolina, Y1 - 2002/10/23/ PY - 2002/03/21/received PY - 2002/07/13/accepted PY - 2002/12/11/pubmed PY - 2003/3/21/medline PY - 2002/12/11/entrez SP - 60 EP - 6 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 165 IS - 1 N2 - RATIONALE: Indorenate has been proposed to possess antihypertensive, anorectic, stimulus control and anxiolytic-like actions. This compound has affinity mainly for the serotonergic(1A/1B) receptors, hence it could possess antidepressant-like activity. OBJECTIVES: The general purpose of this study was to explore the possible antidepressant-like effects of the serotonergic compound indorenate in the forced swimming test (FST). METHODS: In a first approach, a comparison of the actions of several doses of indorenate (2.5, 5.0, 10 mg/kg) with those of other 5-HT(1A) agonists, buspirone (5.0, 10.0 mg/kg) and 8-OH-DPAT (0.25, 0.50, 1.0 mg/kg), was performed in the FST. Secondly, in order to determine the serotonergic receptors that are participating in indorenate's action, different doses of serotonergic antagonists were administered. The compounds used were the 5-HT(1A/1B) and beta-adrenergic antagonist pindolol (2.5, 5.0 mg/kg), the 5-HT(1B)receptor antagonist GR 55562 (0.75, 1.5, 3.0 mg/kg), the 5-HT(1A) antagonist WAY 100635 (0.25, 0.5, 1.0 mg/kg) and the 5-HT(2) antagonist ketanserin (1.0, 2.0, 4.0 mg/kg). RESULTS: Indorenate (10 mg/kg), 8-OH-DPAT (1.0 mg/kg) and buspirone (5.0 and 10.0 mg/kg) reduced immobility behaviour in the FST, considered as an antidepressant-like effect. Both doses of pindolol (2.5 and 5.0 mg/kg) and WAY 100635 (0.5 and 1.0 mg/kg) antagonised the antidepressant-like effect of indorenate. Neither 5-HT(1B) (GR55562) nor 5-HT(2)(ketanserin) antagonists produced changes in the effect of indorenate in the FST. CONCLUSIONS: Indorenate produces antidepressant-like actions in the FST that are mediated by the stimulation of 5-HT(1A) receptors. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/12474119/Indorenate_produces_antidepressant_like_actions_in_the_rat_forced_swimming_test_via_5_HT1A_receptors_ L2 - https://dx.doi.org/10.1007/s00213-002-1222-z DB - PRIME DP - Unbound Medicine ER -