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[Helicobacter pylori CagA(+) infection in gastric cancer patients].
Pol Merkur Lekarski 2002; 13(75):216-20PM

Abstract

STUDY AIM

The aim of the study was to evaluate the role of Helicobacter pylori CagA(+) infection in gastric cancer.

MATERIAL AND METHODS

475 patients were included into the study (270 gastric cancer patients and 205 control subjects). Helicobacter pylori CagA status was determined by enzyme-linked immunoabsorbent assay (ELISA). The frequency of H. pylori CagA infection in gastric cancer patients and control group was compared. The relationship between presence of anti-H. pylori CagA antibodies and selected clinical and pathomorphological parameters was analysed.

RESULTS

Gastric cancer patients and controls had the same prevalence of H. pylori CagA antibodies (54.4 vs 52.5%; p = 0.078). The persons with H. pylori CagA(+) and CagA(-) were at the same risk for developing gastric cancer (OR = 1.08; 95%CI = 0.66-1.49). However subgroup analysis showed that the risk of gastric cancer development in H. pylori CagA(+) depended on age being 2 times higher for young people (15-40 years) (OR = 2.0; 95% CI = 0-4.25) and four times higher for those under the age of 30 years (OR = 4.0; 95%CI = 0-15.9). There was a positive relationship between H. pylori CagA(+) infection and age (p = 0.043). H. pylori CagA(+) infection was independent of sex, family history of cancers, duration of symptoms, ABO blood group, tumour site, stage, histology and p53 accumulation in cancer gastric tissue.

CONCLUSION

Our study shows that H. pylori CagA(+) infection increases the risk for developing gastric cancer in young persons and does not protect the host against cardia cancer. The results suggest also that infection by H. pylori CagA(+) in gastric cancer has no influence on p53 gene mutation development.

Authors+Show Affiliations

Klinika Gastroenterologii Pomorskiej Akademii Medycznej w Szczecinie.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

12474574

Citation

Ławniczak, MaŁgorzata, and Teresa Starzyńska. "[Helicobacter Pylori CagA(+) Infection in Gastric Cancer Patients]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 13, no. 75, 2002, pp. 216-20.
Ławniczak M, Starzyńska T. [Helicobacter pylori CagA(+) infection in gastric cancer patients]. Pol Merkur Lekarski. 2002;13(75):216-20.
Ławniczak, M., & Starzyńska, T. (2002). [Helicobacter pylori CagA(+) infection in gastric cancer patients]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 13(75), pp. 216-20.
Ławniczak M, Starzyńska T. [Helicobacter Pylori CagA(+) Infection in Gastric Cancer Patients]. Pol Merkur Lekarski. 2002;13(75):216-20. PubMed PMID: 12474574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Helicobacter pylori CagA(+) infection in gastric cancer patients]. AU - Ławniczak,MaŁgorzata, AU - Starzyńska,Teresa, PY - 2002/12/12/pubmed PY - 2003/1/28/medline PY - 2002/12/12/entrez SP - 216 EP - 20 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 13 IS - 75 N2 - STUDY AIM: The aim of the study was to evaluate the role of Helicobacter pylori CagA(+) infection in gastric cancer. MATERIAL AND METHODS: 475 patients were included into the study (270 gastric cancer patients and 205 control subjects). Helicobacter pylori CagA status was determined by enzyme-linked immunoabsorbent assay (ELISA). The frequency of H. pylori CagA infection in gastric cancer patients and control group was compared. The relationship between presence of anti-H. pylori CagA antibodies and selected clinical and pathomorphological parameters was analysed. RESULTS: Gastric cancer patients and controls had the same prevalence of H. pylori CagA antibodies (54.4 vs 52.5%; p = 0.078). The persons with H. pylori CagA(+) and CagA(-) were at the same risk for developing gastric cancer (OR = 1.08; 95%CI = 0.66-1.49). However subgroup analysis showed that the risk of gastric cancer development in H. pylori CagA(+) depended on age being 2 times higher for young people (15-40 years) (OR = 2.0; 95% CI = 0-4.25) and four times higher for those under the age of 30 years (OR = 4.0; 95%CI = 0-15.9). There was a positive relationship between H. pylori CagA(+) infection and age (p = 0.043). H. pylori CagA(+) infection was independent of sex, family history of cancers, duration of symptoms, ABO blood group, tumour site, stage, histology and p53 accumulation in cancer gastric tissue. CONCLUSION: Our study shows that H. pylori CagA(+) infection increases the risk for developing gastric cancer in young persons and does not protect the host against cardia cancer. The results suggest also that infection by H. pylori CagA(+) in gastric cancer has no influence on p53 gene mutation development. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/12474574/[Helicobacter_pylori_CagA_+__infection_in_gastric_cancer_patients]_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -