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Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study.
Lupus. 2002; 11(11):716-21.L

Abstract

Anti-Ro/SSA antibodies are associated with neonatal lupus but are also considered a possible cause for unexplained pregnancy loss and adverse pregnancy outcome. In a large multicentres cohort study we have prospectively followed 100 anti-Ro/SSA positive women (53 systemic lupus erythematosus (SLE)) during their 122 pregnancies and 107 anti-Ro/SSA negative women (58 SLE) (140 pregnancies). Anti-Ro/SSA antibodies were tested by immunoblot and counterimunoelectrophoresis. Mean gestational age at delivery (38 vs 37.9 weeks), prevalence of pregnancy loss (9.9 vs 18.6%), preterm birth (21.3 vs 13.9%), cesarean sections (49.2 vs 53.4%), premature rupture of membranes (4.9 vs 8.1%), preeclampsia (6.6 vs 8%), intrauterine growth retardation (0 vs 2.3%)and newborns small for gestational age (11.5 vs 5.8%) were similar in anti-Ro/SSA positive and negative SLE mothers; findings were similar in non-SLE women. Two cases of congenital heart block were observed out of 100 anti-Ro/SSA positive women. In conclusion, anti-Ro/SSA antibodies are responsible for congenital heart block but do not affect other pregnancy outcomes, both in SLE and in non-SLE women. The general outcome of these pregnancies is now very good, ifprospectively followed by multidisciplinary teams with ample experience in this field.

Authors+Show Affiliations

abrucato@ospedale-niguarda.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12475001

Citation

Brucato, A, et al. "Pregnancy Outcome in 100 Women With Autoimmune Diseases and anti-Ro/SSA Antibodies: a Prospective Controlled Study." Lupus, vol. 11, no. 11, 2002, pp. 716-21.
Brucato A, Doria A, Frassi M, et al. Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study. Lupus. 2002;11(11):716-21.
Brucato, A., Doria, A., Frassi, M., Castellino, G., Franceschini, F., Faden, D., Pisoni, M. P., Solerte, L., Muscarà, M., Lojacono, A., Motta, M., Cavazzana, I., Ghirardello, A., Vescovi, F., Tombini, V., Cimaz, R., Gambari, P. F., Meroni, P. L., Canesi, B., & Tincani, A. (2002). Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study. Lupus, 11(11), 716-21.
Brucato A, et al. Pregnancy Outcome in 100 Women With Autoimmune Diseases and anti-Ro/SSA Antibodies: a Prospective Controlled Study. Lupus. 2002;11(11):716-21. PubMed PMID: 12475001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study. AU - Brucato,A, AU - Doria,A, AU - Frassi,M, AU - Castellino,G, AU - Franceschini,F, AU - Faden,D, AU - Pisoni,M Pia, AU - Solerte,L, AU - Muscarà,M, AU - Lojacono,A, AU - Motta,M, AU - Cavazzana,I, AU - Ghirardello,A, AU - Vescovi,F, AU - Tombini,V, AU - Cimaz,R, AU - Gambari,P F, AU - Meroni,P L, AU - Canesi,B, AU - Tincani,A, PY - 2002/12/12/pubmed PY - 2003/5/13/medline PY - 2002/12/12/entrez SP - 716 EP - 21 JF - Lupus JO - Lupus VL - 11 IS - 11 N2 - Anti-Ro/SSA antibodies are associated with neonatal lupus but are also considered a possible cause for unexplained pregnancy loss and adverse pregnancy outcome. In a large multicentres cohort study we have prospectively followed 100 anti-Ro/SSA positive women (53 systemic lupus erythematosus (SLE)) during their 122 pregnancies and 107 anti-Ro/SSA negative women (58 SLE) (140 pregnancies). Anti-Ro/SSA antibodies were tested by immunoblot and counterimunoelectrophoresis. Mean gestational age at delivery (38 vs 37.9 weeks), prevalence of pregnancy loss (9.9 vs 18.6%), preterm birth (21.3 vs 13.9%), cesarean sections (49.2 vs 53.4%), premature rupture of membranes (4.9 vs 8.1%), preeclampsia (6.6 vs 8%), intrauterine growth retardation (0 vs 2.3%)and newborns small for gestational age (11.5 vs 5.8%) were similar in anti-Ro/SSA positive and negative SLE mothers; findings were similar in non-SLE women. Two cases of congenital heart block were observed out of 100 anti-Ro/SSA positive women. In conclusion, anti-Ro/SSA antibodies are responsible for congenital heart block but do not affect other pregnancy outcomes, both in SLE and in non-SLE women. The general outcome of these pregnancies is now very good, ifprospectively followed by multidisciplinary teams with ample experience in this field. SN - 0961-2033 UR - https://www.unboundmedicine.com/medline/citation/12475001/Pregnancy_outcome_in_100_women_with_autoimmune_diseases_and_anti_Ro/SSA_antibodies:_a_prospective_controlled_study_ L2 - http://journals.sagepub.com/doi/full/10.1191/0961203302lu252oa?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -