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Fixed-dose combination chemotherapy (Rifater/Rifinah) for active pulmonary tuberculosis in Taiwan: a two-year follow-up.
Int J Tuberc Lung Dis 2002; 6(11):1029-32IJ

Abstract

SETTING

Veterans General Hospital-Taipei, Taiwan.

OBJECTIVE

To assess the efficacy and safety of a fixed-dose combination (FDC) of Rifater (RFT)/Rifinah (RFN) in the treatment of newly diagnosed smear-positive pulmonary tuberculosis.

DESIGN

Patients were randomly assigned to two 6-month short-course chemotherapy regimens. One group of patients was treated with FDCs and another was given the four component drugs (INH, RMP, EMB and PZA) as separate formulations.

RESULTS

The 105 patients enrolled in the study were divided into two treatment groups. Fifty-one patients who had completed treatment without interruption, 26 in the FDC group and 25 in the separate regimen, were eligible for analysis at the end of 2 years. Among the patients with a drug susceptibility test result available, four in the FDC group had bacilli resistant to pyrazinamide. In the separate regimen group, two patients had bacilli resistant to ethambutol and six had bacilli resistant to pyrazinamide. The two regimens were of similar effectiveness with regard to sputum conversion, compliance and radiological improvement. No patient with FDC treatment developed gastointestinal symptoms, visual disturbance or peripheral neuropathy (P < 0.05). However, FDC treatment resulted in drug-induced fever in one patient. One patient (3.8%) in the FDC group relapsed 5 months after completing treatment.

CONCLUSION

This study suggests that the two regimens had similar effectiveness in the treatment of smear-positive pulmonary tuberculosis. However, the fewer adverse drug events among those patients treated with the FDC regimen suggests that it has a better safety profile.

Authors+Show Affiliations

Division of Pulmonary Immunology and Infectious Diseases, Chest Department, Veterans General Hospital-Taipei, School of Medicine, National Yang-Ming University, Taiwan. wjsu@vghtpe.gov.twNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Evaluation Studies
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12475151

Citation

Su, W J., and R P. Perng. "Fixed-dose Combination Chemotherapy (Rifater/Rifinah) for Active Pulmonary Tuberculosis in Taiwan: a Two-year Follow-up." The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, vol. 6, no. 11, 2002, pp. 1029-32.
Su WJ, Perng RP. Fixed-dose combination chemotherapy (Rifater/Rifinah) for active pulmonary tuberculosis in Taiwan: a two-year follow-up. Int J Tuberc Lung Dis. 2002;6(11):1029-32.
Su, W. J., & Perng, R. P. (2002). Fixed-dose combination chemotherapy (Rifater/Rifinah) for active pulmonary tuberculosis in Taiwan: a two-year follow-up. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, 6(11), pp. 1029-32.
Su WJ, Perng RP. Fixed-dose Combination Chemotherapy (Rifater/Rifinah) for Active Pulmonary Tuberculosis in Taiwan: a Two-year Follow-up. Int J Tuberc Lung Dis. 2002;6(11):1029-32. PubMed PMID: 12475151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fixed-dose combination chemotherapy (Rifater/Rifinah) for active pulmonary tuberculosis in Taiwan: a two-year follow-up. AU - Su,W J, AU - Perng,R P, PY - 2002/12/12/pubmed PY - 2003/3/13/medline PY - 2002/12/12/entrez SP - 1029 EP - 32 JF - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease JO - Int. J. Tuberc. Lung Dis. VL - 6 IS - 11 N2 - SETTING: Veterans General Hospital-Taipei, Taiwan. OBJECTIVE: To assess the efficacy and safety of a fixed-dose combination (FDC) of Rifater (RFT)/Rifinah (RFN) in the treatment of newly diagnosed smear-positive pulmonary tuberculosis. DESIGN: Patients were randomly assigned to two 6-month short-course chemotherapy regimens. One group of patients was treated with FDCs and another was given the four component drugs (INH, RMP, EMB and PZA) as separate formulations. RESULTS: The 105 patients enrolled in the study were divided into two treatment groups. Fifty-one patients who had completed treatment without interruption, 26 in the FDC group and 25 in the separate regimen, were eligible for analysis at the end of 2 years. Among the patients with a drug susceptibility test result available, four in the FDC group had bacilli resistant to pyrazinamide. In the separate regimen group, two patients had bacilli resistant to ethambutol and six had bacilli resistant to pyrazinamide. The two regimens were of similar effectiveness with regard to sputum conversion, compliance and radiological improvement. No patient with FDC treatment developed gastointestinal symptoms, visual disturbance or peripheral neuropathy (P < 0.05). However, FDC treatment resulted in drug-induced fever in one patient. One patient (3.8%) in the FDC group relapsed 5 months after completing treatment. CONCLUSION: This study suggests that the two regimens had similar effectiveness in the treatment of smear-positive pulmonary tuberculosis. However, the fewer adverse drug events among those patients treated with the FDC regimen suggests that it has a better safety profile. SN - 1027-3719 UR - https://www.unboundmedicine.com/medline/citation/12475151/Fixed_dose_combination_chemotherapy__Rifater/Rifinah__for_active_pulmonary_tuberculosis_in_Taiwan:_a_two_year_follow_up_ L2 - https://www.ingentaconnect.com/openurl?genre=article&amp;issn=1027-3719&amp;volume=6&amp;issue=11&amp;spage=1029&amp;aulast=Su DB - PRIME DP - Unbound Medicine ER -