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Differential impact of cardiovascular disease (CVD) risk factor clustering on CVD and renal disease among African-American and white patients with type 2 diabetes mellitus.
Ethn Dis. 2002 Fall; 12(4):530-4.ED

Abstract

OBJECTIVES

To determine if clustering of cardiovascular disease (CVD) risk factors has a differential impact on CVD and renal disease among African Americans compared to Whites with type 2 diabetes

DESIGN

Cross-sectional.

METHODS

Prevalent CVD, macroalbuminuria, and CVD risk factors were measured in 323 African-American and White adult patients with type 2 diabetes. CVD risk factors were dichotomized according to standard guidelines. Data were analyzed by race according to the presence of any 3 or more CVD risk factors.

RESULTS

Despite a similar prevalence of hypertension, the prevalence of macroalbuminuria in the presence of 3 or more CVD risk factors tended to be higher among African Americans compared to Whites (28.9% vs 13.6%, P = 0.05). The presence of 3+ CVD risk factors was associated with an odds ratio (OR) of 2.5 (P = 0.001, 95% CI, 1.44-4.27) for macroalbuminuria in African Americans compared to an OR of 1.4 (P = 0.25, 95% CI, 0.78-2.53) in Whites. The race/3+ CVD risk factors interaction was statistically significant (P = 0.007). Conversely, the presence of 3+ risk factors was associated with an OR of 1.6 (P = 0.019, 95% CI, 1.08-2.28) for CVD in Whites compared to an OR of 0.8 (P = .287, 95% CI, 0.54-1.20) in African Americans. The prevalence of any CVD in the presence of 3+ risk factors was 61% and 49% in Whites and African Americans respectively (P = .217). The race/3+ CVD risk factors interaction was statistically significant (P = 0.029).

CONCLUSIONS

These findings suggest that among persons with diabetes, a clustering of 3+ CVD risk factors is more predictive for renal disease among African Americans, and more predictive for CVD in Whites. Further research should clarify the impact of CVD risk factor clustering on the incidence of vascular disease among African Americans and Whites with type 2 diabetes.

Authors+Show Affiliations

Department of Family and Community Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27104, USA. jsummers@wfubmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12477139

Citation

Summerson, John H., et al. "Differential Impact of Cardiovascular Disease (CVD) Risk Factor Clustering On CVD and Renal Disease Among African-American and White Patients With Type 2 Diabetes Mellitus." Ethnicity & Disease, vol. 12, no. 4, 2002, pp. 530-4.
Summerson JH, Bell RA, Konen JC, et al. Differential impact of cardiovascular disease (CVD) risk factor clustering on CVD and renal disease among African-American and white patients with type 2 diabetes mellitus. Ethn Dis. 2002;12(4):530-4.
Summerson, J. H., Bell, R. A., Konen, J. C., & Spangler, J. G. (2002). Differential impact of cardiovascular disease (CVD) risk factor clustering on CVD and renal disease among African-American and white patients with type 2 diabetes mellitus. Ethnicity & Disease, 12(4), 530-4.
Summerson JH, et al. Differential Impact of Cardiovascular Disease (CVD) Risk Factor Clustering On CVD and Renal Disease Among African-American and White Patients With Type 2 Diabetes Mellitus. Ethn Dis. 2002;12(4):530-4. PubMed PMID: 12477139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential impact of cardiovascular disease (CVD) risk factor clustering on CVD and renal disease among African-American and white patients with type 2 diabetes mellitus. AU - Summerson,John H, AU - Bell,Ronny A, AU - Konen,Joseph C, AU - Spangler,John G, PY - 2002/12/13/pubmed PY - 2003/3/8/medline PY - 2002/12/13/entrez SP - 530 EP - 4 JF - Ethnicity & disease JO - Ethn Dis VL - 12 IS - 4 N2 - OBJECTIVES: To determine if clustering of cardiovascular disease (CVD) risk factors has a differential impact on CVD and renal disease among African Americans compared to Whites with type 2 diabetes DESIGN: Cross-sectional. METHODS: Prevalent CVD, macroalbuminuria, and CVD risk factors were measured in 323 African-American and White adult patients with type 2 diabetes. CVD risk factors were dichotomized according to standard guidelines. Data were analyzed by race according to the presence of any 3 or more CVD risk factors. RESULTS: Despite a similar prevalence of hypertension, the prevalence of macroalbuminuria in the presence of 3 or more CVD risk factors tended to be higher among African Americans compared to Whites (28.9% vs 13.6%, P = 0.05). The presence of 3+ CVD risk factors was associated with an odds ratio (OR) of 2.5 (P = 0.001, 95% CI, 1.44-4.27) for macroalbuminuria in African Americans compared to an OR of 1.4 (P = 0.25, 95% CI, 0.78-2.53) in Whites. The race/3+ CVD risk factors interaction was statistically significant (P = 0.007). Conversely, the presence of 3+ risk factors was associated with an OR of 1.6 (P = 0.019, 95% CI, 1.08-2.28) for CVD in Whites compared to an OR of 0.8 (P = .287, 95% CI, 0.54-1.20) in African Americans. The prevalence of any CVD in the presence of 3+ risk factors was 61% and 49% in Whites and African Americans respectively (P = .217). The race/3+ CVD risk factors interaction was statistically significant (P = 0.029). CONCLUSIONS: These findings suggest that among persons with diabetes, a clustering of 3+ CVD risk factors is more predictive for renal disease among African Americans, and more predictive for CVD in Whites. Further research should clarify the impact of CVD risk factor clustering on the incidence of vascular disease among African Americans and Whites with type 2 diabetes. SN - 1049-510X UR - https://www.unboundmedicine.com/medline/citation/12477139/Differential_impact_of_cardiovascular_disease__CVD__risk_factor_clustering_on_CVD_and_renal_disease_among_African_American_and_white_patients_with_type_2_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -