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Homocysteine and brain atrophy on MRI of non-demented elderly.
Brain 2003; 126(Pt 1):170-5B

Abstract

Patients with Alzheimer's disease have higher plasma homocysteine levels than controls, but it is uncertain whether higher plasma homocysteine levels are involved in the early pathogenesis of the disease. Hippocampal, amygdalar and global brain atrophy on brain MRI have been proposed as early markers of Alzheimer's disease. In the Rotterdam Scan Study, a population-based study of age-related brain changes in 1077 non-demented people aged 60-90 years, we investigated the association between plasma homocysteine levels and severity of hippocampal, amygdalar and global brain atrophy on MRI. We used axial T(1)-weighted MRIs to visualize global cortical brain atrophy (measured semi-quantitatively; range 0-15) and a 3D HASTE (half-Fourier acquisition single-shot turbo spin echo) sequence in 511 participants to measure hippocampal and amygdalar volumes. We had non-fasting plasma homocysteine levels in 1031 of the participants and in 505 of the participants with hippocampal and amygdalar volumes. Individuals with higher plasma homocysteine levels had, on average, more cortical atrophy [0.23 units (95% CI 0.07-0.38 units) per standard deviation increase in plasma homocysteine levels] and more hippocampal atrophy [difference in left hippocampal volume -0.05 ml (95% CI -0.09 to -0.01) and in right hippocampal volume -0.03 ml (95% CI -0.07 to 0.01) per standard deviation increase in plasma homocysteine levels]. No association was observed between plasma homocysteine levels and amygdalar atrophy. These results support the hypothesis that higher plasma homocysteine levels are associated with more atrophy of the hippocampus and cortical regions in elderly at risk of Alzheimer's disease.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12477704

Citation

den Heijer, T, et al. "Homocysteine and Brain Atrophy On MRI of Non-demented Elderly." Brain : a Journal of Neurology, vol. 126, no. Pt 1, 2003, pp. 170-5.
den Heijer T, Vermeer SE, Clarke R, et al. Homocysteine and brain atrophy on MRI of non-demented elderly. Brain. 2003;126(Pt 1):170-5.
den Heijer, T., Vermeer, S. E., Clarke, R., Oudkerk, M., Koudstaal, P. J., Hofman, A., & Breteler, M. M. (2003). Homocysteine and brain atrophy on MRI of non-demented elderly. Brain : a Journal of Neurology, 126(Pt 1), pp. 170-5.
den Heijer T, et al. Homocysteine and Brain Atrophy On MRI of Non-demented Elderly. Brain. 2003;126(Pt 1):170-5. PubMed PMID: 12477704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine and brain atrophy on MRI of non-demented elderly. AU - den Heijer,T, AU - Vermeer,S E, AU - Clarke,R, AU - Oudkerk,M, AU - Koudstaal,P J, AU - Hofman,A, AU - Breteler,M M B, PY - 2002/12/13/pubmed PY - 2003/3/21/medline PY - 2002/12/13/entrez SP - 170 EP - 5 JF - Brain : a journal of neurology JO - Brain VL - 126 IS - Pt 1 N2 - Patients with Alzheimer's disease have higher plasma homocysteine levels than controls, but it is uncertain whether higher plasma homocysteine levels are involved in the early pathogenesis of the disease. Hippocampal, amygdalar and global brain atrophy on brain MRI have been proposed as early markers of Alzheimer's disease. In the Rotterdam Scan Study, a population-based study of age-related brain changes in 1077 non-demented people aged 60-90 years, we investigated the association between plasma homocysteine levels and severity of hippocampal, amygdalar and global brain atrophy on MRI. We used axial T(1)-weighted MRIs to visualize global cortical brain atrophy (measured semi-quantitatively; range 0-15) and a 3D HASTE (half-Fourier acquisition single-shot turbo spin echo) sequence in 511 participants to measure hippocampal and amygdalar volumes. We had non-fasting plasma homocysteine levels in 1031 of the participants and in 505 of the participants with hippocampal and amygdalar volumes. Individuals with higher plasma homocysteine levels had, on average, more cortical atrophy [0.23 units (95% CI 0.07-0.38 units) per standard deviation increase in plasma homocysteine levels] and more hippocampal atrophy [difference in left hippocampal volume -0.05 ml (95% CI -0.09 to -0.01) and in right hippocampal volume -0.03 ml (95% CI -0.07 to 0.01) per standard deviation increase in plasma homocysteine levels]. No association was observed between plasma homocysteine levels and amygdalar atrophy. These results support the hypothesis that higher plasma homocysteine levels are associated with more atrophy of the hippocampus and cortical regions in elderly at risk of Alzheimer's disease. SN - 0006-8950 UR - https://www.unboundmedicine.com/medline/citation/12477704/full_citation L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awg006 DB - PRIME DP - Unbound Medicine ER -