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E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma.
Ann Diagn Pathol. 2002 Dec; 6(6):349-51.AD

Abstract

Pleomorphic lobular carcinoma is a recently described entity separated from classical lobular carcinoma by cytologic pleomorphism. It can have an aggressive clinical course with a higher frequency of recurrence. Histologic differentiation with ductal carcinoma may be difficult, but it is important for this differentiation to be made. E-cadherin is a transmembrane glycoprotein, and complete loss of E-cadherin expression has been observed in invasive lobular carcinoma and lobular carcinoma in situ. Ductal carcinoma retains at least some expression of E-cadherin. We examined the pattern of E-cadherin expression in a series of 14 cases of pleomorphic lobular carcinoma by immunohistochemistry. Twelve of the 14 cases showed no staining (86%); the remaining two cases exhibited 10% to 25% positive cells. In cases with histologic equivocal features, immunohistochemical detection of E-cadherin expression can be a useful diagnostic aid for the differentiation of pleomorphic lobular and ductal carcinoma.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, TX 77030, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12478484

Citation

Wahed, Amer, et al. "E-cadherin Expression in Pleomorphic Lobular Carcinoma: an Aid to Differentiation From Ductal Carcinoma." Annals of Diagnostic Pathology, vol. 6, no. 6, 2002, pp. 349-51.
Wahed A, Connelly J, Reese T. E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma. Ann Diagn Pathol. 2002;6(6):349-51.
Wahed, A., Connelly, J., & Reese, T. (2002). E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma. Annals of Diagnostic Pathology, 6(6), 349-51.
Wahed A, Connelly J, Reese T. E-cadherin Expression in Pleomorphic Lobular Carcinoma: an Aid to Differentiation From Ductal Carcinoma. Ann Diagn Pathol. 2002;6(6):349-51. PubMed PMID: 12478484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma. AU - Wahed,Amer, AU - Connelly,John, AU - Reese,Tommy, PY - 2002/12/13/pubmed PY - 2003/5/31/medline PY - 2002/12/13/entrez SP - 349 EP - 51 JF - Annals of diagnostic pathology JO - Ann Diagn Pathol VL - 6 IS - 6 N2 - Pleomorphic lobular carcinoma is a recently described entity separated from classical lobular carcinoma by cytologic pleomorphism. It can have an aggressive clinical course with a higher frequency of recurrence. Histologic differentiation with ductal carcinoma may be difficult, but it is important for this differentiation to be made. E-cadherin is a transmembrane glycoprotein, and complete loss of E-cadherin expression has been observed in invasive lobular carcinoma and lobular carcinoma in situ. Ductal carcinoma retains at least some expression of E-cadherin. We examined the pattern of E-cadherin expression in a series of 14 cases of pleomorphic lobular carcinoma by immunohistochemistry. Twelve of the 14 cases showed no staining (86%); the remaining two cases exhibited 10% to 25% positive cells. In cases with histologic equivocal features, immunohistochemical detection of E-cadherin expression can be a useful diagnostic aid for the differentiation of pleomorphic lobular and ductal carcinoma. SN - 1092-9134 UR - https://www.unboundmedicine.com/medline/citation/12478484/E_cadherin_expression_in_pleomorphic_lobular_carcinoma:_an_aid_to_differentiation_from_ductal_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1092913402000503 DB - PRIME DP - Unbound Medicine ER -