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Similarities and differences between Alzheimer's disease and vascular dementia from the viewpoint of nutrition.

Abstract

Dietary habits were compared in patients with Alzheimer's disease (AD) and those with vascular dementia (VaD). Twenty-seven patients with AD, 15 patients with VaD, and 49 age-matched controls were enrolled. Nutritional status was assessed using a semiquantified food-frequency questionnaire. Dietary habits were very similar in male patients with AD and VaD. Both groups had significantly higher energy intake than their energy demands: +25% for AD and +35% for VaD, respectively. However, major sources of energy were different: grains and animal fats for AD versus only grains for VaD. Calculation of nutrients revealed excess intake of n-6 polyunsaturated fatty acids (PUFA) and relative deficiencies of multiple vitamins including antioxidants, vitamin C and carotene, and the vitamin B group. In contrast, dietary habits in female patients with AD differed significantly from those of male patients. Female patients consumed significantly lower amounts of fish and green vegetables. Calculation of nutrients showed absolute deficiencies of n-3 PUFA, multiple vitamins, and minerals. Our results show that AD and VaD are similar from the viewpoint of nutrition, except for the higher consumption of animal fats for AD patients, probably reflecting Westernization of dietary habits in recent years. Nutrition may be relevant to the pathogenesis of dementia through many processes. Higher intake of energy and lower intake of antioxidants may exaggerate the process of dementia through oxidative stress. Excessive amounts of n-6 PUFA or deficiency of n-3 PUFA may cause chronic inflammation, platelet aggregation, or endothelial dysfunction of microvasculature. Nutrition may be useful for preventing dementia, although gender-specific differences must be taken into account.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Jichi Medical School, Omiya Medical Center, 1-847 Amanuma-cho, Saitama City 330-8503, Japan. motsuka@omiya.jichi.ac.jp

    ,

    Source

    MeSH

    Aged
    Alzheimer Disease
    Dementia, Vascular
    Diet
    Energy Intake
    Female
    Humans
    Male
    Micronutrients
    Nutritional Physiological Phenomena
    Reference Values

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    12480746

    Citation

    Otsuka, M, et al. "Similarities and Differences Between Alzheimer's Disease and Vascular Dementia From the Viewpoint of Nutrition." Annals of the New York Academy of Sciences, vol. 977, 2002, pp. 155-61.
    Otsuka M, Yamaguchi K, Ueki A. Similarities and differences between Alzheimer's disease and vascular dementia from the viewpoint of nutrition. Ann N Y Acad Sci. 2002;977:155-61.
    Otsuka, M., Yamaguchi, K., & Ueki, A. (2002). Similarities and differences between Alzheimer's disease and vascular dementia from the viewpoint of nutrition. Annals of the New York Academy of Sciences, 977, pp. 155-61.
    Otsuka M, Yamaguchi K, Ueki A. Similarities and Differences Between Alzheimer's Disease and Vascular Dementia From the Viewpoint of Nutrition. Ann N Y Acad Sci. 2002;977:155-61. PubMed PMID: 12480746.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Similarities and differences between Alzheimer's disease and vascular dementia from the viewpoint of nutrition. AU - Otsuka,M, AU - Yamaguchi,K, AU - Ueki,A, PY - 2002/12/14/pubmed PY - 2003/1/22/medline PY - 2002/12/14/entrez SP - 155 EP - 61 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 977 N2 - Dietary habits were compared in patients with Alzheimer's disease (AD) and those with vascular dementia (VaD). Twenty-seven patients with AD, 15 patients with VaD, and 49 age-matched controls were enrolled. Nutritional status was assessed using a semiquantified food-frequency questionnaire. Dietary habits were very similar in male patients with AD and VaD. Both groups had significantly higher energy intake than their energy demands: +25% for AD and +35% for VaD, respectively. However, major sources of energy were different: grains and animal fats for AD versus only grains for VaD. Calculation of nutrients revealed excess intake of n-6 polyunsaturated fatty acids (PUFA) and relative deficiencies of multiple vitamins including antioxidants, vitamin C and carotene, and the vitamin B group. In contrast, dietary habits in female patients with AD differed significantly from those of male patients. Female patients consumed significantly lower amounts of fish and green vegetables. Calculation of nutrients showed absolute deficiencies of n-3 PUFA, multiple vitamins, and minerals. Our results show that AD and VaD are similar from the viewpoint of nutrition, except for the higher consumption of animal fats for AD patients, probably reflecting Westernization of dietary habits in recent years. Nutrition may be relevant to the pathogenesis of dementia through many processes. Higher intake of energy and lower intake of antioxidants may exaggerate the process of dementia through oxidative stress. Excessive amounts of n-6 PUFA or deficiency of n-3 PUFA may cause chronic inflammation, platelet aggregation, or endothelial dysfunction of microvasculature. Nutrition may be useful for preventing dementia, although gender-specific differences must be taken into account. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/12480746/Similarities_and_differences_between_Alzheimer's_disease_and_vascular_dementia_from_the_viewpoint_of_nutrition_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2002&volume=977&spage=155 DB - PRIME DP - Unbound Medicine ER -