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Intoxication by star fruit (Averrhoa carambola) in 32 uraemic patients: treatment and outcome.
Nephrol Dial Transplant. 2003 Jan; 18(1):120-5.ND

Abstract

BACKGROUND

Clinical symptoms and outcomes of uraemic patients ingesting star fruit are quite variable and may progress to death. The purpose of the present report was to discuss the neurotoxic effects of star fruit intoxication in uraemic patients and to present the efficacy of different therapeutic approaches.

METHODS

We studied a total of 32 uraemic patients who had ingested star fruit. Before the intoxication episodes, 20 patients were on regular haemodialysis, eight were on peritoneal dialysis and four were not yet undergoing dialysis. Two patients were analysed retrospectively from their charts, 17 were directly monitored by our clinic and 13 were referred by physicians from many areas throughout the country, allowing us to follow their outcome from a distance. Intoxicated patients were given different therapeutic approaches (haemodialysis, peritoneal dialysis and supportive treatment), and their outcomes were analysed.

RESULTS

The most common symptoms were persistent and intractable hiccups in 30 patients (93.75%), vomiting in 22 (68.7%), variable degrees of disturbed consciousness (mental confusion, psychomotor agitation) in 21 (65.6%), decreased muscle power, limb numbness, paresis, insomnia and paresthesias in 13 (40.6%) and seizures in seven (21.8%). Patients who were promptly treated with haemodialysis, including those with severe intoxication, recovered without sequelae. Patients with severe intoxication who were not treated or treated with peritoneal dialysis did not survive.

CONCLUSIONS

Haemodialysis, especially on a daily basis, is the ideal treatment for star fruit intoxication. In severe cases, continuous methods of replacement therapy may provide a superior initial procedure, since rebound effects are a common event. Peritoneal dialysis is of no use as a treatment, especially when consciousness disorders ensue.

Authors+Show Affiliations

Nephrology Division of Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil. mmoyses@convex.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12480969

Citation

Neto, Miguel Moyses, et al. "Intoxication By Star Fruit (Averrhoa Carambola) in 32 Uraemic Patients: Treatment and Outcome." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 18, no. 1, 2003, pp. 120-5.
Neto MM, da Costa JA, Garcia-Cairasco N, et al. Intoxication by star fruit (Averrhoa carambola) in 32 uraemic patients: treatment and outcome. Nephrol Dial Transplant. 2003;18(1):120-5.
Neto, M. M., da Costa, J. A., Garcia-Cairasco, N., Netto, J. C., Nakagawa, B., & Dantas, M. (2003). Intoxication by star fruit (Averrhoa carambola) in 32 uraemic patients: treatment and outcome. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 18(1), 120-5.
Neto MM, et al. Intoxication By Star Fruit (Averrhoa Carambola) in 32 Uraemic Patients: Treatment and Outcome. Nephrol Dial Transplant. 2003;18(1):120-5. PubMed PMID: 12480969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intoxication by star fruit (Averrhoa carambola) in 32 uraemic patients: treatment and outcome. AU - Neto,Miguel Moyses, AU - da Costa,José Abrão Cardeal, AU - Garcia-Cairasco,Norberto, AU - Netto,Joaquim Coutinho, AU - Nakagawa,Beatriz, AU - Dantas,Marcio, PY - 2002/12/14/pubmed PY - 2003/7/8/medline PY - 2002/12/14/entrez SP - 120 EP - 5 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 18 IS - 1 N2 - BACKGROUND: Clinical symptoms and outcomes of uraemic patients ingesting star fruit are quite variable and may progress to death. The purpose of the present report was to discuss the neurotoxic effects of star fruit intoxication in uraemic patients and to present the efficacy of different therapeutic approaches. METHODS: We studied a total of 32 uraemic patients who had ingested star fruit. Before the intoxication episodes, 20 patients were on regular haemodialysis, eight were on peritoneal dialysis and four were not yet undergoing dialysis. Two patients were analysed retrospectively from their charts, 17 were directly monitored by our clinic and 13 were referred by physicians from many areas throughout the country, allowing us to follow their outcome from a distance. Intoxicated patients were given different therapeutic approaches (haemodialysis, peritoneal dialysis and supportive treatment), and their outcomes were analysed. RESULTS: The most common symptoms were persistent and intractable hiccups in 30 patients (93.75%), vomiting in 22 (68.7%), variable degrees of disturbed consciousness (mental confusion, psychomotor agitation) in 21 (65.6%), decreased muscle power, limb numbness, paresis, insomnia and paresthesias in 13 (40.6%) and seizures in seven (21.8%). Patients who were promptly treated with haemodialysis, including those with severe intoxication, recovered without sequelae. Patients with severe intoxication who were not treated or treated with peritoneal dialysis did not survive. CONCLUSIONS: Haemodialysis, especially on a daily basis, is the ideal treatment for star fruit intoxication. In severe cases, continuous methods of replacement therapy may provide a superior initial procedure, since rebound effects are a common event. Peritoneal dialysis is of no use as a treatment, especially when consciousness disorders ensue. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/12480969/Intoxication_by_star_fruit__Averrhoa_carambola__in_32_uraemic_patients:_treatment_and_outcome_ DB - PRIME DP - Unbound Medicine ER -