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[Study on plasma coagulation factor VII (FVII) levels and polymorphisms of FVII gene in patients with coronary heart disease].
Zhonghua Xue Ye Xue Za Zhi. 2002 Sep; 23(9):457-9.ZX

Abstract

OBJECTIVE

To investigate the plasma levels of coagulation factor VII (FVII) and polymorphisms of FVII gene in patients with coronary heart disease (CHD), and evaluate the effect of plasma FVII levels and FVII gene polymorphisms on CHD.

METHODS

Plasma FVIIa, FVII: Ag and FVIIc were measured and polymorphisms of FVII gene were analyzed in 149 control cases and 60 CHD cases, including 33 acute myocardial infarction (AMI) cases by a combination of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and agarose gel electrophoresis.

RESULTS

FVIIa, FVIIc in AMI group were significantly higher than that in control group, but FVII: Ag wasn't. There were no significant difference in plasma FVIIa, FVII: Ag and FVIIc between CHD and control group. The IVS7 genotypic frequency in AMI group was significantly different from that in control group. There was no significant difference in genotypic frequencies and allelic frequencies in other polymphism sites. FVII: Ag was significantly higher in -402A homozygote than that in -402G homozygote.

CONCLUSIONS

Increased FVII levels, especially FVIIa and FVIIc in plasma, may contribute to coronary artery thrombosis. There was significant difference in IVS7 genotype frequency between control and AMI groups, but the rest weren't significantly different. FVII: Ag was significantly higher in -402A homozygote than that in -402G homozygote. Polymorphism of -402 G/A may play an indirect role in AMI by regulating plasma FVII levels.

Authors+Show Affiliations

Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12482354

Citation

Kang, Wenying, et al. "[Study On Plasma Coagulation Factor VII (FVII) Levels and Polymorphisms of FVII Gene in Patients With Coronary Heart Disease]." Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, vol. 23, no. 9, 2002, pp. 457-9.
Kang W, Wang H, Xiong L, et al. [Study on plasma coagulation factor VII (FVII) levels and polymorphisms of FVII gene in patients with coronary heart disease]. Zhonghua Xue Ye Xue Za Zhi. 2002;23(9):457-9.
Kang, W., Wang, H., Xiong, L., Wang, X., Chu, H., Qu, B., Liu, X., Yin, J., Duan, B., Yu, J., & Wang, Z. (2002). [Study on plasma coagulation factor VII (FVII) levels and polymorphisms of FVII gene in patients with coronary heart disease]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 23(9), 457-9.
Kang W, et al. [Study On Plasma Coagulation Factor VII (FVII) Levels and Polymorphisms of FVII Gene in Patients With Coronary Heart Disease]. Zhonghua Xue Ye Xue Za Zhi. 2002;23(9):457-9. PubMed PMID: 12482354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on plasma coagulation factor VII (FVII) levels and polymorphisms of FVII gene in patients with coronary heart disease]. AU - Kang,Wenying, AU - Wang,Hongli, AU - Xiong,Lifan, AU - Wang,Xuefeng, AU - Chu,Haiyan, AU - Qu,Bin, AU - Liu,Xiangfan, AU - Yin,Jun, AU - Duan,Baohua, AU - Yu,Jinde, AU - Wang,Zhenyi, PY - 2002/12/17/pubmed PY - 2003/1/17/medline PY - 2002/12/17/entrez SP - 457 EP - 9 JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JO - Zhonghua Xue Ye Xue Za Zhi VL - 23 IS - 9 N2 - OBJECTIVE: To investigate the plasma levels of coagulation factor VII (FVII) and polymorphisms of FVII gene in patients with coronary heart disease (CHD), and evaluate the effect of plasma FVII levels and FVII gene polymorphisms on CHD. METHODS: Plasma FVIIa, FVII: Ag and FVIIc were measured and polymorphisms of FVII gene were analyzed in 149 control cases and 60 CHD cases, including 33 acute myocardial infarction (AMI) cases by a combination of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and agarose gel electrophoresis. RESULTS: FVIIa, FVIIc in AMI group were significantly higher than that in control group, but FVII: Ag wasn't. There were no significant difference in plasma FVIIa, FVII: Ag and FVIIc between CHD and control group. The IVS7 genotypic frequency in AMI group was significantly different from that in control group. There was no significant difference in genotypic frequencies and allelic frequencies in other polymphism sites. FVII: Ag was significantly higher in -402A homozygote than that in -402G homozygote. CONCLUSIONS: Increased FVII levels, especially FVIIa and FVIIc in plasma, may contribute to coronary artery thrombosis. There was significant difference in IVS7 genotype frequency between control and AMI groups, but the rest weren't significantly different. FVII: Ag was significantly higher in -402A homozygote than that in -402G homozygote. Polymorphism of -402 G/A may play an indirect role in AMI by regulating plasma FVII levels. SN - 0253-2727 UR - https://www.unboundmedicine.com/medline/citation/12482354/[Study_on_plasma_coagulation_factor_VII__FVII__levels_and_polymorphisms_of_FVII_gene_in_patients_with_coronary_heart_disease]_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -