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Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders.
J Psychiatr Res. 2003 Jan-Feb; 37(1):17-22.JP

Abstract

Previous studies have reported that fasting plasma ghrelin concentrations play an important role in the pathophysiology of eating disorders. The purpose of this study was to examine the relationship between plasma ghrelin levels and frequency of abnormal eating behaviors, nutritional parameters in eating disorders. Fasting blood samples were obtained in 40 female anorexia nervosa (AN) patients, 21 restricting type (AN-R) and 19 binge-eating/purging type (AN-BP), in 31 bulimia nervosa (BN) patients, 18 purging type (BN-P) and 13 non-purging type (BN-NP), in 15 female healthy volunteers (control) before the initiation of active treatment. The fasting plasma ghrelin concentrations in all subjects were negatively correlated with nutritional parameters such as body mass index, percent body fat and serum cholinesterase concentration. The mean plasma ghrelin level in BN-P was higher than that in both BN-NP and controls despite similar nutritional parameters. The plasma ghrelin levels in both AN-R and AN-BP did not differ from BN-P despite difference of nutritional parameters. For both AN-BP and BN-P patients with habitual binge/purge behavior, there were significant correlations among plasma ghrelin values, frequencies of binge/purge cycles and serum amylase values. In BN-NP, there were no significant correlations among plasma ghrelin values, frequencies of binge-eating episodes and serum amylase values. These results suggest that habitual binge/purge behavior may have some influence on circulating plasma ghrelin levels in both BN-P and AN-BP. Habitual binge/purge cycles with vomiting as opposed to binge-eating episodes without vomiting may have a greater influence on fasting plasma ghrelin concentration in eating disorders.

Authors+Show Affiliations

Department of Psychosomatic Medicine, Kagoshima University Hospital, Faculty of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima-City 890-8520, Kagoshima, Japan. muneki@m3.kufm.kagoshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12482466

Citation

Tanaka, Muneki, et al. "Habitual Binge/purge Behavior Influences Circulating Ghrelin Levels in Eating Disorders." Journal of Psychiatric Research, vol. 37, no. 1, 2003, pp. 17-22.
Tanaka M, Naruo T, Nagai N, et al. Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders. J Psychiatr Res. 2003;37(1):17-22.
Tanaka, M., Naruo, T., Nagai, N., Kuroki, N., Shiiya, T., Nakazato, M., Matsukura, S., & Nozoe, S. (2003). Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders. Journal of Psychiatric Research, 37(1), 17-22.
Tanaka M, et al. Habitual Binge/purge Behavior Influences Circulating Ghrelin Levels in Eating Disorders. J Psychiatr Res. 2003;37(1):17-22. PubMed PMID: 12482466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders. AU - Tanaka,Muneki, AU - Naruo,Tetsuro, AU - Nagai,Nobuatsu, AU - Kuroki,Nobutaka, AU - Shiiya,Tomomi, AU - Nakazato,Masamitsu, AU - Matsukura,Shigeru, AU - Nozoe,Shin-ichi, PY - 2002/12/17/pubmed PY - 2003/4/30/medline PY - 2002/12/17/entrez SP - 17 EP - 22 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 37 IS - 1 N2 - Previous studies have reported that fasting plasma ghrelin concentrations play an important role in the pathophysiology of eating disorders. The purpose of this study was to examine the relationship between plasma ghrelin levels and frequency of abnormal eating behaviors, nutritional parameters in eating disorders. Fasting blood samples were obtained in 40 female anorexia nervosa (AN) patients, 21 restricting type (AN-R) and 19 binge-eating/purging type (AN-BP), in 31 bulimia nervosa (BN) patients, 18 purging type (BN-P) and 13 non-purging type (BN-NP), in 15 female healthy volunteers (control) before the initiation of active treatment. The fasting plasma ghrelin concentrations in all subjects were negatively correlated with nutritional parameters such as body mass index, percent body fat and serum cholinesterase concentration. The mean plasma ghrelin level in BN-P was higher than that in both BN-NP and controls despite similar nutritional parameters. The plasma ghrelin levels in both AN-R and AN-BP did not differ from BN-P despite difference of nutritional parameters. For both AN-BP and BN-P patients with habitual binge/purge behavior, there were significant correlations among plasma ghrelin values, frequencies of binge/purge cycles and serum amylase values. In BN-NP, there were no significant correlations among plasma ghrelin values, frequencies of binge-eating episodes and serum amylase values. These results suggest that habitual binge/purge behavior may have some influence on circulating plasma ghrelin levels in both BN-P and AN-BP. Habitual binge/purge cycles with vomiting as opposed to binge-eating episodes without vomiting may have a greater influence on fasting plasma ghrelin concentration in eating disorders. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/12482466/Habitual_binge/purge_behavior_influences_circulating_ghrelin_levels_in_eating_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022395602000675 DB - PRIME DP - Unbound Medicine ER -