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Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats.
Oral Microbiol Immunol 2002; 17(6):337-43OM

Abstract

Propolis, a resinous hive product secreted by Apis mellifera bees, has been shown to reduce the incidence of dental caries in rats. Several compounds, mainly polyphenolics, have been identified in propolis. Apigenin and tt-farnesol demonstrated biological activity against mutans streptococci. We determined here their effects, alone or in combination, on glucosyltransferase activity, biofilm viability, and development of caries in rats. Sprague-Dawley rats were infected with Streptococcus sobrinus 6715 and treated topically twice daily as follows: (1) tt-farnesol, (2) apigenin, (3) vehicle control, (4) fluoride, (5) apigenin +tt-farnesol, and (6) chlorhexidine. Apigenin (1.33 mM) inhibited the activity of glucosyltransferases in solution (90-95%) and on the surface of saliva-coated hydroxyapatite beads (35-58%); it was devoid of antibacterial activity. tt-Farnesol (1.33 mM) showed modest antibacterial activity against biofilms and its effects on glucosyltransferases were minimal. The incidence of smooth-surface caries was significantly reduced by apigenin +tt-farnesol (60%), fluoride (70%), and chlorhexidine (72%) treatments compared to control (P < 0.05).

Authors+Show Affiliations

Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, NY 14642, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12485324

Citation

Koo, H, et al. "Effects of Apigenin and Tt-farnesol On Glucosyltransferase Activity, Biofilm Viability and Caries Development in Rats." Oral Microbiology and Immunology, vol. 17, no. 6, 2002, pp. 337-43.
Koo H, Pearson SK, Scott-Anne K, et al. Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. Oral Microbiol Immunol. 2002;17(6):337-43.
Koo, H., Pearson, S. K., Scott-Anne, K., Abranches, J., Cury, J. A., Rosalen, P. L., ... Bowen, W. H. (2002). Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. Oral Microbiology and Immunology, 17(6), pp. 337-43.
Koo H, et al. Effects of Apigenin and Tt-farnesol On Glucosyltransferase Activity, Biofilm Viability and Caries Development in Rats. Oral Microbiol Immunol. 2002;17(6):337-43. PubMed PMID: 12485324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. AU - Koo,H, AU - Pearson,S K, AU - Scott-Anne,K, AU - Abranches,J, AU - Cury,J A, AU - Rosalen,P L, AU - Park,Y K, AU - Marquis,R E, AU - Bowen,W H, PY - 2002/12/18/pubmed PY - 2003/3/29/medline PY - 2002/12/18/entrez SP - 337 EP - 43 JF - Oral microbiology and immunology JO - Oral Microbiol. Immunol. VL - 17 IS - 6 N2 - Propolis, a resinous hive product secreted by Apis mellifera bees, has been shown to reduce the incidence of dental caries in rats. Several compounds, mainly polyphenolics, have been identified in propolis. Apigenin and tt-farnesol demonstrated biological activity against mutans streptococci. We determined here their effects, alone or in combination, on glucosyltransferase activity, biofilm viability, and development of caries in rats. Sprague-Dawley rats were infected with Streptococcus sobrinus 6715 and treated topically twice daily as follows: (1) tt-farnesol, (2) apigenin, (3) vehicle control, (4) fluoride, (5) apigenin +tt-farnesol, and (6) chlorhexidine. Apigenin (1.33 mM) inhibited the activity of glucosyltransferases in solution (90-95%) and on the surface of saliva-coated hydroxyapatite beads (35-58%); it was devoid of antibacterial activity. tt-Farnesol (1.33 mM) showed modest antibacterial activity against biofilms and its effects on glucosyltransferases were minimal. The incidence of smooth-surface caries was significantly reduced by apigenin +tt-farnesol (60%), fluoride (70%), and chlorhexidine (72%) treatments compared to control (P < 0.05). SN - 0902-0055 UR - https://www.unboundmedicine.com/medline/citation/12485324/Effects_of_apigenin_and_tt_farnesol_on_glucosyltransferase_activity_biofilm_viability_and_caries_development_in_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0902-0055&amp;date=2002&amp;volume=17&amp;issue=6&amp;spage=337 DB - PRIME DP - Unbound Medicine ER -