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Low serum magnesium levels and metabolic syndrome.
Acta Diabetol 2002; 39(4):209-13AD

Abstract

Low serum magnesium levels are related to diabetes mellitus (DM) and high blood pressure (HBP), but as far as we know, there are no previous reports that analyzed the serum magnesium concentration in individuals with metabolic syndrome (MS). We performed a cross-sectional population-based study to compare 192 individuals with MS and 384 disorder-free control subjects, matched by age and gender. Magnesium supplementation treatment and conditions likely to provoke hypomagnesemia, including previous diagnosis of diabetes mellitus (DM) and/or high blood pressure (HBP), were exclusion criteria. In this regard, only incident cases of DM and HBP were included. MS was defined by the presence at least of two of the following features: hyperglycemia (> or =7.0 mmol/l); HBP (> or =160/90 mmHg); dyslipidemia (fasting triglycerides > or =1.7 mmol/l and/or HDL-cholesterol <1.0 mmol/l); and obesity (body mass index > or =30 kg/m(2) and/or waist-to-hip ratio > or =0.85 in women or > or =0.9 in men). Low serum magnesium levels were identified in 126 (65.6%) and 19 (4.9%) individuals with and without MS, p<0.00001. The mean serum magnesium level among subjects with MS was 1.8+/-0.3 mg/dl, and among control subjects 2.2+/-0.2 mg/dl, p<0.00001. There was a strong independent relationship between low serum magnesium levels and MS (odds ratio (OR)=6.8, CI(95%) 4.2-10.9). Among the components of MS, dyslipidemia (OR 2.8, CI(95%) 1.3-2.9) and HBP (OR 1.9, CI(95%) 1.4-2.8) were strongly related to low serum magnesium levels. This study reveals a strong relationship between decreased serum magnesium and MS.

Authors+Show Affiliations

Research Group on Diabetes and Chronic Illnesses, Medical Research Unit in Clinical Epidemiology, Mexican Social Security Institute, Durango, Mexico.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12486495

Citation

Guerrero-Romero, F, and M Rodríguez-Morán. "Low Serum Magnesium Levels and Metabolic Syndrome." Acta Diabetologica, vol. 39, no. 4, 2002, pp. 209-13.
Guerrero-Romero F, Rodríguez-Morán M. Low serum magnesium levels and metabolic syndrome. Acta Diabetol. 2002;39(4):209-13.
Guerrero-Romero, F., & Rodríguez-Morán, M. (2002). Low serum magnesium levels and metabolic syndrome. Acta Diabetologica, 39(4), pp. 209-13.
Guerrero-Romero F, Rodríguez-Morán M. Low Serum Magnesium Levels and Metabolic Syndrome. Acta Diabetol. 2002;39(4):209-13. PubMed PMID: 12486495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum magnesium levels and metabolic syndrome. AU - Guerrero-Romero,F, AU - Rodríguez-Morán,M, PY - 2002/12/18/pubmed PY - 2003/5/21/medline PY - 2002/12/18/entrez SP - 209 EP - 13 JF - Acta diabetologica JO - Acta Diabetol VL - 39 IS - 4 N2 - Low serum magnesium levels are related to diabetes mellitus (DM) and high blood pressure (HBP), but as far as we know, there are no previous reports that analyzed the serum magnesium concentration in individuals with metabolic syndrome (MS). We performed a cross-sectional population-based study to compare 192 individuals with MS and 384 disorder-free control subjects, matched by age and gender. Magnesium supplementation treatment and conditions likely to provoke hypomagnesemia, including previous diagnosis of diabetes mellitus (DM) and/or high blood pressure (HBP), were exclusion criteria. In this regard, only incident cases of DM and HBP were included. MS was defined by the presence at least of two of the following features: hyperglycemia (> or =7.0 mmol/l); HBP (> or =160/90 mmHg); dyslipidemia (fasting triglycerides > or =1.7 mmol/l and/or HDL-cholesterol <1.0 mmol/l); and obesity (body mass index > or =30 kg/m(2) and/or waist-to-hip ratio > or =0.85 in women or > or =0.9 in men). Low serum magnesium levels were identified in 126 (65.6%) and 19 (4.9%) individuals with and without MS, p<0.00001. The mean serum magnesium level among subjects with MS was 1.8+/-0.3 mg/dl, and among control subjects 2.2+/-0.2 mg/dl, p<0.00001. There was a strong independent relationship between low serum magnesium levels and MS (odds ratio (OR)=6.8, CI(95%) 4.2-10.9). Among the components of MS, dyslipidemia (OR 2.8, CI(95%) 1.3-2.9) and HBP (OR 1.9, CI(95%) 1.4-2.8) were strongly related to low serum magnesium levels. This study reveals a strong relationship between decreased serum magnesium and MS. SN - 0940-5429 UR - https://www.unboundmedicine.com/medline/citation/12486495/Low_serum_magnesium_levels_and_metabolic_syndrome_ L2 - https://dx.doi.org/10.1007/s005920200036 DB - PRIME DP - Unbound Medicine ER -