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Viral respiratory infections in association with asthma and sinusitis: a review.
Ann Allergy Asthma Immunol. 2002 Dec; 89(6):553-60.AA

Abstract

OBJECTIVE

Viral respiratory infections (VRIs) commonly precede asthma exacerbations in both children and adults. Likewise, VRIs may affect the paranasal sinuses, predisposing infected individuals to the development of subsequent acute bacterial sinusitis. This article discusses the role that viruses play in both the development of asthma and in acute asthma exacerbations. Mechanisms by which viral infections provoke asthma exacerbations are reviewed, and treatment of such episodes is discussed. The pathogenesis of sinusitis and association with VRIs is reviewed along with treatment recommendations.

DATA SOURCES

Relevant articles in the medical literature were reviewed with sources including randomized, controlled clinical trials, review articles, epidemiologic studies, and standard textbooks in allergy and immunology.

CONCLUSIONS

This review highlights the prominent role that viral pathogens (especially rhinovirus) play in exacerbation of asthma and in the development of sinus disease. The specific mechanisms whereby viral infection leads to an acute asthma exacerbation or to subsequent bacterial sinusitis are described. Treatment options are outlined including the potential future application of antiviral compounds.

Authors+Show Affiliations

Albany Medical College. Albany, New York, USA. brassmicroscope@msn.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12487219

Citation

Osur, Scott L.. "Viral Respiratory Infections in Association With Asthma and Sinusitis: a Review." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 89, no. 6, 2002, pp. 553-60.
Osur SL. Viral respiratory infections in association with asthma and sinusitis: a review. Ann Allergy Asthma Immunol. 2002;89(6):553-60.
Osur, S. L. (2002). Viral respiratory infections in association with asthma and sinusitis: a review. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 89(6), 553-60.
Osur SL. Viral Respiratory Infections in Association With Asthma and Sinusitis: a Review. Ann Allergy Asthma Immunol. 2002;89(6):553-60. PubMed PMID: 12487219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Viral respiratory infections in association with asthma and sinusitis: a review. A1 - Osur,Scott L, PY - 2002/12/19/pubmed PY - 2003/1/8/medline PY - 2002/12/19/entrez SP - 553 EP - 60 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 89 IS - 6 N2 - OBJECTIVE: Viral respiratory infections (VRIs) commonly precede asthma exacerbations in both children and adults. Likewise, VRIs may affect the paranasal sinuses, predisposing infected individuals to the development of subsequent acute bacterial sinusitis. This article discusses the role that viruses play in both the development of asthma and in acute asthma exacerbations. Mechanisms by which viral infections provoke asthma exacerbations are reviewed, and treatment of such episodes is discussed. The pathogenesis of sinusitis and association with VRIs is reviewed along with treatment recommendations. DATA SOURCES: Relevant articles in the medical literature were reviewed with sources including randomized, controlled clinical trials, review articles, epidemiologic studies, and standard textbooks in allergy and immunology. CONCLUSIONS: This review highlights the prominent role that viral pathogens (especially rhinovirus) play in exacerbation of asthma and in the development of sinus disease. The specific mechanisms whereby viral infection leads to an acute asthma exacerbation or to subsequent bacterial sinusitis are described. Treatment options are outlined including the potential future application of antiviral compounds. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/12487219/Viral_respiratory_infections_in_association_with_asthma_and_sinusitis:_a_review_ DB - PRIME DP - Unbound Medicine ER -