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Fibre intake and laryngeal cancer risk.
Ann Oncol. 2003 Jan; 14(1):162-7.AO

Abstract

BACKGROUND

Consumption of vegetables, fruit and whole grain cereals has been inversely related to laryngeal cancer risk. Among the potential protective agents found in these foods, information on dietary fibres and laryngeal cancer risk are scanty.

PATIENTS AND METHODS

A multi-centric, hospital-based case-control study was conducted on 527 patients with squamous-cell carcinoma of the larynx and 1,297 non-neoplastic controls. Cases and controls, frequency matched by age, sex and study centre, were interviewed using a validated food frequency questionnaire.

RESULTS

Compared with the lowest quintile of fibre intake, the odds ratios (ORs) for the highest quintile were 0.3 [95% confidence interval (CI) 0.2-0.4] for total fibre, 0.3 (95% CI 0.2-0.5) for soluble non-cellulose polysaccharides (NCP) and for total insoluble fibre, including cellulose (OR = 0.3, 95% CI 0.2-0.4) and insoluble NCP (OR = 0.4, 95% CI 0.3-0.7). The ORs were 0.2 (95% CI 0.1-0.4) for fibre from vegetables, 0.5 (95% CI 0.3-0.7) from fruit and 1.1 (95% CI 0.6-1.9) from grains. The inverse association observed was similar among different subsites of laryngeal cancer, and consistent across strata of various covariates.

CONCLUSIONS

This study found a strong inverse association between fibre intake and laryngeal cancer risk, which points to fibre as one of the beneficial components of vegetables and fruit.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. pelucchi@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12488309

Citation

Pelucchi, C, et al. "Fibre Intake and Laryngeal Cancer Risk." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 14, no. 1, 2003, pp. 162-7.
Pelucchi C, Talamini R, Levi F, et al. Fibre intake and laryngeal cancer risk. Ann Oncol. 2003;14(1):162-7.
Pelucchi, C., Talamini, R., Levi, F., Bosetti, C., La Vecchia, C., Negri, E., Parpinel, M., & Franceschi, S. (2003). Fibre intake and laryngeal cancer risk. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 14(1), 162-7.
Pelucchi C, et al. Fibre Intake and Laryngeal Cancer Risk. Ann Oncol. 2003;14(1):162-7. PubMed PMID: 12488309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibre intake and laryngeal cancer risk. AU - Pelucchi,C, AU - Talamini,R, AU - Levi,F, AU - Bosetti,C, AU - La Vecchia,C, AU - Negri,E, AU - Parpinel,M, AU - Franceschi,S, PY - 2002/12/19/pubmed PY - 2003/5/24/medline PY - 2002/12/19/entrez SP - 162 EP - 7 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 14 IS - 1 N2 - BACKGROUND: Consumption of vegetables, fruit and whole grain cereals has been inversely related to laryngeal cancer risk. Among the potential protective agents found in these foods, information on dietary fibres and laryngeal cancer risk are scanty. PATIENTS AND METHODS: A multi-centric, hospital-based case-control study was conducted on 527 patients with squamous-cell carcinoma of the larynx and 1,297 non-neoplastic controls. Cases and controls, frequency matched by age, sex and study centre, were interviewed using a validated food frequency questionnaire. RESULTS: Compared with the lowest quintile of fibre intake, the odds ratios (ORs) for the highest quintile were 0.3 [95% confidence interval (CI) 0.2-0.4] for total fibre, 0.3 (95% CI 0.2-0.5) for soluble non-cellulose polysaccharides (NCP) and for total insoluble fibre, including cellulose (OR = 0.3, 95% CI 0.2-0.4) and insoluble NCP (OR = 0.4, 95% CI 0.3-0.7). The ORs were 0.2 (95% CI 0.1-0.4) for fibre from vegetables, 0.5 (95% CI 0.3-0.7) from fruit and 1.1 (95% CI 0.6-1.9) from grains. The inverse association observed was similar among different subsites of laryngeal cancer, and consistent across strata of various covariates. CONCLUSIONS: This study found a strong inverse association between fibre intake and laryngeal cancer risk, which points to fibre as one of the beneficial components of vegetables and fruit. SN - 0923-7534 UR - https://www.unboundmedicine.com/medline/citation/12488309/Fibre_intake_and_laryngeal_cancer_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0923-7534(19)63922-0 DB - PRIME DP - Unbound Medicine ER -