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A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia.

Abstract

Plant sterols, soy proteins, and viscous fibers are advised for cholesterol reduction but their combined effect has never been tested. We therefore assessed their combined effect on blood lipids in hyperlipidemic subjects who were already consuming a low-saturated fat, low-cholesterol diet before starting the study. The test (combination) diet was 1 month in duration and was very low in saturated fat and high in plant sterols (1 g/1,000 kcal), soy protein (23 g/1,000 kcal), and viscous fibers (9 g/1,000 kcal) obtained from foods available in supermarkets and health food stores. One subject also completed 2 further diet periods: a low-fat control diet and a control diet plus 20 mg/d lovastatin. Fasting blood lipids, blood pressure, and body weight were measured prior to and at weekly intervals during the study. The combination diet was rated as acceptable and very filling. The diet reduced low-density lipoprotein (LDL)-cholesterol by 29.0% +/- 2.7% (P <.001) and the ratio of LDL-cholesterol to high-density lipoprotein (HDL)-cholesterol by 26.5% +/- 3.4% (P <.001). Near maximal reductions were seen by week 2. In the subject who took Mevacor and control diets each for 4 weeks, the reduction in LDL:HDL-cholesterol on Mevacor was similar to the combination diet. We conclude that acceptable diets of foods from supermarkets and health food stores that contain recognized cholesterol-lowering dietary components in combination (a dietary portfolio) may be as effective as the starting dose of older first-line drugs in managing hypercholesterolemia.

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  • Authors+Show Affiliations

    ,

    Clinical Nutrition and Risk Factor Modification Center, Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada.

    , , , , , , , , , ,

    Source

    Metabolism: clinical and experimental 51:12 2002 Dec pg 1596-604

    MeSH

    Adult
    Aged
    Aged, 80 and over
    C-Reactive Protein
    Cholesterol
    Diet
    Dietary Fiber
    Female
    Humans
    Hypercholesterolemia
    Lipids
    Lipoproteins, LDL
    Male
    Middle Aged
    Phytosterols
    Plant Proteins, Dietary
    Viscosity

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12489074

    Citation

    Jenkins, David J A., et al. "A Dietary Portfolio Approach to Cholesterol Reduction: Combined Effects of Plant Sterols, Vegetable Proteins, and Viscous Fibers in Hypercholesterolemia." Metabolism: Clinical and Experimental, vol. 51, no. 12, 2002, pp. 1596-604.
    Jenkins DJ, Kendall CW, Faulkner D, et al. A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metab Clin Exp. 2002;51(12):1596-604.
    Jenkins, D. J., Kendall, C. W., Faulkner, D., Vidgen, E., Trautwein, E. A., Parker, T. L., ... Connelly, P. W. (2002). A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism: Clinical and Experimental, 51(12), pp. 1596-604.
    Jenkins DJ, et al. A Dietary Portfolio Approach to Cholesterol Reduction: Combined Effects of Plant Sterols, Vegetable Proteins, and Viscous Fibers in Hypercholesterolemia. Metab Clin Exp. 2002;51(12):1596-604. PubMed PMID: 12489074.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. AU - Jenkins,David J A, AU - Kendall,Cyril W C, AU - Faulkner,Dorothea, AU - Vidgen,Edward, AU - Trautwein,Elke A, AU - Parker,Tina L, AU - Marchie,Augustine, AU - Koumbridis,George, AU - Lapsley,Karen G, AU - Josse,Robert G, AU - Leiter,Lawrence A, AU - Connelly,Philip W, PY - 2002/12/19/pubmed PY - 2003/1/14/medline PY - 2002/12/19/entrez SP - 1596 EP - 604 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 51 IS - 12 N2 - Plant sterols, soy proteins, and viscous fibers are advised for cholesterol reduction but their combined effect has never been tested. We therefore assessed their combined effect on blood lipids in hyperlipidemic subjects who were already consuming a low-saturated fat, low-cholesterol diet before starting the study. The test (combination) diet was 1 month in duration and was very low in saturated fat and high in plant sterols (1 g/1,000 kcal), soy protein (23 g/1,000 kcal), and viscous fibers (9 g/1,000 kcal) obtained from foods available in supermarkets and health food stores. One subject also completed 2 further diet periods: a low-fat control diet and a control diet plus 20 mg/d lovastatin. Fasting blood lipids, blood pressure, and body weight were measured prior to and at weekly intervals during the study. The combination diet was rated as acceptable and very filling. The diet reduced low-density lipoprotein (LDL)-cholesterol by 29.0% +/- 2.7% (P <.001) and the ratio of LDL-cholesterol to high-density lipoprotein (HDL)-cholesterol by 26.5% +/- 3.4% (P <.001). Near maximal reductions were seen by week 2. In the subject who took Mevacor and control diets each for 4 weeks, the reduction in LDL:HDL-cholesterol on Mevacor was similar to the combination diet. We conclude that acceptable diets of foods from supermarkets and health food stores that contain recognized cholesterol-lowering dietary components in combination (a dietary portfolio) may be as effective as the starting dose of older first-line drugs in managing hypercholesterolemia. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/12489074/A_dietary_portfolio_approach_to_cholesterol_reduction:_combined_effects_of_plant_sterols_vegetable_proteins_and_viscous_fibers_in_hypercholesterolemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S002604950200166X DB - PRIME DP - Unbound Medicine ER -