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Acyclovir for the treatment and prevention of recurrent infectious herpes simplex keratitis.
Chin Med J (Engl) 2002; 115(10):1569-72CM

Abstract

OBJECTIVE

To evaluate the role of acyclovir in treatment and prevention of herpes simplex keratitis (HSK).

METHODS

A total of 105 patients with HSK were divided into 4 groups. Group 1 consisted of 79 patients with HSV epithelial keratitis. Group 2 consisted of 20 patients with interstitial keratitis. Group 3 consisted of 6 patients with necrotizing keratitis. Group 4 consisted of 4 necrotizing keratitis patients with corneal perforation treated with conjunctival flap and corneal transplantation. All patients were treated with acyclovir systemically and topically. After full recovery, the patients with epithelial HSK and stromal HSK were randomly divided into two groups individually. One group was constantly treated with oral acyclovir at 300 mg/day for 1 year as a prophylaxis group. The other group was designated as control.

RESULTS

During the one-year treatment and follow-up, 5 cases with epithelial HSK recurred in the prophylaxis group and 14 cases in the control group, showing a statistically significant difference. One case of stromal HSK recurred in the prophylaxis group and 4 recurred in the control group.

CONCLUSION

Long term and low dose oral acyclovir for prophylaxis of recurrent epithelial herpes simplex infection and therapeutic doses of oral acyclovir reduce both the rate and duration of recurrences of infectious herpes simplex keratitis.

Authors+Show Affiliations

Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan 250012, China. xywu@public.jn.sd.cnNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12490113

Citation

Wu, Xinyi, and Xuan Chen. "Acyclovir for the Treatment and Prevention of Recurrent Infectious Herpes Simplex Keratitis." Chinese Medical Journal, vol. 115, no. 10, 2002, pp. 1569-72.
Wu X, Chen X. Acyclovir for the treatment and prevention of recurrent infectious herpes simplex keratitis. Chin Med J. 2002;115(10):1569-72.
Wu, X., & Chen, X. (2002). Acyclovir for the treatment and prevention of recurrent infectious herpes simplex keratitis. Chinese Medical Journal, 115(10), pp. 1569-72.
Wu X, Chen X. Acyclovir for the Treatment and Prevention of Recurrent Infectious Herpes Simplex Keratitis. Chin Med J. 2002;115(10):1569-72. PubMed PMID: 12490113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acyclovir for the treatment and prevention of recurrent infectious herpes simplex keratitis. AU - Wu,Xinyi, AU - Chen,Xuan, PY - 2002/12/20/pubmed PY - 2003/1/29/medline PY - 2002/12/20/entrez SP - 1569 EP - 72 JF - Chinese medical journal JO - Chin. Med. J. VL - 115 IS - 10 N2 - OBJECTIVE: To evaluate the role of acyclovir in treatment and prevention of herpes simplex keratitis (HSK). METHODS: A total of 105 patients with HSK were divided into 4 groups. Group 1 consisted of 79 patients with HSV epithelial keratitis. Group 2 consisted of 20 patients with interstitial keratitis. Group 3 consisted of 6 patients with necrotizing keratitis. Group 4 consisted of 4 necrotizing keratitis patients with corneal perforation treated with conjunctival flap and corneal transplantation. All patients were treated with acyclovir systemically and topically. After full recovery, the patients with epithelial HSK and stromal HSK were randomly divided into two groups individually. One group was constantly treated with oral acyclovir at 300 mg/day for 1 year as a prophylaxis group. The other group was designated as control. RESULTS: During the one-year treatment and follow-up, 5 cases with epithelial HSK recurred in the prophylaxis group and 14 cases in the control group, showing a statistically significant difference. One case of stromal HSK recurred in the prophylaxis group and 4 recurred in the control group. CONCLUSION: Long term and low dose oral acyclovir for prophylaxis of recurrent epithelial herpes simplex infection and therapeutic doses of oral acyclovir reduce both the rate and duration of recurrences of infectious herpes simplex keratitis. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/12490113/Acyclovir_for_the_treatment_and_prevention_of_recurrent_infectious_herpes_simplex_keratitis_ DB - PRIME DP - Unbound Medicine ER -