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Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35.
Cancer. 2003 Jan 01; 97(1):134-47.C

Abstract

BACKGROUND

The age specific breast cancer incidence rate for African-American women under age 35 is more than twice the rate for white women of similar age, and the mortality rate is more than three times higher. To determine factors that may explain racial/ethnic variation in outcomes among young women diagnosed with breast cancer, the authors examined the clinical presentation, treatment, and survival of African-American, Hispanic, and white women under age 35 years.

METHODS

Surveillance, Epidemiology, and End Results (SEER) Program data for 1990-1998 and SEER Patterns of Care data for 1990, 1991, and 1995 were used for this analysis. Multivariate logistic regression analyses were performed to examine factors associated with the receipt of selected breast cancer treatments. Kaplan-Meier survival analyses and Cox proportional hazards regression analyses were used to examine 5-year overall survival and disease-specific survival.

RESULTS

The authors found racial/ethnic variation in clinical presentation, treatment, and survival. Both African-American and Hispanic women presented with higher disease stage and a higher prevalence of adverse prognostic indicators compared to white women. African-American and Hispanic women received cancer-directed surgery and radiation less frequently after undergoing breast-conserving surgery. Racial/ethnic differences in clinical presentation and treatment were associated with poorer overall survival in unadjusted analyses. African-American and Hispanic women also had poorer overall survival after controlling for clinical and demographic characteristics and type of treatment.

CONCLUSIONS

Future research studies should further examine the factors that influence racial/ethnic differences in incidence, clinical presentation, and treatment differentials among young women diagnosed with breast cancer. A better understanding of these factors will facilitate the development of strategies to help eliminate this health disparity.

Authors+Show Affiliations

Applied Research Program, Health Service and Economics Branch, Division of Cancer Control and Population Science, National Cancer Institute, 6130 Executive Boulevard, MSC 7344, EPN Room 4005, Bethesda, MD 20892-7344, USA. shaversv@mail.nih.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12491515

Citation

Shavers, Vickie L., et al. "Racial/ethnic Variation in Clinical Presentation, Treatment, and Survival Among Breast Cancer Patients Under Age 35." Cancer, vol. 97, no. 1, 2003, pp. 134-47.
Shavers VL, Harlan LC, Stevens JL. Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. Cancer. 2003;97(1):134-47.
Shavers, V. L., Harlan, L. C., & Stevens, J. L. (2003). Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. Cancer, 97(1), 134-47.
Shavers VL, Harlan LC, Stevens JL. Racial/ethnic Variation in Clinical Presentation, Treatment, and Survival Among Breast Cancer Patients Under Age 35. Cancer. 2003 Jan 1;97(1):134-47. PubMed PMID: 12491515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. AU - Shavers,Vickie L, AU - Harlan,Linda C, AU - Stevens,Jennifer L, PY - 2002/12/20/pubmed PY - 2003/1/25/medline PY - 2002/12/20/entrez SP - 134 EP - 47 JF - Cancer JO - Cancer VL - 97 IS - 1 N2 - BACKGROUND: The age specific breast cancer incidence rate for African-American women under age 35 is more than twice the rate for white women of similar age, and the mortality rate is more than three times higher. To determine factors that may explain racial/ethnic variation in outcomes among young women diagnosed with breast cancer, the authors examined the clinical presentation, treatment, and survival of African-American, Hispanic, and white women under age 35 years. METHODS: Surveillance, Epidemiology, and End Results (SEER) Program data for 1990-1998 and SEER Patterns of Care data for 1990, 1991, and 1995 were used for this analysis. Multivariate logistic regression analyses were performed to examine factors associated with the receipt of selected breast cancer treatments. Kaplan-Meier survival analyses and Cox proportional hazards regression analyses were used to examine 5-year overall survival and disease-specific survival. RESULTS: The authors found racial/ethnic variation in clinical presentation, treatment, and survival. Both African-American and Hispanic women presented with higher disease stage and a higher prevalence of adverse prognostic indicators compared to white women. African-American and Hispanic women received cancer-directed surgery and radiation less frequently after undergoing breast-conserving surgery. Racial/ethnic differences in clinical presentation and treatment were associated with poorer overall survival in unadjusted analyses. African-American and Hispanic women also had poorer overall survival after controlling for clinical and demographic characteristics and type of treatment. CONCLUSIONS: Future research studies should further examine the factors that influence racial/ethnic differences in incidence, clinical presentation, and treatment differentials among young women diagnosed with breast cancer. A better understanding of these factors will facilitate the development of strategies to help eliminate this health disparity. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/12491515/Racial/ethnic_variation_in_clinical_presentation_treatment_and_survival_among_breast_cancer_patients_under_age_35_ L2 - https://doi.org/10.1002/cncr.11051 DB - PRIME DP - Unbound Medicine ER -