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Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects.
J Psychiatry Neurosci 2002; 27(6):429-37JP

Abstract

OBJECTIVE

To examine the effects of short-term valproate treatment on human brain serotonin and dopamine function by means of challenge tests with ipsapirone, a partial agonist at 5-HT1A receptors, and apomorphine, a dopamine receptor agonist.

DESIGN

Experimental challenge-rechallenge, within-subjects repeated measures, before and at the end of 14 days of treatment with valproate at a dosage of 625 mg/d (reached gradually over the first 5 days).

PARTICIPANTS

Eight healthy male volunteers (mean age 38 years) selected for good physical and mental health who were nonsmokers.

OUTCOME MEASURES

Pharmacological probes were used to evaluate the effects of valproate. In the ipsapirone challenge, changes in adrenocorticotropic hormone (ACTH), cortisol and body temperature were measured, and in the apomorphine challenge, growth hormone (GH) and prolactin were the dependent variables.

RESULTS

Valproate treatment did not significantly alter the ACTH, cortisol or body temperature responses to ipsapirone (20 mg by mouth), which reached equivalent plasma levels at each challenge. Similarly, valproate treatment did not alter the GH or prolactin responses to apomorphine (5 micrograms/kg subcutaneously).

CONCLUSIONS

These results suggest that short-term treatment with valproate at a dose of 625 mg/d does not alter hypothalamic or pituitary 5-HT1A or dopamine receptor responses to challenges with ipsapirone and apomorphine, respectively.

Authors+Show Affiliations

Departments of Psychiatry and Physiology, Queen's University, Providence Continuing Care Centre, Mental Health Services, Kingston, ON. DelvaN@pccc.health.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12491576

Citation

Delva, Nicholas J., et al. "Effects of Short-term Administration of Valproate On serotonin-1A and Dopamine Receptor Function in Healthy Human Subjects." Journal of Psychiatry & Neuroscience : JPN, vol. 27, no. 6, 2002, pp. 429-37.
Delva NJ, Brooks DL, Franklin M, et al. Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects. J Psychiatry Neurosci. 2002;27(6):429-37.
Delva, N. J., Brooks, D. L., Franklin, M., al-Said, K., Hawken, E. R., Merali, Z., ... Ravindran, A. V. (2002). Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects. Journal of Psychiatry & Neuroscience : JPN, 27(6), pp. 429-37.
Delva NJ, et al. Effects of Short-term Administration of Valproate On serotonin-1A and Dopamine Receptor Function in Healthy Human Subjects. J Psychiatry Neurosci. 2002;27(6):429-37. PubMed PMID: 12491576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects. AU - Delva,Nicholas J, AU - Brooks,Deborah L, AU - Franklin,Michael, AU - al-Said,Khalid, AU - Hawken,Emily R, AU - Merali,Zul, AU - Lawson,J Stuart, AU - Ravindran,Arun V, PY - 2002/12/21/pubmed PY - 2003/2/13/medline PY - 2002/12/21/entrez SP - 429 EP - 37 JF - Journal of psychiatry & neuroscience : JPN JO - J Psychiatry Neurosci VL - 27 IS - 6 N2 - OBJECTIVE: To examine the effects of short-term valproate treatment on human brain serotonin and dopamine function by means of challenge tests with ipsapirone, a partial agonist at 5-HT1A receptors, and apomorphine, a dopamine receptor agonist. DESIGN: Experimental challenge-rechallenge, within-subjects repeated measures, before and at the end of 14 days of treatment with valproate at a dosage of 625 mg/d (reached gradually over the first 5 days). PARTICIPANTS: Eight healthy male volunteers (mean age 38 years) selected for good physical and mental health who were nonsmokers. OUTCOME MEASURES: Pharmacological probes were used to evaluate the effects of valproate. In the ipsapirone challenge, changes in adrenocorticotropic hormone (ACTH), cortisol and body temperature were measured, and in the apomorphine challenge, growth hormone (GH) and prolactin were the dependent variables. RESULTS: Valproate treatment did not significantly alter the ACTH, cortisol or body temperature responses to ipsapirone (20 mg by mouth), which reached equivalent plasma levels at each challenge. Similarly, valproate treatment did not alter the GH or prolactin responses to apomorphine (5 micrograms/kg subcutaneously). CONCLUSIONS: These results suggest that short-term treatment with valproate at a dose of 625 mg/d does not alter hypothalamic or pituitary 5-HT1A or dopamine receptor responses to challenges with ipsapirone and apomorphine, respectively. SN - 1180-4882 UR - https://www.unboundmedicine.com/medline/citation/12491576/Effects_of_short_term_administration_of_valproate_on_serotonin_1A_and_dopamine_receptor_function_in_healthy_human_subjects_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12491576.ui DB - PRIME DP - Unbound Medicine ER -