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Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus.
Histopathology. 2003 Jan; 42(1):61-5.H

Abstract

AIM

To report a rare case of oesophageal Paget's disease and its rarer combination with submucosal gland carcinoma of the lower oesophagus.

METHODS AND RESULTS

A 74-year-old Saudi female was admitted with the complaint of dysphagia. Endoscopic examination showed an ulcerated tumour at the gastro-oesophageal junction. Initial biopsy showed an undifferentiated carcinoma with pagetoid spread in the oesophageal stratified squamous epithelium. Oesophago-gastrectomy specimen showed a lobulated, poorly differentiated mucous gland carcinoma at the gastro-oesophageal junction. The tumour showed focal acinar differentiation and obvious cancerization of the submucosal glands, somewhat similar to the breast lobular carcinoma in situ. One of the isolated and cancerized submucosal glands also showed carcinoma in situ of its duct. Oesophageal surface epithelium showed extensive pagetoid spread, both over and away from the main tumour. The pagetoid tumour cells showed selective positivity for cytokeratin 7, cytokeratin Cam 5.2, BerEP4 and to a lesser extent for CEA.

CONCLUSIONS

As far as we know, this is the fifth case report of oesophageal Paget's disease and the first report of its association with the underlying mucous gland carcinoma.

Authors+Show Affiliations

Division of Histopathology, Department of Pathology, Armed Forces Hospital Riyadh, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12493026

Citation

Haleem, A, et al. "Paget's Disease of the Oesophagus Associated With Mucous Gland Carcinoma of the Lower Oesophagus." Histopathology, vol. 42, no. 1, 2003, pp. 61-5.
Haleem A, Kfoury H, Al Juboury M, et al. Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus. Histopathology. 2003;42(1):61-5.
Haleem, A., Kfoury, H., Al Juboury, M., & Al Husseini, H. (2003). Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus. Histopathology, 42(1), 61-5.
Haleem A, et al. Paget's Disease of the Oesophagus Associated With Mucous Gland Carcinoma of the Lower Oesophagus. Histopathology. 2003;42(1):61-5. PubMed PMID: 12493026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus. AU - Haleem,A, AU - Kfoury,H, AU - Al Juboury,M, AU - Al Husseini,H, PY - 2002/12/21/pubmed PY - 2003/6/12/medline PY - 2002/12/21/entrez SP - 61 EP - 5 JF - Histopathology JO - Histopathology VL - 42 IS - 1 N2 - AIM: To report a rare case of oesophageal Paget's disease and its rarer combination with submucosal gland carcinoma of the lower oesophagus. METHODS AND RESULTS: A 74-year-old Saudi female was admitted with the complaint of dysphagia. Endoscopic examination showed an ulcerated tumour at the gastro-oesophageal junction. Initial biopsy showed an undifferentiated carcinoma with pagetoid spread in the oesophageal stratified squamous epithelium. Oesophago-gastrectomy specimen showed a lobulated, poorly differentiated mucous gland carcinoma at the gastro-oesophageal junction. The tumour showed focal acinar differentiation and obvious cancerization of the submucosal glands, somewhat similar to the breast lobular carcinoma in situ. One of the isolated and cancerized submucosal glands also showed carcinoma in situ of its duct. Oesophageal surface epithelium showed extensive pagetoid spread, both over and away from the main tumour. The pagetoid tumour cells showed selective positivity for cytokeratin 7, cytokeratin Cam 5.2, BerEP4 and to a lesser extent for CEA. CONCLUSIONS: As far as we know, this is the fifth case report of oesophageal Paget's disease and the first report of its association with the underlying mucous gland carcinoma. SN - 0309-0167 UR - https://www.unboundmedicine.com/medline/citation/12493026/Paget's_disease_of_the_oesophagus_associated_with_mucous_gland_carcinoma_of_the_lower_oesophagus_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0309-0167&date=2003&volume=42&issue=1&spage=61 DB - PRIME DP - Unbound Medicine ER -