Tags

Type your tag names separated by a space and hit enter

Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women.
Br J Nutr. 2002 Dec; 88(6):635-40.BJ

Abstract

Postprandial plasma insulin concentrations after a single high-fat meal may be modified by the presence of specific fatty acids although the effects of sequential meal ingestion are unknown. The aim of the present study was to examine the effects of altering the fatty acid composition in a single mixed fat-carbohydrate meal on glucose metabolism and insulin sensitivity of a second meal eaten 5 h later. Insulin sensitivity was assessed using a minimal model approach. Ten healthy post-menopausal women underwent four two-meal studies in random order. A high-fat breakfast (40 g fat) where the fatty acid composition was predominantly saturated fatty acids (SFA), n-6 polyunsaturated fatty acids (PUFA), long-chain n-3 PUFA or monounsaturated fatty acids (MUFA) was followed 5 h later by a low-fat, high-carbohydrate lunch (5.7 g fat), which was identical in all four studies. The plasma insulin response was significantly higher following the SFA meal than the other meals after both breakfast and lunch (P<0.006) although there was no effect of breakfast fatty acid composition on plasma glucose concentrations. Postprandial insulin sensitivity (SI(Oral)) was assessed for 180 min after each meal. SI(Oral) was significantly lower after lunch than after breakfast for all four test meals (P=0.019) following the same rank order (SFA < n-6 PUFA < n-3 PUFA < MUFA) for each meal. The present study demonstrates that a single meal rich in SFA reduces postprandial insulin sensitivity with 'carry-over' effects for the next meal.

Authors+Show Affiliations

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX2 6HE. denise.robertson@oxlip.ox.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12493085

Citation

Robertson, M D., et al. "Acute Effects of Meal Fatty Acid Composition On Insulin Sensitivity in Healthy Post-menopausal Women." The British Journal of Nutrition, vol. 88, no. 6, 2002, pp. 635-40.
Robertson MD, Jackson KG, Fielding BA, et al. Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women. Br J Nutr. 2002;88(6):635-40.
Robertson, M. D., Jackson, K. G., Fielding, B. A., Williams, C. M., & Frayn, K. N. (2002). Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women. The British Journal of Nutrition, 88(6), 635-40.
Robertson MD, et al. Acute Effects of Meal Fatty Acid Composition On Insulin Sensitivity in Healthy Post-menopausal Women. Br J Nutr. 2002;88(6):635-40. PubMed PMID: 12493085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women. AU - Robertson,M D, AU - Jackson,K G, AU - Fielding,B A, AU - Williams,C M, AU - Frayn,K N, PY - 2002/12/21/pubmed PY - 2003/1/29/medline PY - 2002/12/21/entrez SP - 635 EP - 40 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 88 IS - 6 N2 - Postprandial plasma insulin concentrations after a single high-fat meal may be modified by the presence of specific fatty acids although the effects of sequential meal ingestion are unknown. The aim of the present study was to examine the effects of altering the fatty acid composition in a single mixed fat-carbohydrate meal on glucose metabolism and insulin sensitivity of a second meal eaten 5 h later. Insulin sensitivity was assessed using a minimal model approach. Ten healthy post-menopausal women underwent four two-meal studies in random order. A high-fat breakfast (40 g fat) where the fatty acid composition was predominantly saturated fatty acids (SFA), n-6 polyunsaturated fatty acids (PUFA), long-chain n-3 PUFA or monounsaturated fatty acids (MUFA) was followed 5 h later by a low-fat, high-carbohydrate lunch (5.7 g fat), which was identical in all four studies. The plasma insulin response was significantly higher following the SFA meal than the other meals after both breakfast and lunch (P<0.006) although there was no effect of breakfast fatty acid composition on plasma glucose concentrations. Postprandial insulin sensitivity (SI(Oral)) was assessed for 180 min after each meal. SI(Oral) was significantly lower after lunch than after breakfast for all four test meals (P=0.019) following the same rank order (SFA < n-6 PUFA < n-3 PUFA < MUFA) for each meal. The present study demonstrates that a single meal rich in SFA reduces postprandial insulin sensitivity with 'carry-over' effects for the next meal. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/12493085/Acute_effects_of_meal_fatty_acid_composition_on_insulin_sensitivity_in_healthy_post_menopausal_women_ L2 - https://www.cambridge.org/core/product/identifier/S0007114502002386/type/journal_article DB - PRIME DP - Unbound Medicine ER -