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Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
Planta Med. 2002 Dec; 68(12):1055-8.PM

Abstract

Inhibitors of cytochrome P450 3A4 (CYP3A4) were identified in crude extracts from the rhizomes of Piper methysticum G. Forst. (Kava-Kava) using bioassay-guided fractionation. After preliminary purification of an ethyl acetate extract with solid phase extraction, the eluate was further fractionated by means of HPLC and fractions were tested for inhibitory potency using cDNA expressed CYP3A4. Positive fractions were analysed with LC/MS using electrospray ionisation and kavapyrones could be identified as the main CYP3A4 inhibitory components of Piper methysticum.

Authors+Show Affiliations

Institute of Pharmacy and Food Chemistry, Julius-Maximilians-University, Würzburg, Germany. m.unger@pharmazie.uni-wuerzburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12494328

Citation

Unger, Matthias, et al. "Inhibition of Cytochrome P450 3A4 By Extracts and Kavalactones of Piper Methysticum (Kava-Kava)." Planta Medica, vol. 68, no. 12, 2002, pp. 1055-8.
Unger M, Holzgrabe U, Jacobsen W, et al. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Med. 2002;68(12):1055-8.
Unger, M., Holzgrabe, U., Jacobsen, W., Cummins, C., & Benet, L. Z. (2002). Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Medica, 68(12), 1055-8.
Unger M, et al. Inhibition of Cytochrome P450 3A4 By Extracts and Kavalactones of Piper Methysticum (Kava-Kava). Planta Med. 2002;68(12):1055-8. PubMed PMID: 12494328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). AU - Unger,Matthias, AU - Holzgrabe,Ulrike, AU - Jacobsen,Wolfgang, AU - Cummins,Carolyn, AU - Benet,Leslie Z, PY - 2002/12/21/pubmed PY - 2003/3/19/medline PY - 2002/12/21/entrez SP - 1055 EP - 8 JF - Planta medica JO - Planta Med VL - 68 IS - 12 N2 - Inhibitors of cytochrome P450 3A4 (CYP3A4) were identified in crude extracts from the rhizomes of Piper methysticum G. Forst. (Kava-Kava) using bioassay-guided fractionation. After preliminary purification of an ethyl acetate extract with solid phase extraction, the eluate was further fractionated by means of HPLC and fractions were tested for inhibitory potency using cDNA expressed CYP3A4. Positive fractions were analysed with LC/MS using electrospray ionisation and kavapyrones could be identified as the main CYP3A4 inhibitory components of Piper methysticum. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/12494328/Inhibition_of_cytochrome_P450_3A4_by_extracts_and_kavalactones_of_Piper_methysticum__Kava_Kava__ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-36360 DB - PRIME DP - Unbound Medicine ER -