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Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa.
Planta Med. 2002 Dec; 68(12):1131-3.PM

Abstract

From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4 Z,7 Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6 Z,9 Z)-6,9-pentadecadienyl]-4(1 H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 microM (1), 23.8 microM (2), 20.1 microM (3) and 13.5 mu (4).

Authors+Show Affiliations

Ko JS
Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea.
Rho MC
No affiliation info available
Chung MY
No affiliation info available
Song HY
No affiliation info available
Kang JS
No affiliation info available
Kim K
No affiliation info available
Lee HS
No affiliation info available
Kim YK
No affiliation info available

MeSH

AcyltransferasesAlkaloidsAnimalsDiacylglycerol O-AcyltransferaseEvodiaFruitMaleMicrosomes, LiverMolecular StructurePlant ExtractsQuinolonesRatsRats, Sprague-Dawley

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12494344

Citation

Ko, Jeong Suk, et al. "Quinolone Alkaloids, Diacylglycerol Acyltransferase Inhibitors From the Fruits of Evodia Rutaecarpa." Planta Medica, vol. 68, no. 12, 2002, pp. 1131-3.
Ko JS, Rho MC, Chung MY, et al. Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa. Planta Med. 2002;68(12):1131-3.
Ko, J. S., Rho, M. C., Chung, M. Y., Song, H. Y., Kang, J. S., Kim, K., Lee, H. S., & Kim, Y. K. (2002). Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa. Planta Medica, 68(12), 1131-3.
Ko JS, et al. Quinolone Alkaloids, Diacylglycerol Acyltransferase Inhibitors From the Fruits of Evodia Rutaecarpa. Planta Med. 2002;68(12):1131-3. PubMed PMID: 12494344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa. AU - Ko,Jeong Suk, AU - Rho,Mun-Chual, AU - Chung,Mi Yeon, AU - Song,Hye Young, AU - Kang,Jong Seong, AU - Kim,Koanhoi, AU - Lee,Hyun Sun, AU - Kim,Young Kook, PY - 2002/12/21/pubmed PY - 2003/3/19/medline PY - 2002/12/21/entrez SP - 1131 EP - 3 JF - Planta medica JO - Planta Med VL - 68 IS - 12 N2 - From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4 Z,7 Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6 Z,9 Z)-6,9-pentadecadienyl]-4(1 H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 microM (1), 23.8 microM (2), 20.1 microM (3) and 13.5 mu (4). SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/12494344/Quinolone_alkaloids_diacylglycerol_acyltransferase_inhibitors_from_the_fruits_of_Evodia_rutaecarpa_ DB - PRIME DP - Unbound Medicine ER -