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Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin.
Fitoterapia 2002; 73 Suppl 1:S21-9F

Abstract

Propolis, a natural product produced by the honeybee, has been used for thousands of years in folk medicine for several purposes. The extract contains amino acids, phenolic acids, phenolic acid esters, flavonoids, cinnamic acid, terpenes and caffeic acid. It possesses several biological activities such as antiinflammatory, immunostimulatory, antiviral and antibacterial. The exact mode of physiological or biochemical mechanisms responsible for the medical effects, however, is yet to be determined. In this work, we have investigated the antioxidant activity of a propolis extract deprived of caffeic acid phenethyl ester (CAPE). In addition, the activity of CAPE and galangin was also examined. Propolis extract (with and without CAPE) and its active components showed a dose-dependent free radical scavenging effect, a significant inhibition of xanthine oxidase activity, and an antilipoperoxidative capacity. Propolis extract with CAPE was more active than propolis extract without CAPE. CAPE, used alone, exhibited a strong antioxidant activity, higher than galangin. The experimental evidence, therefore, suggests that CAPE plays an important role in the antioxidant activity of propolis.

Authors+Show Affiliations

Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, V.le A. Doria 6, 95125, Catania, Italy. alrusso@mbow.unict.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12495706

Citation

Russo, A, et al. "Antioxidant Activity of Propolis: Role of Caffeic Acid Phenethyl Ester and Galangin." Fitoterapia, vol. 73 Suppl 1, 2002, pp. S21-9.
Russo A, Longo R, Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia. 2002;73 Suppl 1:S21-9.
Russo, A., Longo, R., & Vanella, A. (2002). Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia, 73 Suppl 1, pp. S21-9.
Russo A, Longo R, Vanella A. Antioxidant Activity of Propolis: Role of Caffeic Acid Phenethyl Ester and Galangin. Fitoterapia. 2002;73 Suppl 1:S21-9. PubMed PMID: 12495706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. AU - Russo,A, AU - Longo,R, AU - Vanella,A, PY - 2002/12/24/pubmed PY - 2003/1/22/medline PY - 2002/12/24/entrez SP - S21 EP - 9 JF - Fitoterapia JO - Fitoterapia VL - 73 Suppl 1 N2 - Propolis, a natural product produced by the honeybee, has been used for thousands of years in folk medicine for several purposes. The extract contains amino acids, phenolic acids, phenolic acid esters, flavonoids, cinnamic acid, terpenes and caffeic acid. It possesses several biological activities such as antiinflammatory, immunostimulatory, antiviral and antibacterial. The exact mode of physiological or biochemical mechanisms responsible for the medical effects, however, is yet to be determined. In this work, we have investigated the antioxidant activity of a propolis extract deprived of caffeic acid phenethyl ester (CAPE). In addition, the activity of CAPE and galangin was also examined. Propolis extract (with and without CAPE) and its active components showed a dose-dependent free radical scavenging effect, a significant inhibition of xanthine oxidase activity, and an antilipoperoxidative capacity. Propolis extract with CAPE was more active than propolis extract without CAPE. CAPE, used alone, exhibited a strong antioxidant activity, higher than galangin. The experimental evidence, therefore, suggests that CAPE plays an important role in the antioxidant activity of propolis. SN - 0367-326X UR - https://www.unboundmedicine.com/medline/citation/12495706/Antioxidant_activity_of_propolis:_role_of_caffeic_acid_phenethyl_ester_and_galangin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367326X02001879 DB - PRIME DP - Unbound Medicine ER -