Tags

Type your tag names separated by a space and hit enter

Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones.
Cancer Epidemiol Biomarkers Prev. 2002 Dec; 11(12):1689-96.CE

Abstract

Epidemiological evidence suggests a geographical basis for the incidence of prostate cancer and dietary factors, including isoflavone consumption, may be linked to this phenomenon. This paper reports a nonrandomized, nonblinded trial with historically matched controls from archival tissue designed to determine the effects of acute exposure to a dietary supplement of isoflavones in men with clinically significant prostate cancer before radical prostatectomy. Thirty-eight patients were recruited to the study upon diagnosis of prostate cancer. Before surgery, 20 men consumed 160 mg/day of red clover-derived dietary isoflavones, containing a mixture of genistein, daidzein, formononetin, and biochanin A. Serum PSA, testosterone, and biochemical factors were measured, and clinical and pathological parameters were recorded. The incidence of apoptosis in prostate tumor cells from radical prostatectomy specimens was compared between 18 treated and 18 untreated control tissues. There were no significant differences between pre- and posttreatment serum PSA, Gleason score, serum testosterone, or biochemical factors in the treated patients (P > 0.05). Apoptosis in radical prostatectomy specimens from treated patients was significantly higher than in control subjects (P = 0.0018), specifically in regions of low to moderate-grade cancer (Gleason grade 1-3). No adverse events related to the treatment were reported. This report suggests that dietary isoflavones may halt the progression of prostate cancer by inducing apoptosis in low to moderate-grade tumors, potentially contributing to the lower incidence of clinically significant disease in Asian men. The assessment of new prostatic therapies aimed at increasing apoptosis should control for intake of dietary isoflavones.

Authors+Show Affiliations

Centre for Urological Research, Monash Institute of Reproduction & Development, Monash University, Victoria 3168, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12496063

Citation

Jarred, Renea A., et al. "Induction of Apoptosis in Low to Moderate-grade Human Prostate Carcinoma By Red Clover-derived Dietary Isoflavones." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 11, no. 12, 2002, pp. 1689-96.
Jarred RA, Keikha M, Dowling C, et al. Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. Cancer Epidemiol Biomarkers Prev. 2002;11(12):1689-96.
Jarred, R. A., Keikha, M., Dowling, C., McPherson, S. J., Clare, A. M., Husband, A. J., Pedersen, J. S., Frydenberg, M., & Risbridger, G. P. (2002). Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 11(12), 1689-96.
Jarred RA, et al. Induction of Apoptosis in Low to Moderate-grade Human Prostate Carcinoma By Red Clover-derived Dietary Isoflavones. Cancer Epidemiol Biomarkers Prev. 2002;11(12):1689-96. PubMed PMID: 12496063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. AU - Jarred,Renea A, AU - Keikha,Mohammad, AU - Dowling,Caroline, AU - McPherson,Stephen J, AU - Clare,Anne M, AU - Husband,Alan J, AU - Pedersen,John S, AU - Frydenberg,Mark, AU - Risbridger,Gail P, PY - 2002/12/24/pubmed PY - 2003/4/5/medline PY - 2002/12/24/entrez SP - 1689 EP - 96 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 11 IS - 12 N2 - Epidemiological evidence suggests a geographical basis for the incidence of prostate cancer and dietary factors, including isoflavone consumption, may be linked to this phenomenon. This paper reports a nonrandomized, nonblinded trial with historically matched controls from archival tissue designed to determine the effects of acute exposure to a dietary supplement of isoflavones in men with clinically significant prostate cancer before radical prostatectomy. Thirty-eight patients were recruited to the study upon diagnosis of prostate cancer. Before surgery, 20 men consumed 160 mg/day of red clover-derived dietary isoflavones, containing a mixture of genistein, daidzein, formononetin, and biochanin A. Serum PSA, testosterone, and biochemical factors were measured, and clinical and pathological parameters were recorded. The incidence of apoptosis in prostate tumor cells from radical prostatectomy specimens was compared between 18 treated and 18 untreated control tissues. There were no significant differences between pre- and posttreatment serum PSA, Gleason score, serum testosterone, or biochemical factors in the treated patients (P > 0.05). Apoptosis in radical prostatectomy specimens from treated patients was significantly higher than in control subjects (P = 0.0018), specifically in regions of low to moderate-grade cancer (Gleason grade 1-3). No adverse events related to the treatment were reported. This report suggests that dietary isoflavones may halt the progression of prostate cancer by inducing apoptosis in low to moderate-grade tumors, potentially contributing to the lower incidence of clinically significant disease in Asian men. The assessment of new prostatic therapies aimed at increasing apoptosis should control for intake of dietary isoflavones. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12496063/Induction_of_apoptosis_in_low_to_moderate_grade_human_prostate_carcinoma_by_red_clover_derived_dietary_isoflavones_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12496063 DB - PRIME DP - Unbound Medicine ER -